Biomedical subjects

R J Kau

Publications and source records attributed to R J Kau.

6 recordsLinked to original sources

PubMed1990

[Drainage of the middle ear].

Otitis media with effusion occurs very frequently in childhood and usually heals without therapy. The condition is thought to be due to a higher susceptibility to infections of the upper respiratory tract and the fact that the Eustachian tube is not yet functioning perfectly at that age. Many authors explain this astonishingly high rate of spontaneous recoveries by tube malfunction alone, never even considering a middle ear clearance system. It is known from the paranasal sinuses that the cavities are regularly and continually cleaned according to very precise rules. In in-vivo experiments with guinea pigs the author proved that there is an obvious similarity between the paranasal sinus and the middle ear as far as the clearance system is concerned. By applying tracer substances to the middle ear mucosa the usual drainage pathways out of the middle ear into the Eustachian tube, and the different rates of drainage were very precisely defined.

Animals↗

PubMed1990

[Otitis media].

Explore the source record for details and available documents.

Brain Abscess↗

PubMed1989

[Initial results of immunotherapy approaches to tumor treatment in the animal model].

The possibilities of using immunocytes in cancer therapy have been increasing during the last few years. Contrary to the promising results gained by in vitro experiments, several clinical trials have shown that, on the one hand, it is difficult to preserve a quantity of cells big enough to inhibit tumours, and they have also shown that, on the other hand, antitumour lymphocytes do not get into the tumour. That is why we concentrated on improving the tumour selectivity of the antitumour lymphocytes. We carried this out practising two sets of experiments. First we incubated patient lymphocytes with tumour extract and vaccinated them in this manner. Secondly, by binding antitumour antibodies to lymphocytes, we could improve the ability of lymphocytes to bind with tumour cells. We tested these therapy models on human tumours and on tumour cell lines. Both were implanted in the renal capsule space of nude mice.

Adenocarcinoma↗

PubMed1987

[Latency of the acoustic evoked stapedius reflex and its clinical significance].

We measured the mean latency of the stapedius reflex by normal listeners. We observed a prolongation of the latency by patients with operative and histological confirmed neurinoma of the VIII. nerve. Even if the measured stapedius reflex latency considerably varies, this method represents, any way, an important support to BERA to discover tumours of the cerebello-pontine angle.

Adolescent↗

PubMed1987

[Sedation in ambulatory BERA (brainstem electric response audiometry) studies in childhood].

We use BERA to determine the hearing threshold of children. This examination is most of the time performed on outpatients and often combined with a minor surgery. That's the reason why a sedation has to fulfill following conditions: 1. a quick, non-traumatic induction of anaesthesia--normally--without premedication; 2. an anesthesia deep enough to enable us to carry out a minor surgery as well as to get the best reliable BERA results; 3. a short period of wake-up as the patient should leave the hospital as soon as possible. In short, we got the best results first using Halothane as inhalant for the minor surgery and continuing with Midazolam as i.v. sedative for BERA examination.

Anesthesia, General↗

PubMed1986

[Thorotrastoma--late damage following thorotrast arteriography].

We report two cases of cervical thorotrastoma. Thorotrast is no longer used as a radiographic contrast agent, so that the rare thorotrastoma is often forgotten in the differential diagnosis of hypopharyngeal tumours. Surgical treatment of a thorotrastoma is not recommenced.

Aged↗