Biomedical subjects

R J Pugh

Publications and source records attributed to R J Pugh.

13 recordsLinked to original sources

PubMed1989

Scanning electron microscopic evaluation of endosonic and hand instrumentation in the debridement of root canal systems.

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Dental Pulp Cavity↗

PubMed1979

Fatal bleeding from gastric ulceration during first day of life--possible association with social stress.

Death from haemorrhage is described in a 21-hour-old baby boy with acute gastric ulceration. Particular note is made of the very high level of psychosocial maternal stress during the last trimester of pregnancy. A causal relationship of this stress and the peptic ulceration is suggested, with gastrin as the mediator.

Acute Disease↗

PubMed1978

The battered fetus.

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Congenital Abnormalities↗

PubMed1978

Pyridoxol metabolism in vitamin B6-responsive convulsions of early infancy.

As there is uncertainty about the nature of the metabolic defect in vitamin B6-responsive convulsion, certain aspects of pyridoxol metabolism were studied in 3 patients who were believed on clinical grounds to have the condition. The findings were compared with those in healthy children and adults, and in children with mental handicap. The magnitude of the initial rise and the subsequent fall in plasma pyridoxal phosphate (PALP) concentrations after a load of pyridoxol suggested that the vitamin B6-responsive patients were able to synthesise PALP normally but were unable to maintain the prolonged high levels normally found in plasma. The urinary excretion of 4-pyridoxic acid was within normal limits, but the excretion of pyridoxol after the load was raised. It is suggested that there may be an instability of the PALP-albumin complex in this condition. Some of the biochemical features were also observed in an infant presenting with convulsions soon after birth but without evidence of clinical B6-dependency.

Adult↗

PubMed1977

Poliomyelitis-like illness after acute asthma.

Two children had pain in one arm, followed by weakness and wasting, after an acute exacerbation of bronchial asthma. Similar cases in which a poliomyelitis-like illness was associated with acute asthma have been reported, but the relationship between the two remains conjectural.

Arm↗

PubMed1976