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Biomedical subjects

R J Siemelink

Publications and source records attributed to R J Siemelink.

3 recordsLinked to original sources

Is antibiotic treatment of chronic sinusitis effective in children?

A double-blind randomized controlled trial on 79 patients aged between 2 and 12 years with chronic sinusitis showed no significant advantage of adding antibiotics to the treatment by sinus lavage. The prognosis after both 6 and 12 weeks was worse for patients with bilateral opaque sinus radiographs. Half of the Branhanmella catarrhalis cultured in this study were beta-lactamase producing organisms, therefore antibiotics prescribed for this group of children should be chosen bearing this in mind.

Cefaclor↗

Auditory brainstem responses in the normal beagle.

The latencies of the peaks in brainstem responses and the threshold response were determined in 18 healthy beagles. In the first series of measurements the dogs were sedated and the stimulus was delivered via an in-the-ear transducer. The latencies, the threshold levels, and the influence of the stimulus repetition rate on the latencies were measured. Using a miniature electric microphone in the outer ear canal near the tympanic membrane, it was found that at a level setting corresponding to 0 dB human level (HL) the major peak in damped oscillation during condensation reached a sound pressure level (SPL) of about 27 dB and the secondary rarefaction peak reached 24 dB SPL. In the second series of measurements the dogs were not sedated and the stimulus was delivered via a headphone. The wave forms, the mean latencies for peaks I to V as a function of the stimulus level, and the threshold of each wave are presented from both series. In the first series the latency values at 80 dB HL (107 dB SPL) were 1.21, 1.97, 2.67, 3.12 and 3.61 ms for peaks I, II, III, IV and V, respectively. The thresholds for peaks I to V were 47.5 +/- 9.5, 47.5 +/- 11.5, 41.3 +/- 13.0, 63.3 +/- 17.4 and 28.0 +/- 9.7 dB HL, respectively. The difference in peak latency between the first and the second series was 0.065 ms. This difference corresponded to the difference in length of the acoustic pathways.(ABSTRACT TRUNCATED AT 250 WORDS)

Analysis of Variance↗

Comparison of spiramycin and doxycycline in the empirical treatment of acute sinusitis: preliminary results.

In an open randomized comparative study, the clinical and bacteriological efficacy and safety of spiramycin were compared with those of doxycycline in patients with acute sinusitis. Spiramycin was given at a dose of 1 g bd for 10 days and doxycycline at 200 mg once a day on day 1 and 100 mg once a day from day 2 to day 10. Clinical and bacteriological evaluations of efficacy were carried out at the end of therapy. In case of clinical cure, a last follow-up visit was made 15 days after the end of therapy. Adverse effects were recorded. To date 12 assessable patients have been treated with spiramycin and 15 with doxycycline. In the spiramycin group, nine patients were clinically cured at the end of therapy (with no relapse at the last follow-up visit). In the doxycycline group, nine patients were clinically cured at the end of therapy (with no relapse at the last follow-up visit). The data so far available from this study suggest that spiramycin presents an alternative to doxycycline in the treatment of acute sinusitis.

Acute Disease↗