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Biomedical subjects

R J Zochowski

Publications and source records attributed to R J Zochowski.

At least 19 recordsLinked to original sources
PubMed1993

[Effect of treatment with indobufen on blood viscosity indices and exercise tolerance in patients with coronary disease].

The study included 20 patients aged from 50 to 65 years with stable coronary disease. In all patients exercise ECG test in Quinton moving track was performed before the treatment, and after one, three, and eight weeks of therapy. Besides that, before the treatment, and after each exercise, platelet aggregation, viscosity of whole blood and plasma, and filtration time of 1 ml of whole blood were evaluated. It was found that already after one week of treatment indobufen caused a decrease of platelet aggregation, reduction of viscosity of whole blood and plasma, and improvement of erythrocyte compliance which favourable effects increased with the continuation of the therapy up to eight weeks. At the same time as a result of eight weeks of treatment a significant improvement was achieved of exercise tolerance in the treated patients.

Adult↗
PubMed1990

[The effect of combined treatment in chronic congestive heart failure with digoxin, furosemide and pentoxifylline upon blood viscosity].

21 patients with symptoms of chronic congestive heart failure, NYHA classes II-IV, were treated with digoxin and furosemide for at least 14 days. In the next stage of the therapy they additionally received a 200 mg intravenous dosage of pentoxifylline and continued to take pentoxifylline orally for the period of at least 14 days. Before the therapy and after each of its stages echocardiography was performed, rheological and gasometric indices of the blood were determined and the level of physical efficiency was assayed in each patient according to NYHA classification. After the digoxin-furosemide treatment there was a significant increase in viscosity of the blood caused by its condensation. Simultaneously there could be observed a significant increase in physical efficiency in patients and also an improvement in some of indices of the left ventricular functions and in gasometric characteristics of the blood. Due to intravenous administration of pentoxifylline a decrease in blood viscosity occurred. The combined treatment with orally administered digoxin, furosemide and pentoxifylline caused a further decrease of blood viscosity, an improvement in some indices of left ventricular efficiency and gasometric characteristics of blood and also much better physical condition of the patients. The results of the present study show that in chronic congestive heart failure subjects a digoxin-furosemide treatment, besides undoubtedly advantageous haemodynamic effects, also leads to blood viscosity. The addition of pentoxifylline results the reduction of increased blood viscosity and in much better hemodynamic condition of the patients.

Adult↗
PubMed1990

[Comparison of the diastolic mitral gradient by the methods of Doppler echocardiography and heart catheterization in patients with mitral valve defect].

The aim of the study was comparison of mitral diastolic gradient determination by noninvasive Doppler echocardiography and simultaneously done cardiac catheterization. The examination was performed in 34 patients with mitral valve disease, divided into 3 groups: I--isolated mitral stenosis--9 patients, II--mitral stenosis and mild or moderate mitral regurgitation (+1, +2 according to Sellers)--15 patients, III--mitral stenosis and severe mitral regurgitation (+3, +4 according to Sellers)--10 patients. In group I and II good correlation between results obtained with both methods were observed. Nevertheless, in the group III in patients with severe mitral regurgitation significantly greater mitral valve gradient was found in Doppler examination as compared to the cardiac catheterization (p less than 0.05).

Adult↗
PubMed1986

Intravenous clonidine treatment in acute myocardial infarction (with comparison to a nitroglycerin-treated and control group).

This study describes the effects of intravenous clonidine treatment in a group of 24 patients with acute myocardial transmural anterior and/or lateral wall infarction. Clonidine was administered as a bolus injection of 1-2 micrograms/kg body weight and repeated every 1-3 h. The range of the time of administration varied from 20 min to 4 h, with the maximal range of doses from 37 to 150 micrograms, depending on the hemodynamic status. The effects were measured by precordial electrocardiographic mapping and compared with similar effects obtained in the nitroglycerin-treated group (30 patients) and a control group (12 patients). A large decrease in ST segment elevation was observed. The ST reduction after 24 h was 37% of initial value (compared with 52% in the nitroglycerin group, 140% in the control group); after 48 h there was a 30% reduction (compared with 55% in the nitroglycerin group and 120% in the control group). After 24 h there was a fall in NST of 45% (71% with nitroglycerin and 145% in the control group); after 48 h there was a 41% decrease (compared with 65% in the nitroglycerin group and 142% in the control group). New Q waves increased after 24 h to 135% of the initial value (compared with 122% in the nitroglycerin group and 156% in the control group); after 72 h this increased to 137% (128% in the nitroglycerin group and 167% in the control group). Detailed analysis revealed a correlation between the dosage and favorable dynamics of mapping parameters.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗