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Biomedical subjects

R K Goel

Publications and source records attributed to R K Goel.

At least 73 records · Page 4Linked to original sources
PubMed1986

Anti-ulcerogenic effect of banana powder (Musa sapientum var. paradisiaca) and its effect on mucosal resistance.

Orally administered banana pulp powder (Musa sapientum var. paradisiaca) was shown to have significant anti-ulcerogenic activity in rats subjected to aspirin, indomethacin, phenylbutazone, prednisolone and cysteamine and in guinea-pigs subjected to histamine. Banana powder not only increased mucosal thickness but also significantly increased [3H]thymidine incorporation into mucosal DNA. Relative to untreated control sections, histological studies showed that banana treatment increased staining by alcian blue in the apical cells with staining noted in the deeper layers of the mucosal glands. Banana-treated and control sections were also stained for DNA by the Feulgen reaction. The banana-treated sections showed a greater aggregation and intensity of pink spots when compared to controls. The present study suggests that banana powder treatment not only strengthens mucosal resistance against ulcerogens but also promotes healing by inducing cellular proliferation.

Animals↗
PubMed1986

A case of leucocoria caused by visceral larva migrans.

A four-year-old boy was seen in the Eye Department at the Queen Elizabeth Military Hospital, Woolwich, because his parents had noticed that his right pupil appeared white. The diagnosis of toxocaral endophthalmitis was later made. The pathogenesis and management of infestation by Toxocara species are described.

Animals↗
PubMed1982

The effect of a traditional preparation of copper, tamrabhasma, on experimental ulcers and gastric secretion.

Use of a traditional preparation of copper, tamrabhasma, has been suggested in Ayurvedic texts for peptic ulcer. The anti-ulcerogenic effect of copper per se has not been reported in the literature. In the present study the anti-ulcerogenic effect of tamrabhasma was observed in 8-h immobilised, 4-h pylorus-ligated, and aspirin-induced gastric ulcers in rats. The anti-ulcerogenic effect of the drug was also studied in histamine-induced gastric and duodenal ulcers in male guinea pigs. The minimal oral effective anti-ulcerogenic dose of tamrabhasma has been determined to be 1 mg/kg. The drug in this dose caused a decrease in the total acid and pepsin output and an increase in the carbohydrate/protein ratio, indicating increased mucus secretion in the gastric secretion of rats. Acute (1 g/kg, orally) and sub-acute (100 mg/kg, orally, for 7 days) toxicity studies did not show any toxicity including any histological or biochemical evidence of liver or kidney toxicity. The results of the present experimental studies thus lend credence to the suggested use of tamrabhasma in amplapitta, a condition resembling peptic ulcer.

Animals↗