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Biomedical subjects

R J Strobos

Publications and source records attributed to R J Strobos.

15 recordsLinked to original sources

Caloric-induced nystagmus with isoelectric electroencephalogram.

Caloric vestibular testing induced nystagmus in a patient with an isoelectric electroencephalogram after cardiopulmonary arrest. This has been demonstrated previously in patients in a chronic persistent vegetative state with intact brainstem reflexes, but never in a patient with an isoelectric electroencephalogram. Animal studies indicate that the quick phase of nystagmus and horizontal saccades are generated in the paramedian pontine reticular formation. The present case supports the conclusion that caloric-induced nystagmus originates in the brainstem in rudimentary form.

Brain Death

Epilepsia partialis continua associated with nonketotic hyperglycemia: clinical and biochemical profile of 21 patients.

In 21 patients, epilepsia partialis continua (EPC) was an early symptom of nonketotic hyperglycemia and occurred during an initial phase of hyponatremia and mild hyperosmolality. EPC persisted for an average of 8 days, and its duration correlated predominantly with the degree of hyponatremia. Depression of consciousness and cessation of seizures occurred with increasing severity of hyperglycemia and hyperosmolality. In 9 patients, EPC was the first symptom leading to the diagnosis of diabetes mellitus. Four patients died of serious associated illness. The majority of the patients had evidence of a localized structural cerebral lesion. Metabolic disturbances including hyperglycemia, mild hyperosmolality, hyponatremia, and lack of ketoacidosis contribute to the development of EPC in areas of focal cerebral damage.

Adult

Hypertensive cerebrovascular disease and normal pressure hydrocephalus.

A hypertensive patient with clinical and laboratory features of normal pressure hydrocephalus (NPH) but with evidence of bilateral multiple cerebral infarcts on computed tomography (CT) did not benefit from shunting. In six reported cases of hypertensive cerebrovascular disease with NPH, the result of shunting was not predictable and was generally disappointing. Laboratory criteria to predict which cases of NPH will benefit from shunting remain controversial. The chances of improvement after shunting are slight when there is CT evidence of bilateral multiple cerebral infarcts, even though other clinical and laboratory data might suggest NPH.

Aged

Computed tomography in adult-onset epileptic seizures in a city hospital population.

Computed tomography (CT) was performed on 155 patients from a city hospital population who developed seizures after age 20. CT was normal in 58 (37.4%) and abnormal in 97 patients (62.6%). A focal abnormality was seen in 71 patients (45.8%). Lesions potentially correctable by surgery were found in 24 patients (15.4%). As expected, the occurrence of abnormal CTs was higher (73%) in patients with partial seizures. Although CT is undeniably useful in evaluating the cause of seizures, no demonstrable lesion was found in a relatively large number of patients (37.4%).

Adult