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R Jaszewski

Publications and source records attributed to R Jaszewski.

51 records · Page 3Linked to original sources
PubMed1983

Giant duodenal ulcers. Successful healing with medical therapy.

Giant duodenal ulcers (GDU) have been associated with a high incidence of morbidity and mortality unless early operative intervention is undertaken. There are few published reports of successful medical management of GDU. Therefore, we reviewed 14 consecutive patients with GDU at our institution. Excluding the following cases: Two patients who had elective surgery, two patients who died from unrelated causes, and one patient who initially presented with a complication of GDU, complete healing was accomplished in eight of nine patients with cimetidine, antacids, and close observation. We conclude from our review that uncomplicated GDU can be successfully treated with medical therapy.

Adult↗
PubMed1978

[Diagnosis of pulmonary hypertension by means of noninvasive techniques (author's transl)].

On 33 patients with mitralic heart disease (III and IV class N.Y.H.A.) we have carried out polimechanical investigations (ecg, fcg, x-ray examination, external heart impulse record) and the following parameters was determined: 1) interval Q-I sound; 2) interval II sound-OS; 3) Wells's index; 4) Q-I sound/II sound-OS ratio; 5) duration of electromechanical systole of right ventricle; 6) duration of external heart impulse; 7) relative amplitude of E and E1 as percentage of amplitude from E point to nadir point; 8) relaxation isovolumetric time of right ventricle; 9) medium value of pulmonary capillary pressure, total pulmonary resistances, and area of mitral valve. The results demonstrate that there is a correlation between these parameters and the pulmonary blood pressure, whose value is possible to determine as well as haemodynamic investigation. The data indicate validity of non invasive techniques in detecting pulmonary hypertension in mitralic valve diseases.

Adult↗
PubMedDate not supplied

Moderate systemic hypothermia and cold crystalloid cardioplegia influence on myocardial ischemic and revascularisative injury.

The number of granulocytes, their ability to generate superoxide anion (O2-) and the activities of Cu, Zn--superoxide dismutase (SOD-1), glutathione peroxidase (GSH-Px), catalase (CAT) as well as malonyldialdehyde (MDA) concentrations in erythrocytes in the blood extracted from the venous sinus and aorta under coronary artery bypass were examined with the use of St. Thomas Hospital cardioplegic solution. Specimens at the peak of ischemia of the right atrium for ultrastructural examination of the endothelial cells of capillary vessels and sarcomers were taken. The blood was obtained during cardiopulmonary bypass (CPB) before the aorta clamping and immediately after aorta declamping (peak of ischaemia) between 1-3 minute and 10-13 minute of reperfusion. Increase of the number of granulocytes both in the coronary sinus and aortal blood at all examined intervals as well as decrease in the number of ones in sinus compared with aortal blood was noted. The ability to produce superoxide anion radical decreased at the peak of ischemia and during reperfusion. The activity of SOD-1 was lower both after the period of ischemia and reperfusion. The increase in aortal blood activity during reperfusion was characteristic of GSH-Px; the activity was higher in the blood sample from the coronary sinus taken during ischemia and initial reperfusion. With the exception of the initial reperfusion the activity of CAT diminished in all observed cases. MDA concentration did not demonstrate any significant changes with the exception of the initial reperfusion in the aortal blood and later towards the end of reperfusion in the blood from the coronary sinus. Ultrastructural studies indicated overhydration of the cells both in the endothelium and the intercellular space. The obtained data demonstrate that the applied cardioplegic solution protects the myocardium from harmful effects of reactive oxygen species produced as a result of ischemia and reperfusion.

Adult↗
PubMedDate not supplied

Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells.

We have investigated the chemopreventive role of curcumin in gastrointestinal cancers by studying the regulation of proliferation and apoptosis in gastric (KATO-III) and colon (HCT-116) cancer cells. Curcumin inhibited cell proliferation and induced G2/M arrest in HCT-116 cells. Investigation of the levels of cyclins E, D and B by immunoblot analysis showed cyclin B level was unaffected, whereas cyclin D and E levels declined with curcumin in both cell lines. Investigation of cyclin-dependent kinases, Cdk2 and Cdc2, showed activity of Cdc2, but not Cdk2, increased markedly in response to curcumin. In both cell lines, immunoblot analysis indicated that curcumin caused induction of apoptosis as evidenced by cleavage of PARP, caspase-3, and reduction in Bcl-XL levels. Curcumin also stimulated the activity of caspase-8, which initiates Fas signalling pathway of apoptosis. Curcumin therefore appears to exert its anticarcinogenic properties by inhibiting proliferation and inducing apoptosis in certain gastric and colon cancer cells.

Antineoplastic Agents↗