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Biomedical subjects

R Juhl

Publications and source records attributed to R Juhl.

5 recordsLinked to original sources
PubMed1984

Oral malignant and premalignant changes in 'Shammah'-users from the Gizan region, Saudi Arabia.

A survey of the oral mucosa in 661 of the people living in various geographical locations of the Gizan region has been carried out. Mucosal lesions compatible with 'oral leukoplakia' have been found to affect approximately 68% of the users of the native snuff known as 'Shammah'. The lesions were almost always at the site where 'Shammah' was habitually held. Histological examination of biopsy specimens obtained from 29 different individuals revealed squamous cell carcinoma in 7 cases and carcinoma in situ in 2 cases, whereas the remaining specimens showed ortho- and para-hyperkeratosis, some of which also had premalignant changes. The results of this study point to a possible causal relationship between the use of 'Shammah' and the development of oral premalignant and malignant lesions among snuff-dippers in the Gizan region.

Adolescent↗
PubMed1976

Tardive dyskinesia.

The etiology, pharmacology, treatment and possible prevention of tardive dyskinesia (TD) are discussed. This neurological disorder, characterized by involuntary movements of the lips, jaws and tongue, can occur as a result of short-term antipsychotic drug therapy, but usually occurs after long-term treatment. Phenothiazines, the thioxanthines, butyrophenones, dibenzoxazepines and dihydroindolines also posess the potential for inducing TD. Methods of treatment of TD with dopamine-depleting agents, dopamine-blocking agents and cholinomimetics are discussed. Despite the apparent effectiveness of some drugs in the treatment of TD, it should be kept in mind that most of the studies demonstrating drug effectiveness involved a small number of patients.

Choline↗
PubMed1973

Tryptophol formation by Zygosaccharomyces priorianus.

Zygosaccharomyces priorianus converted L-tryptophan to tryptophol and to small quantities of indole-3-acetic acid. Neither tryptophol nor indole-3-acetic acid was metabolized when added separately to growing cultures. The possible intermediacy of indole-3-pyruvic acid, indole-3-acetaldehyde, and tryptamine in the degradation of L-tryptophan was tested by feeding these compounds to Z. priorianus and Saccharomyces cerevisiae. Indole-3-pyruvic acid and indole-3-acetaldehyde were converted to tryptophol and indole-3-acetic acid, with the latter accumulating only in small amounts. Tryptamine was converted to its N-acetyl derivative by these organisms. A qualitative study was made on the metabolism of L-phenylalanine, L-tyrosine, and L-5-hydroxytryptophan by these organisms. Like L-tryptophan, these amino acids were metabolized to their respective alcohol and acid derivatives. Of a large number of organisms tested, the yeasts possessed the highest capacity for degrading L-tryptophan to tryptophol.

5-Hydroxytryptophan↗