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Biomedical subjects

R J Manning

Publications and source records attributed to R J Manning.

12 recordsLinked to original sources
PubMed1995

Estrogen/progesterone treatment of diffuse antral vascular ectasia.

A case of acute and chronic gastrointestinal bleeding secondary to antral vascular ectasia is presented. The pattern of antral vascular ectasia was the diffuse form. After attempted treatment with endoscopic laser photocoagulation proved ineffective, the bleeding was treated with an estrogen/progesterone combination. The bleeding ceased with this medical therapy. The lesion of antral vascular ectasia persisted, however, despite the cessation of bleeding. Attempted maintenance therapy, consisting of reduction in frequency of estrogen/progesterone therapy to every third day, resulted in resumption of bleeding, requiring reinstitution of daily therapy for control.

Aged↗
PubMed1990

Constant vs variable resistance knee extension training.

To compare the effect of constant resistance (CR) and variable resistance (VR) training on full range-of-motion (ROM) strength development, 22 men and 27 women (age = 26 +/- 5 yr) were randomly assigned to either a CR training group (N = 17), a VR training group (N = 17), or a control group (N = 15) that did not train. The CR and VR groups trained 2 to 3 d.wk-1 for 10 wk. Subjects completed one set of full ROM (120 to 0 degrees of flexion) bilateral knee extensions with an amount of weight that allowed 8 to 12 repetitions during each training session. For the VR group, resistance was varied with a cam supplied by the manufacturer (Nautilus). For the CR group, the cam was removed and replaced with a round sprocket. Prior to and after training, maximal voluntary isometric torque was measured at 9, 20, 35, 50, 65, 80, 95, and 110 degrees of knee flexion. Analysis of covariance indicated that the VR and CR groups gained strength at all angles (P less than or equal to 0.05) when compared to the control. [table: see text] There was no difference (P greater than 0.05) between the CR and VR groups at any angle, and the magnitude of strength gained was similar (P greater than 0.05) among angles for both groups. These data indicate that both CR and VR knee extension training elicit full ROM strength development.

Adult↗
PubMed1987

Hodgkin's disease presenting as diffuse nonspecific inflammation of small bowel.

I report an unusual case of primary retroperitoneal Hodgkin's disease. The initial presentation radiographically involved diffuse thickening of small bowel folds from the duodenum through the terminal ileum. The histologic picture consisted of diffuse, nonspecific inflammation with an infiltrate resembling that seen in tropical sprue. The clinical picture consisted of progressive diffuse abdominal pain, fever, diarrhea, and weight loss. The histologic and radiographic abnormalities returned to normal with chemotherapy. Computerized search of the English language literature uncovered no similar case presentation.

Adult↗
PubMed1984

Studies on the origins of biliary immunoglobulins in rats.

This study was designed to investigate the origins of biliary immunoglobulins in rats. Natural antibodies to species of Lactobacillus and Staphylococcus were detected in blood, bile, and lymph, with predominant activity being associated with immunoglobulin A in lymph and bile and with immunoglobulins M and G in blood. Six hours after thoracic duct cannulation, serum immunoglobulins G, M, and A had fallen to 60%, 65%, and 40%, respectively, of the preoperative levels, whereas the level of total and specific immunoglobulin A in bile was reduced to 25% with no significant decline of immunoglobulin G. Thoracic duct occlusion caused a similar selective reduction in biliary immunoglobulin A. It is calculated that 50% of thoracic duct lymph immunoglobulin A entering the blood is secreted in bile. Synthesis of immunoglobulins M, G, and A in the liver was established by the detection of antibody-secreting cells. It is proposed that the major part of biliary immunoglobulin A is derived from intestinal lymphoid tissues and that a portion of the remainder, as well as part of biliary immunoglobulins M and G, results from local synthesis.

Animals↗
PubMed1978

Watery diarrhea syndrome with elevated levels of vasoactive intestinal polypeptide associated with pancreatitis and pancreatic pseudocyst.

A 32-year old patient presented with recurrent pancreatitis, severe watery diarrhea and elevated serum levels of vasoactive intestinal polypeptide. His diarrhea appeared to respond to intramuscular propantheline. Initially he improved but had another attack of pancreatitis while hospitalized. Evaluation by ultrasound revealed the presence of a pseudocyst and endoscopic retrograde pancreatography demonstrated complete occlusion of the main pancreatic duct. Exploratory laparotomy was performed with drainage of a pseudocyst. Analysis of the pseudocyst fluid revealed an elevated amylase, lipase and vasoactive intestinal polypeptide level. It is believed that this patient's severe diarrhea was related to his pancreatitis and pancreatic pseudocyst with elevated levels of vasoactive intestinal polypeptide.

Adult↗
PubMed1976

Chronic delta-9-tetrahydrocannabinol. Transient and lasting effects on avoidance behavior.

Delta-9-Tetrahydrocannabinol (THC) was administered to albino rats with extensive experience in free-operant (Sidman) lever-press shock avoidance. Dosing (30 mg/kg intragastrically) continued once daily, 3 hr before testing, for 1 to 6 weeks. Significant changes were noted in the response rates of several animals, but both the magnitude and direction of these were highly variable. However, shock rates were reliably elevated by THC, but complete tolerance was observed within 6 sessions. In several rats this was followed by sessions with significantly lower shock rates than the predrug baseline. These rats continued to perform at this level of proficiency until THC was discontinued, at which point the baseline was reacquired. These data emphasize that an important determinant of tolerance to a drug effect is the consequence of the effect for the organism.

Animals↗