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Biomedical subjects

R Janda

Publications and source records attributed to R Janda.

43 records · Page 3Linked to original sources
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[Neurological disorders of vitamin B12 deficiency].

It is almost two hundred years since the description of the first neurological disorders in vitamin B12 deficiency. In spite of that, not all the aspects of the biological effect of the vitamin have been explained. It is well known, that the vitamin performs an important function in organic metabolism and two types of biochemical reactions depend on it. The haematological, gastrological and neurological disorders are the result of deficiency of that vitamin. This article deals with the neurological disorders--subacute degeneration changes of the spinal cord, polyneuropathy and psychical disorders--which accompany vitamin B12 deficiency. It also presents aetiology, epidemiology, clinical symptoms, pathomorphology and it describes the deviations which occur in accessory investigations. The authors pay special attention to the abnormalities which can occur in neurophysiological and imaging examinations made by neurologists. They concentrate on the problems of the differences, especially between multiple sclerosis and subacute degeneration. The article presents the treatment of neurological disorders with regard to different authors' opinions. The importance of the early diagnosis and treatment till regression of pathological symptoms has been particularly stressed.

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[Blood flow velocity in the anterior part of the circulus arteriosus in ischemic stroke: correlation with Doppler ultrasonography of the internal carotid arteries].

UNLABELLED: The correlation was studied between blood flow velocity in the anterior part of the circulus arteriosus and the condition of the internal carotid arteriess in their extracranial course studied by Doppler USG. The arteries in the anterior part of the circulus were studied in 100 patients with ischemic stroke, and in 50 controls without cerebrovascular disease. Only strokes in the area of the middle cerebral artery (MSC) were considered. The patients were divided into 4 subgroups depending on the condition of the extracranial portion of the carotid internal arteries (ICA): 1. with normal pattern of arteries in USG-duplex, 2. with narrowing without haemodynamic importance, 3. with high-grade stenosis and haemodynamic disturbances, 4. with occlusion of the ICA. Transcranial Doppler USG was carried out through a "temporal window" assessing blood flow velocity in the MCA and in the anterior cerebral arteries (ACA) on both sides. RESULTS: In subgroups 1 and 2 the mean flow velocity in MCA was reduced on the side of the stroke. In groups 3 and 4, apart from reduced flow velocity in the MCA on the side of the stroke, increased velocity on both sides was found in the ACAs. CONCLUSION: The degree of ICA narrowing in its extracranial part was influencing the condition of intracranial circulation.

Adult↗
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[Neurologic signs in Addison-Biermer disease (report of 3 cases)].

The authors report three patients in whom a neurological syndrome was the first manifestation of Addison-Biermer disease. In the first case a paraneoplastic neurological syndrome was suspected, in two other cases the initial tentative diagnosis was multiple sclerosis. The correct diagnosis was reached after a prolonged diagnostic procedure and after ruling out of other diseases. The course of the disease was very serious in all cases leading to death of one patient despite intensive treatment (postmortem examination confirmed the diagnosis). In the second case the neurological syndrome failed to regress completely. The authors stress the necessity of considering this aetiology in neurological syndromes of atypical pattern and course.

Adult↗
PubMedDate not supplied

[Subarachnoid hemorrhage due to conus medullaris ependymoma].

A case of conus medullaris tumour (ependymoma) is reported in which the presenting symptom was subarachnoid haemorrhage, which has left bladder dysfunction. 70-year-old patient was admitted to the Department of Neurology due to symptoms of conus medullaris lesion with retention of urine and diminished pain sensitivity in perianal zona. He had been hospitalized 30 years ago due to vomiting, headache and pain in lumbar region. The cerebrospinal fluid examination confirmed the diagnosis of subarachnoid haemorrhage. Cerebral angiography failed to show the source of bleeding. Myelography and spinal arteriography showed nor tumour neither vascular malformation. Only MRI examination performed after 30 years following the first symptoms of tumour made possible the correct diagnosis--tumour in vertebral canal at L1-L2 level compressing conus medullaris. Surgical procedure confirmed the diagnosis. Histopathological examination--ependymoma myxopapillare.

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