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R J Joehl

Publications and source records attributed to R J Joehl.

62 records · Page 4Linked to original sources
PubMed1984

Symptomatic malignant melanoma of the gastrointestinal tract. Operative treatment and survival.

Malignant melanoma involving the gastrointestinal tract is a common autopsy finding in patients who die with this disease. Melanoma metastatic to bowel infrequently causes symptoms. Some investigators suggest that survival following the onset of gastrointestinal symptoms is very poor and, as a result, surgical intervention to relieve symptoms should be avoided. We reviewed the clinical courses of 15 consecutive patients with symptomatic malignant melanoma of the bowel who underwent resection alone or in combination with bypass of symptomatic intestinal lesions. There were no deaths within 30 days of operation; 14 patients obtained relief of intestinal symptoms; 11 patients survived a mean of 7.9 months; and four patients are alive 2, 7, 22, and 23 months after operation. These results suggest that operations to treat symptomatic intestinal melanoma provide reasonable palliation and survival for patients with this disease.

Adult↗
PubMed1983

Moxalactam. Evaluation of clinical bleeding in patients with abdominal infection.

Previous clinical studies have emphasized that hypoprothrombinemia may occur during treatment with moxalactam disodium, a new broad-spectrum cephalosporin. Usually, this abnormality is corrected by administering vitamin K. Recent case reports have described bleeding complications associated with moxalactam therapy and suggested that platelet function is depressed by this drug. We studied eight patients with abdominal infection who were treated with moxalactam. Six of them had prolonged template bleeding times, and two had clinically significant hemorrhage (epistaxis, hematuria, and rectal bleeding) during treatment with moxalactam. These observations suggest that coagulation studies and template bleeding times should be monitored during moxalactam therapy, especially before major surgery.

Abdomen↗
PubMed1983

Experimental cancer of the bowel in the Nb rat.

An animal model of bowel cancer, induced by 1,2-dimethyl hydrazine, has been developed in the Nb rat. Invasive polypoid carcinomas of the colon were noted in nine rats surviving 29 weeks after the carcinogen was first administered. Two of these nine rats also developed duodenal carcinomas. Because dosage schedules are known from previous experiments with the Nb rat, this animal model may be useful for evaluating the effects of cytotoxic drugs on experimental bowel cancer.

1,2-Dimethylhydrazine↗
PubMed1983

Norepinephrine stimulates amylase release from pancreatic acini.

alpha-Adrenergic blockade decreases food-stimulated amylase secretion in dogs, suggesting that physiologic sympathetic nerve discharge of norepinephrine enhances pancreatic enzyme secretion. Previous studies have not separated direct effects of adrenergic agonists on pancreatic exocrine cells from effects on blood flow. An in vitro preparation of dispersed acini from guinea pig pancreas was modified and amylase release in response to common pancreatic stimulants was measured. It was demonstrated that physiologic concentrations of norepinephrine enhance amylase release from dispersed pancreatic acini evoked by supramaximal concentrations of cholecystokinin. These observations suggest that the sympathetic nervous system plays a role in modulating pancreatic enzyme secretion independent of effects on blood flow.

Amylases↗
PubMed1979

Hemangioma of the temporalis muscle: a case report and review of the literature.

Hemangiomas are the most common benign tumors of infancy and childhood. Most involve skin and subcutaneous tissues and are readily visible. Intramuscular hemangiomas are very uncommon, and rarely appear in the musculature of the head and neck. A 59-year-old woman who had had a lipoma excised from her left temporal region many years earlier underwent excision of a hemangioma of the left temporalis muscle. Intramuscular hemangiomas do not spontaneously involute and should be removed as soon as they are diagnosed, in order to obviate later destruction of the involved muscle and adjacent tissues. Preoperative embolization of the hemangioma may reduce intraoperative hemorrhaging.

Eyeglasses↗