PubMed Health⌕ Search

Biomedical subjects

R J Harp

Publications and source records attributed to R J Harp.

12 recordsLinked to original sources
PubMed1991

Absence of drug effects on rabbit blood-aqueous barrier permeability to non-electrolytes.

The effects of either topical epinephrine, norepinephrine or pilocarpine upon the entry of non-transported radioactive solutes into the anterior or posterior chamber of pigmented rabbit eyes was examined after intravenous solute perfusion. Solutes employed were urea, thiourea, sucrose and inulin. They were infused at a rate that maintained constant plasma levels from 1 minute through 5 hours of intravenous perfusion. Anterior and posterior chamber samples were taken at either 5 minutes or 5 hours after infusion of solutes, but in either case at 1 hour after drug administration. Differences between the 5 minute and 5 hour data showed more solute entry with the passage of time, and differences were found between the rate of solute entry at both times based upon molecular size. However, while occasional statistically significant differences were found between certain drug treatments, no drug effects were noted on solute entry into the treated eye either when compared to the contralateral untreated eye or to a separate untreated control group.

Animals↗
PubMed1990

Prevalence of dystonia in veterans on chronic antipsychotic therapy.

The prevalence of dystonia was studied in 125 veterans on chronic antipsychotic therapy using a detailed and systematic examination. Twenty-seven out of 125 had dystonic manifestations. The most common areas involved were hands and jaw. There was no relation between the presence or absence of dystonia, and duration of neuroleptic therapy. There was a tendency for tardive akathisia to occur more frequently in patients with dystonia than in those without it (Fisher's exact probability test, p = 0.0656). Tardive dystonia in its milder forms may be more common than currently believed.

Adult↗
PubMed1990

Acute renal failure in sickle cell anemia.

We performed a case-control study of acute renal failure (ARF) in patients hospitalized with sickle cell anemia (SCA). Twelve of the 116 patients (10.3%) whose records were suitable for analysis were diagnosed as having ARF based on a minimum of doubling of their serum creatinine levels (mean rise was 205 +/- 49%). ARF patients were more likely to have been admitted with infection and had a lower mean hemoglobin level than the control group. Volume depletion was the most common identifiable cause for ARF. Two of 3 patients with severe ARF received dialytic support. Ten of 12 ARF patients survived and subsequently had recovery of renal function.

Acute Kidney Injury↗
PubMed1985

Radioimmunoassay of progesterone in saliva: a simplified technique using 125I-radioligand.

The value of serial salivary progesterone (P) determinations for evaluation of corpus luteum function compared with sporadic serum samplings is recognized. Salivary P concentrations have previously been determined by a relatively difficult assay which utilizes a tritiated radioligand. The present study was designed to compare this conventional method with a simpler assay utilizing an iodinated radioligand. The values obtained with two different radioimmunoassay (RIA) systems were compared for samples collected throughout the luteal phase of seven normal menstrual cycles and three conception cycles. In the seven nonconception luteal phases as well as in the three conception luteal phases, daily salivary P determinations by the two techniques correlated significantly with each other (r = 0.56; P less than 0.001). For the seven nonconception luteal phases, the salivary P determinations obtained by 125I RIA (Saliva 125I) correlated significantly with the matched serum values (r = 0.54; P less than 0.001). However, the correlation was poor between the salivary P determinations obtained by the 3H RIA (Saliva 3H) and the matched serum values. The simplicity and accuracy of the 125I RIA and the convenience of saliva sampling provide a practical approach to monitor human luteal function.

Adult↗
PubMed1984

Racial variations in electrocardiograms and vectorcardiograms between black and white children and their genesis.

Despite a general clinical impression that the ECG of black children differs from that of white children, none of the normal standards in children have taken race into consideration. Biographic data, blood pressure, hemoglobin, ECG, Frank VCG and echocardiogram were obtained in 244 normal children (124 blacks and 120 whites) aged 3-17 years and 144 measured parameters and 57 computed variables were analyzed. The children were divided into age groups of 3-5, 6-10, 11-14, and 15-17 years. The 15-17 year age group was small and therefore excluded. In the 3-5-year age group there were no sex differences (p greater than 0.05) nor were there any differences (p greater than 0.05) observed between black and white children. No significant sex differences were seen in 6-10-year-olds. However, the amplitude of the R wave in lead I, S in V1 and V4, and the sums of SV1 and RV6 as well as SV1 and RV5 on the ECG, and X to the left and Y to the inferior on VCG were greater in black than in white children (p less than 0.01). In 11-14-year-olds many sex-related differences were seen in each race. R in leads I, II, AVL, AVF and V4, S wave in V1 and V4R, and the sums of SV1 and RV5 as well as SV1 and RV6 in the ECG, and Y inferior and Z anterior in the VCG were higher (p less than 0.01) in black males than white males. However, no differences (p greater than 0.05) were observed between black and white 11-14-year-old girls. To understand the causes of these differences, comparisons of the biographic data, blood pressure, hemoglobins and echocardiograms were made. The height, weight, body surface area, chest circumference, AP diameter of the chest, and diastolic and systolic blood pressure were similar (p greater than 0.1) in all groups. The hemoglobin level was lower in black than white children (p less than 0.05). However, this difference was seen in all age-sex subgroups, suggesting that hemoglobin level was not responsible for the ECG-VCG differences. The LV posterior wall in diastole was thicker and the anterior chest wall to mid-LV distance was shorter in black than in white children in age-sex subgroups in which ECG-VCG differences were observed.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
PubMed1979

Acid-base determinations in amniotic fluid and blood of normal late pregnancy.

Amniotic fluid (AF) and arterial blood were obtained almost simultaneously from 59 healthy third-trimester pregnant women. Oxygen and carbon dioxide tensions (Po2, Pco2), pH, bicarbonate (Bicarb), total carbon dioxide (TCO2), lactate (L), and pyruvate (P) concentrations were measured. Only AF-Bicarb, AF-TCO2, AF-pH, and AF-P showed a statistically significant correlation, negative, with gestational age. AF-Po2, AF-pH, AF-Bicarb, and AF-TCO2, were lower, and AF-Pco2 was higher than in maternal blood. Amniotic fluid lactate was about 6 times, and AF-P was 2 times higher than maternal blood levels. The latter, the low bicarbonate, and the high Pco2 all contributed to the acidic pH of AF. Amniotic fluid pH was affected by fetal and maternal variables, notably maternal pH. There was no correlation between AF-Po2 and Pao2 (arterial oxygen tension), between AF-Pco2 and Paco2 (arterial carbon dioxide tension), or between AF-L and blood L. AF-Po2, AF-Pco2, and AF-L may correlate better with the intrauterine fetal status than AF-pH. Normal values obtained in this study should be useful as a baseline to monitor changes in the intrauterine environment in abnormal prgenancies.

Acid-Base Equilibrium↗
PubMed1979

Glycosylated hemoglobins in normal pregnancy and gestational diabetes mellitus.

Glycosylated hemoglobins (HbA1) were measured in 23 nonpregnant women, 53 normal pregnant women, and 22 Class A diabetics; the results were 6.1 +/- 0.7%, 5.8 +/- 1.0%, and 7.0 +/- 1.3% in the 3 groups, respectively. The decrease in normal pregnancy was insignificant, whereas the increase in HbA1 in Class A diabetics over the other 2 groups was statistically significant (P less than 0.05). HbA1 did not correlate with maternal age, gravidity, or gestational age at the time of sampling. There was no difference in HbA1 between whites and blacks [patients with sickle hemoglobin (HbS) were excluded] (P = 0.35), nor between primigravidas and multigravidas (P = 0.8). HbA1 levels did not correlate with the birth weight ratios in either normal pregnancies (r = 0.06, P = 0.7) or in Class A diabetics (r = -0.4, P = 0.09). This is probably due to the long interval between HbA1 determination and delivery (9.9 weeks).

Adult↗
PubMed1975

Twelve-year experience with mitral valve replacement.

Between 1962 and 1974, 203 mitral prostheses were implanted in 201 patients. Of the 102 survivors, 29 have Beall, 25 Kay-Shiley, 22 Starr-Edwards (SE) 6000, and 27 SE 6320 valves. Full rehabilitation was achieved in 25 patients with Beall and 23 with SE 6320 valves. Sixteen with SE 6000 valves remain normally active. Only 8 with Kay-Shiley prostheses have resumed normal activities. Systemic embolization occurred with the following frequencies per 1,000 patient-months: 13.7 for those receiving the Kay-Shiley valve; 7.2 in the SE 6000 group; 4.3 after SE 6320 implantations; and 3;1 for the Beall group. Other prosthesis-related complications that were much less frequent included detachment (10), bacterial endocarditis (5), and hemolysis (10). Three Kay-Shiley valves malfunctioned. Life table analyses reveal the following survival rates: 33% after 11 years in the SE 6000 patients, 50% after 7.5 years in the Kay-Shiley group, 69% 2.5 years after SE 6320 implantation, and 65% 3.5 years after replacement with a Beall valve. Evidence is presented to support the extension of operative treatment to patients with less advanced valvular heart disease. Postoperative anticoagulation remains an unresolved issue despite lower rates of thromboembolism. More cumulative analyses of survival and morbidity and follow-up hemodynamic data are needed to assess the Beall and SE 6320 prostheses now employed in our valve replacement program.

Adolescent↗