Contact urticaria from winged bean the (Psophocarpus tetragonolobus).
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Biomedical subjects
Publications and source records attributed to R J Rycroft.
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Organic di-isocyanates are used widely in industry. The concomitant respiratory complications are well-known. Cutaneous problems precipitated by skin contact with these chemicals are less well recognised. Allergic contact dermatitis caused by exposure to di-cyclohexylmethane 4,4'-di-isocyanate has been demonstrated in a factory where it was used to form a surface-coating polyurethane. Attention to hygiene methods may have reduced the incidence of cases.
Allergic contact sensitivity to 5-[(2-aminoethyl)thiomethyl]-N, N-dimethyl-2-furanmethanamine, a diamino intermediate in the synthesis of a novel H2 antagonist, Ranitidine is reported in an industrial chemist with hand dermatitis, who had been working for a prolonged period on the conversion of this intermediate to its fumarate salt.
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Patch testing of 40 patients with chronic inflammatory ear disease demonstrated medicament allergic contact dermatitis in 35%. The most frequent sensitizers were neomycin, framycetin, clioquinol and gentamicin. Although allergic contact dermatitis to dewaxing ear drops was unusual, irritant reactions were common.
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Two independent cases of suspected occupational allergic contact dermatitis from tobacco are reported to illustrate the difficulties inherent in the accurate diagnosis of this condition. An investigatory procedure is outlined whereby the comparatively rare cases of genuine contact sensitivity to tobacco can be distinguished from other commoner dermatoses.
A case is reported of allergic contact dermatitis from 4-bromoacetoacet-2,4-dimethylanilide and 4-bromomethyl-6,8-dimethyl-2(1H)-quinolone in a 19-year-old chemical laboratory technician. The relationship between the chemical reactivity of these compounds and their sensitizing potential is discussed.