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Biomedical subjects

R J Holt

Publications and source records attributed to R J Holt.

79 records · Page 5Linked to original sources
PubMedDate not supplied

Hyperglycemia associated with propranolol and chlorpropamide coadministration.

A 59-year-old patient with acute pancreatitis is described, whose treatment was complicated by concomitant diabetes mellitus and arterial hypertension. He received propranolol and insulin without subsequent problems; however, when the insulin was changed to chlorpropamide, a significant increase in blood sugar occurred. It was postulated that this increase in blood sugar was due to an antagonistic action of propranolol at the pancreatic level which interfered with the action of chlorpropamide.

Acute Disease↗
PubMedDate not supplied

Uncharacteristic cutaneous reactions induced by quinidine.

Two patients who presented with unusual cutaneous reactions attributed to quinidine are described. One had a diffuse nonpruritic macular rash, and the other had a localized pruritus without cutaneous manifestations. Both resolved upon dechallenge with quinidine. Disopyramide phosphate was substituted for quinidine in both cases, without subsequent problems.

Drug Eruptions↗