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Biomedical subjects

R J Swingler

Publications and source records attributed to R J Swingler.

8 recordsLinked to original sources
PubMed1992

Western blotting analysis in patients with MS using human brain vessels as antigen.

Serum samples from patients suffering from multiple sclerosis, other neurological diseases and normal controls were screened by "western blotting" for antibody directed against proteins of human brain vessels purified from a post mortem brain. A small number of sera contained autoantibodies against some of the proteins of the brain vessels, particularly in patients suffering from MS, epilepsy and migraine. The significance of these results is discussed.

Antibody Specificity↗
PubMed1992

Motor neuron disease and polio in Scotland.

An analysis of mortality and morbidity rates for motor neuron disease (MND) in Scotland has confirmed earlier observations that the disease is more common in men and older age groups. The geographical distribution is non-uniform and related to discharge rates for all neurological diseases. Discharge and mortality rates are increasing but there has been no decline in populations who would have been vaccinated against polio.

Adolescent↗
PubMed1992

The morbidity of multiple sclerosis.

Although the clinical course of multiple sclerosis is benign in up to one-third of patients, it is important to recognize the high rate of morbidity in others. Most individuals pass through a remitting phase but in a significant proportion the clinical manifestations subsequently recur, persist or slowly progress, and disability accumulates with time. Here we describe the frequency and spectrum of morbidity in a population based cohort of patients with multiple sclerosis. These statistics will guide those providing health care resources and planning services for patients with multiple sclerosis.

Adolescent↗
PubMed1990

Demographic characteristics of multiple sclerosis in south east Wales.

The non-uniform distribution of multiple sclerosis in the United Kingdom has been attributed to genetic, exogenous and selective factors. Within the county of South Glamorgan the disease is most prevalent amongst middle-aged married or divorced caucasian women, born in England rather than Wales, occupying flats located in affluent communities with superior amenities where rates of owner occupation are high. The disease is least prevalent amongst young single Welsh-born or non-caucasian males living in rented accommodation located in less affluent communities with a higher population density. These observations may, in part, be related to superior ascertainment of the former group, but some, as yet unidentified, characteristic of the environment may also be relevant.

Adolescent↗
PubMed1990

Features of multiple sclerosis in older patients in South Wales.

Multiple sclerosis (MS) may occur outside the commonly accepted age range. Data relating to features of MS in a population in South Wales have been analysed to find features which characterise older patients. The older patients are more severely disabled due to the accumulation of visual defects and motor signs and symptoms. The course of the disease is marked by single localised attacks with long remissions. Those with onset over 50 years deteriorate more rapidly, but in those who were over 50 at the time of interview, this did not occur. It is suggested that there is no essential difference in MS in older patients, but there may be features which reflect normal ageing and diseases commoner in old age.

Adolescent↗