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Biomedical subjects

R J Hancock

Publications and source records attributed to R J Hancock.

27 records · Page 2Linked to original sources
PubMed1979

Complement fixing activities of normal mammalian sera for homologous and heterologous sperm.

The species of the natural anti-sperm antibodies found in normal mammals have been assessed using complement fixation tests. Heated rabbit sera showed complement fixing activity with both rabbit and guinea pig sperm, indicating that rabbit natural anti-sperm antibodies do not show clear cut species specificity in these interactions. On average, rabbit sera reacted more strongly with rabbit sperm that with guinea pig sperm but the difference fell short of statistical significance (P < 0.05) and there was considerable variation between sera in their anti-sperm activities. There were, however, clear species differences between rabbit and guinea pig sera in that heated guinea pig sera showed significantly weaker anti-sperm activity than heated rabbit sera (P < 0.005). Mouse vas sperm showed greater complement fixing activities (in combination with mouse serum) than did epididymal sperm (P = 0.05). These results are discussed in relation to possible functions of natural anti-sperm antibodies.

Animals↗
PubMed1979

Spermotoxic properties of IgG fractions from normal rabbit sera.

The antisperm activities of IgG fractions prepared from normal rabbit sera by three different techniques (ammonium sulphate precipitation, gel filtration, and DEAE-Sephadex absorption) were tested using a cytotoxic assay, and antisperm activity detected in fractions prepared by each of these techniques. The nature of the interactions between sperm and IgG molecules from normal sera, and possible functions of "natural" antisperm antibodies, are discussed.

Animals↗
PubMedDate not supplied

The RCP stroke audit package in practice.

This paper describes the use of the Royal College of Physicians 'stroke audit package' in an audit of the care of 156 patients. Recording of history and management compared favourably with that recorded on the RCP database. For a number of items, recording was significantly improved when a locally developed 'checklist', based on the RCP standards, was utilised by trainee medical staff. Benefits of the audit package, and proposed changes in practice, are briefly outlined.

Cerebrovascular Disorders↗