PubMed Health⌕ Search

Biomedical subjects

R K Cochran

Publications and source records attributed to R K Cochran.

4 recordsLinked to original sources
PubMed1996

Neonatal thrombocytopenia caused by passive transfer of anti-PLA1 antibody by blood transfusion.

A premature male infant with hyaline membrane disease received a 34 ml transfusion of packed erythrocytes from a CPDA1 blood unit on day 2 with no adverse consequences. On day 34 he was given a transfusion, and the platelet count decreased. Intravenous immune globulin therapy was initiated and the platelet count steadily increased. Human leukocyte (HLA) antigen and platelet antibody testing showed that the thrombocytopenia was due to passive transfer of platelet-specific antibody from the blood donor.

Antibodies↗
PubMedDate not supplied

Paraben-associated autoanti-Jka antibodies. Three examples detected using commercially prepared low-ionic strength saline containing parabens.

Three examples of autoantibodies with Jka specificity are reported. They all react preferentially by low-ionic strength salt (LISS) techniques, but only in the presence of parabens (butyl, ethyl, methyl, and propyl esters of p-hydroxybenzoate) or certain other neutral aromatic compounds. They were detected through the use of commercially prepared LISS solution containing parabens as preservatives. While it is unlikely that these autoantibodies are of clinical significance, the parabens can now be added to the list of reagent preservatives that may give rise to anomalous serologic reactions.

Adult↗
PubMedDate not supplied

Protothecal olecranon bursitis: treatment with intrabursal amphotericin B.

A patient is described from whom repeated olecranon bursa fluid cultures yielded Prototheca wickerhamii. Following intrabursal instillation of amphotericin B, the cultures became negative. There was no progression of infection or adverse consequences of this treatment. Review of the literature regarding this unusual infection reveals seven reported cases of protothecal olecranon bursitis. Five cases from which sufficient information was provided were diagnosed by histologic examination of excised bursa that showed the characteristic sporangia.

Amphotericin B↗