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R J Robijn

Publications and source records attributed to R J Robijn.

6 recordsLinked to original sources
PubMed1995

Flexible endoscopic treatment of Zenker's diverticulum: a new approach.

BACKGROUND AND STUDY AIMS: In the past, a number of treatment modalities have been used for the management of a Zenker's diverticulum. These include transcervical diverticulectomy, myotomy, or laser or diathermy treatment via rigid endoscopes. Up to the present, no reports of the treatment of a Zenker's diverticulum with a flexible endoscope have been published. PATIENTS AND METHODS: In this study, we present the results of our first 20 patients (13 male; mean age 82 years) prospectively treated with a flexible endoscope applied through diathermy. All patients had significant symptoms such as dysphagia, recurrent aspiration pneumonia and/or weight loss. RESULTS: Treatment using a mean of three sessions per patient was successful, with a good symptomatic response in all subjects. There were no severe complications associated with the therapy. Four patients complained about a sore throat for a few days. During follow-up (mean 6-7 months), three patients died due to unrelated causes, and 17 remained asymptomatic. CONCLUSIONS: An important advantage is that it is possible to perform the treatment without general anesthesia, and therefore also in patients whose general health is poor. The technique can easily be performed in an interventional endoscopy unit. Our first experiences show that flexible endoscopic treatment is an effective and relatively safe method.

Aged↗
PubMed1995

Intestinal T lymphocytes.

The intestine is largely colonized by bacteria and further exposed to an immense array of ingested and shed immunogenic material. Therefore, the gut associated lymphoid tissue plays a major role in the human immune system. It may even constitute a unique immune system of its own, since it has been demonstrated to differ anatomically, phenotypically, functionally and on a molecular basis from its systemic counterpart and other peripheral lymphoid tissue. This is ultimately reflected by the observation in (transgenic) mice that intraepithelial T cells can develop independently of the thymus. Along the same lines, a rapidly growing body of evidences suggests that human bone marrow precursors can home to the gut epithelium, rearrange their T cell receptor genes and further differentiate in the mucosal micro environment. This, and other features that characterize the 'diffuse' mucosal T cell infiltrate will be discussed.

Animals↗
PubMed1993

Phenotypic and molecular characterization of human monoclonal TCR gamma/delta T-cell lines from jejunum and colon of healthy individuals.

We have performed a phenotypic and molecular analysis of monoclonal TCR gamma/delta T-cell lines derived from jejunal and colonic biopsies of healthy individuals. Flow cytometric analysis employing a panel of 24 monoclonal antibodies (MoAbs) demonstrated that intestinal TCR gamma/delta intraepithelial lymphocytes (IEL) constitute a phenotypically heterogeneous population. Nucleotide sequence analysis of expressed TCR delta variable (V) regions revealed the dominant utilization of the V delta 2 and D delta 3 gene segments and frequent rearrangement of J delta 3. IEL V delta regions displayed extensive junctional diversity as a result of N and P insertion and the utilization of D delta 3 in all three reading frames. The results demonstrate that intestinal TCR gamma/delta T cells from healthy individuals constitute a phenotypically heterogeneous population expressing V delta regions that differ from their systemic counterparts.

Amino Acid Sequence↗