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Biomedical subjects

R Jankowska

Publications and source records attributed to R Jankowska.

17 recordsLinked to original sources
PubMed1989

Interferon synthesis by peripheral blood leukocytes of patients with bronchial asthma.

Interferon production by leukocytes of 28 bronchial asthma patients and 27 normal subjects was examined using whole blood technique. Interferon production in blood samples was induced by classical inducers and the obtained interferons were tested in A549 cells using EMC virus as challenge. Leukocytes from both atopic and infectious asthma patients showed decreased ability to interferon production in comparison to healthy donors. In atopic asthma statistically significant differences in interferon production induced by NDV, PHA + PMA and LPS were observed. In the case of infectious asthma lower amounts of interferon were noted after stimulation with LPS and PHA + PMA. A decrease in spontaneous interferon production was also observed.

Asthma↗
PubMed1988

Effect of antihistamines on interferon production by leukocytes from sensitized and non-sensitized mice.

The effect of four antihistamines (Intal, Zaditen, Tavegyl, Benzhydramine) on interferon production in mice was investigated. The agents were administered in vivo to ovalbumin-sensitized and non-sensitized mice, or in vitro to isolated peritoneal cell cultures. The cells were induced for interferon production with Newcastle virus. It was shown that Tavegyl and Benzhydramine, both after in vivo and in vitro administration, inhibit interferon production, while Intal and Zaditen had no effect.

Animals↗
PubMed1988

Modulation of interferon synthesis with the drugs applied in bronchial asthma.

Investigations were carried out on 28 patients with nonatopic bronchial asthma treated with glycocorticosteroids or antibiotics and on 15 patients with atopic bronchial asthma treated with Alavac S vaccine. Leukocytes isolated from these patients by the method of Mogensen and Cantell were induced with Newcastle disease virus for interferon production, IFN was tested in the culture of human fibroblasts (HAT). The production of leukocytic IFN in glycocorticosteroids- and antibiotics-treated patients was shown to increase. On the contrary, the leukocytes from the patients 3 months treated with Alavac S exhibited suppressed production of the interferon.

Adult↗
PubMed1988

Production of interferon by leukocytes from patients with atopic and nonatopic asthma.

Investigations were carried out on 62 patients with atopic and nonatopic asthma and 70 normal individuals. Leukocytes isolated according to the method of Mogensen and Cantell, were induced for interferon production with Newcastle virus, H strain for 24 h at 37 degrees C in a tube culture placed in rolling drum. Interferon was assayed in the culture of human fibroblasts (HAT). Leukocytes from patients with both types of asthma had reduced interferon-inducing activity. At acute viral infection, a transient increase of interferon titer was observed. The titer, however, never reached the values of interferon induced in leukocytes from healthy individuals.

Asthma↗
PubMed1986

The course of influenza virus infection in mice sensitized with hen's egg albumin.

The present study was undertaken to test the effect of sensitization of mice with ovalbumin on the course of influenza virus infection. It was shown that the endogenous interferon level as well as degree of degranulation of lung mast cells were higher in sensitized and influenza virus-infected mice than in infected and nonsensitized ones. Also, lung cells of mice subjected to influenza virus effect in vitro revealed higher degranulation degree.

Animals↗
PubMedDate not supplied

[Circulating immunologic complexes in blood sera of bronchial asthma patients treated with attenuated vaccine].

The study included 20 patients (8 males and 12 females) with non-atopic bronchial asthma treated with attenuated vaccines. Circulating immune complexes were assayed with two methods prior to and after the treatment of each patient. No increase in serum circulating immune complexes was produced after the treatment. Clinical improvement was noted in 75% of treated patients. Circulating immune complexes were detected in the blood serum of three patients treated without an effect.

Adult↗