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Biomedical subjects

R K Jensen

Publications and source records attributed to R K Jensen.

35 records · Page 2Linked to original sources
PubMed1986

Body segment mass, radius and radius of gyration proportions of children.

The segment inertial parameters of children are fundamental to the analysis and simulation of their movements. Generally it has been recognized that adult parameters cannot be extrapolated and most of the anthropometric data on children are of little or no use for determining inertias. Consequently, there have been few studies of children's kinetics. In response to this problem a longitudinal investigation, the Laurentian Study of Biomechanical Development, was launched and in this paper the effects of growth on selected segmental size and inertial parameters are reported for boys between the ages of 4 and 15 yr. The twelve subjects, representing heterogeneous body types were followed over 3 yr for a total of 36 observations. Elliptical zones 2 cm wide were used to model the body and segment inertias calculated using segment densities from the literature. These inertias were the mass, moment of inertia and mass centroid location for a fourteen segment planar representation of the body. The general accuracy mean error based on body mass was 0.203% which is consistent with reports from similar studies and techniques. Plots of segment mass proportions with respect to age showed a decrease in the head proportion balanced by increases in the thigh, shank, foot and upper arm proportions in particular. The trends for each segment were consistent with the trends for linear measures reported in the anthropometry literature. Radius proportions to the mass centroid and radius of gyration proportions were also plotted and showed smaller but consistent changes with respect to age. Linear regressions were then fitted to the distributions and standard errors calculated. The magnitude and slope of the regressions were for the most part consistent with a reported cross-sectional study of Japanese children. Where data were available, predicted parameters were compared with the reported parameters for a 12 yr old analyzed using a different mathematical model. Comparisons were also made between the predicted parameters at 15 yr and the reported parameters for healthy young adults who had been scanned using a gamma-radiation technique. For most parameters there was either good agreement or differences could be explained logically. The traditionally used parameters from older cadavers were quite inconsistent with the above. The variances of the 36 observations about the regression lines as indicated by the standard errors were small. As an illustration of the effect of these variances, the trunk parameters for a 10 yr old performing a standing jump for distance were decreased by 1 S.E. and this matched by increases for the thigh, shank and head.(ABSTRACT TRUNCATED AT 400 WORDS)

Age Factors↗
PubMed1986

Sequential study on the synergistic effects of 2,2',4,4',5,5'-hexabromobiphenyl and 3,3',4,4',5,5'-hexabromobiphenyl on hepatic tumor promotion.

A sequential study was completed to determine the effect of polybrominated biphenyl (PBB) congeners on the enhancement of gamma-glutamyl transpeptidase (GGT)-positive altered hepatic foci (AHF) and the development of hepatic nodules (HN) and carcinomas. Female Sprague-Dawley rats were given a single dose of N-nitrosodiethylamine (NDEA) 24 h following a 70% partial hepatectomy. Thirty days later, rats were randomly assigned to groups and fed a basal diet or the basal diet containing 10 p.p.m. 2,2',4,4',5,5'-hexabromobiphenyl (245-HBB), 0.1 p.p.m. 3,3',4,4',5,5'-hexabromobiphenyl (345-HBB) or 10 p.p.m. 245-HBB plus 0.1 p.p.m. 345-HBB for 140 days followed by a basal diet for up to another 310 days. Rats from each group were killed 170, 240 or 480 days after partial hepatectomy. Dietary exposure to 245-HBB and 245-HBB plus 345-HBB enhanced the development of AHF and HN whereas 345-HBB alone did not. The combination of 245-HBB and 345-HBB caused a synergistic effect on the development of AHF and HN. The number of hepatocellular carcinomas was low and evenly distributed among the groups of rats fed diets containing PBB.

Animals↗
PubMed1986

The growth of children's moment of inertia.

As children grow, their moments of inertia increase. The magnitude and timing of these changes can affect the rotations of the body. The present study evaluated inter-individual differences in the transverse centroidal moment of inertia for 12 boys between 5 and 16 yr, using intra-individual data from three successive years. Segmental masses and moments of inertia were estimated using the elliptical zone model and the model then repositioned into two configurations: a layout position from a back handspring and a tuck position from a back somersault. In each case, the mass centroid and the moment of inertia about the transverse axis were calculated. With growth indexed by age, it was shown that the rate of change increases with age. For the children 10 yr and younger, the rate of change of moment of inertia was approximately 30% of the rate for the older children. Also, at each age level, there was a wide range of moments of inertia. In order to improve the prediction of moment of inertia, height and mass were tried as predictors with a noticeable improvement in correlation and linearity. The best predictor, however, was found to be the product of mass and height squared (M X H2) with correlations of 0.99 and 0.97. It is suggested that, because of the effects of growth on the moment of inertia. M X H2 could be used in conjunction with age in order to better appreciate the potential effects of change of moment of inertia.

Adolescent↗
PubMed1985

Chronic active hepatitis in 26 Doberman pinschers.

Chronic active hepatitis with increased hepatic copper concentration was diagnosed in 25 female and 1 male Doberman Pinscher dogs. Common clinical signs included polyuria/polydipsia, weight loss, anorexia, icterus, and ascites. Increased liver enzyme activities and abnormal liver function test results were the most consistent clinicopathologic changes. The dogs were assigned to 3 groups on the basis of clinical course of the disease. Group 1 dogs (n = 12) had clinical signs of advanced liver failure and died within one week. Group 2 dogs (n = 7) had less severe clinical signs of liver disease and died within one month. Group 3 dogs (n = 5) did not have clinical signs of illness or had mild clinical signs of liver disease and died 1 to 42 months after initial evaluation. One dog could not be reevaluated and another dog was alive 3 months after initial examination. Treatments consisted of supportive care for dogs in group 1, and dietary manipulations and corticosteroids for dogs in groups 2 and 3. The association of increased liver copper concentration and chronic active hepatitis is not known.

Animals↗
PubMed1985

A general Newtonian simulation of an n-segment open chain model.

This paper presents a set of general Newtonian equations which govern the simulation of movement of a body represented by n open chain links. The input for the simulation consisted of the joint moment of force histories, lengths, masses and moments of inertia, the initial absolute angular displacements and velocities and, for the fixed or constrained axis of the nth segment, the acceleration history. Angular accelerations were then determined by solving n linear equations simultaneously, and angular velocities and displacements determined by integrating forwards. The final output was in the form of a graphical display of the linked figure. Applications of the simulation were demonstrated using three-segment representations of movements of the upper and lower extremities and a five-segment representation of a jump. Good agreement was achieved between the displayed angular displacements for the original and simulated movements. The potential for varying the input data has been examined and the implications of anticipating the effects of changed torques, inertial characteristics including attached prosthetic or sports implements and/or the initial conditions for a movement are discussed.

Acceleration↗
PubMed1984

Effect of varying the length of exposure to polybrominated biphenyls on the development of gamma-glutamyl transpeptidase enzyme-altered foci.

Female Sprague-Dawley rats were fed polybrominated biphenyls (PBBs) for 15 or 140 days after a 70% partial hepatectomy and diethylnitrosamine administration (10 mg/kg body weight) to determine the effect of varying the length of exposure to PBBs on the enhancement of gamma-glutamyl transpeptidase enzyme-altered foci. fireMaster BP-6R, a commercial mixture of PBBs, was fed to rats at a dietary concentration of 100 mg/kg for 15 days or 10 mg/kg for 140 days during the promotion phase of a two-stage hepatocarcinogenesis assay. Results indicate that short term exposure to PBBs is as effective as long term exposure in enhancing the development of enzyme-altered foci.

Adipose Tissue↗
PubMed1983

Hepatic tumor-promoting ability of 3,3',4,4',5,5'-hexabromobiphenyl: the interrelationship between toxicity, induction of hepatic microsomal drug metabolizing enzymes, and tumor-promoting ability.

Female Sprague-Dawley rats were fed diets containing 0, 0.01, 0.1, or 1.0 mg/kg 3,3',4,4',5,5'-hexabromobiphenyl (345-HBB) for 140 days after a 70% partial hepatectomy and diethylnitrosamine administration (10 mg/kg body weight) to determine if 345-HBB had tumor-promoting ability in a two-stage hepatocarcinogenesis assay. Tumor-promoting ability was assessed by measuring enzyme-altered foci exhibiting gamma-glutamyl transpeptidase activity. Enhancement of enzyme-altered foci occurred only at a dietary concentration of 345-HBB (1.0 mg/kg) that was toxic. The toxic effects were decreased body weight gain, involution of the thymus, increased liver weight, histologic and ultrastructural alterations of the liver, and elevated serum concentrations of aspartate aminotransferase. 345-HBB is a strict 3-methylcholanthrene (MC) type of hepatic microsomal drug metabolizing enzyme inducer and caused a dose-related increase of cytochrome P-450. 345-HBB, at a dietary concentration of 0.1 mg/kg, caused a physiologic response in rats as determined by induction of hepatic microsomal drug metabolizing enzymes, but there was minimal evidence of toxicity and no evidence of tumor-promoting ability. Results indicate that there can be induction of MC type of hepatic microsomal drug-metabolizing enzymes without toxicity or tumor-promoting ability and that the tumor-promoting ability of 345-HBB was most likely the result of hepatic degeneration and necrosis. This finding is in contrast to previous studies in which a closely related congener, 2,2',4,4',5,5'-hexabromobiphenyl, enhanced the development of enzyme-altered foci at dietary concentrations that were not hepatotoxic.

Animals↗
PubMed1982

Effect of combined antibiotic therapy on fertility in brood bitches infected with Brucella canis.

Bitches with naturally occurring Brucella canis infection were treated with combined antibiotic therapy consisting of tetracycline, dihydrostreptomycin, and trimethoprim-sulfadiazine. After treatment, all but 1 bitch became abacteremic, and serologic titers declined for a variable length of time (3 months to 1 years). Abortion did not occur while these bitches were abacteremic. Although sequential antibiotic therapy for 6 weeks did not eradicate Brucella canis from affected bitches, it did not prevent abortion. The number of live pups whelped and weaned by treated bitches was comparable with that in bitches before they became infected.

Abortion, Septic↗
PubMed1982

Polybrominated biphenyls as promoters in experimental hepatocarcinogenesis in rats.

Female Sprague Dawley rats were fed polybrominated biphenyls (PBB) for six months after a 70% partial hepatectomy and diethylnitrosamine administration (10 mg/kg body weight) to determine if PBB could serve as a tumor promoter in a two stage hepatocarcinogenesis test system. Firemaster BP-6, a commercial mixture of PBB, and its major congener, 2,2',4,4',5,5'-hexabromobiphenyl (HBB) were used in this study. Tumor promoting ability was assessed by measuring enzyme altered foci exhibiting gamma glutamyl transpeptidase activity. Dietary concentrations of 10 and 100 p.p.m. of the mixture of PBB and of HBB were found to be promoters of hepatocarcinogenesis. The mixture of PBB had a greater tumor promoting ability than HBB.

Acyltransferases↗
PubMed1981

The effect of a 12-month growth period on the body moments of inertia of children.

The effect of growth over a 12-month period on the principal moments of inertia for the body was investigated. The body was considered to be modelled as composed of elliptical zones 2 cm wide. Twelve children between the ages of 4 and 12 years and of different body types were tested and retested after 12 months. Moments of inertia for the three principal axes were calculated. A comparison of the results for the moment of inertia about the centroidal transverse axis showed increases from 12-57%. The results for the longitudinal centroidal axis ranged from 8-92%. For most of the children these percentage changes exceeded those in the traditional indicators of age, height, and mass. The product, mass times height squared (MH2), appeared to indicate the changes more accurately. Extreme changes were noted for a 12/13-year-old undergoing pubescent growth, a 6/7-year-old ectomorph, and a 4/5-year-old endomorph. It is suggested that the extreme changes, in particular, would make rotational movements difficult and there could be an extended adaptation period.

Adolescent↗
PubMed1981

Age and body type comparisons of the mass distributions of children.

Mass distribution profiles for children were constructed using a mathematical model of the body. The model was based on the assumption that the body is composed of 2 cm wide elliptical zones of known density. The method was judged to be accurate in terms of body mass estimations with a mean error of 0.61% (N = 12). Profiles were compared across somatotypes (endomorph, mesomorph, ectomorph) for four age levels (nominally, 12-, 9-, 6- and 4 years). The profiles showed differences in mass distribution with endomorph profiles tending to peak at the mid-trunk level, mesomorphs tending to have a lower profile and peaking at the shoulder or lower chest levels and ectomorphs having an even lower profile which was relatively constant through the trunk/upper extremity region. Profiles were also compared across ages for each somatotype and were found to become more angular as the child became older due to the regional growth of structural features such as the shoulders, chest, waist, pelvis and knees. These differences and the relatively small differences for the head were accentuated by creating a hypothetical scaled curve for a 4 year old compared with a 12 year old.

Aging↗