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Biomedical subjects

R K Landow

Publications and source records attributed to R K Landow.

8 recordsLinked to original sources
PubMed1988

Naftifine cream 1% versus econazole cream 1% in the treatment of tinea cruris and tinea corporis.

Data from 104 subjects with tinea cruris or tinea corporis were evaluated in this double-blind, randomized study. The subjects applied naftifine cream 1% or econazole nitrate cream 1% to affected areas twice daily for 4 weeks. After 1 week of treatment naftifine had an overall cure rate of 19% compared with 4% for econazole (p = 0.03). A difference in favor of naftifine, although not statistically significant after the first week, persisted throughout treatment. Two weeks after the end of treatment both medications had overall cure rates of approximately 80%. Three percent of the naftifine-treated subjects had side effects compared with 13% of the econazole-treated subjects. In two subjects using econazole, the side effects were severe enough to warrant discontinuation of treatment.

Adolescent↗
PubMed1988

The interferons. A clinician's view.

Therapy with interferon remains in its infancy. At present, appropriate methods and protocols for treatment of malignant melanoma and other tumors are being formulated. The drug offers promise for patients with basal-cell carcinoma in surgically difficult or cosmetically troubling locations. Older debilitated patients might find this mode of therapy welcome compared with more destructive surgical techniques. At some later date, interferon might be useful to treat resistant warts of the palms, soles, or genitalia.

Animals↗
PubMed1988

Etretinate. A clinician's view.

Etretinate offers a new avenue for exploration and therapy of previously resistant dermatoses and tumors. Unfortunately, the drug most often suppresses and rarely cures any given condition. Because of its toxicity, a majority of patients are unable to continue on long-term therapy; many request an alternative form of medication after 3 to 6 months. Perhaps this is fortunate, as the adverse reactions seem to accumulate and increase in frequency with long-term administration. Even for patients, especially young women, with conditions apparently ideally suited for etretinate, it may be wise to exhaust all other available options, including a trial of isotretinoin, before beginning etretinate.

Etretinate↗
PubMed1988

New drugs for dermatologic diseases.

Since its isolation less than 20 years ago, cyclosporine has become one of the major drugs in the armamentarium of transplant surgeons. A serendipitous event in 1979 suggested the drug might offer significant benefits in patients with psoriasis. Multiple trials have subsequently confirmed its usefulness in psoriasis at steadily decreasing dosages. Administered orally, the drug must be taken in a ritualistic fashion as it tends to sequestrate on the sides of the glass. A routine determination of blood levels becomes important in order to maintain the peak and trough concentrations within a relatively narrow window of safety. Depending on the particular assay used, significant differences in concentrations appear, making knowledge of the laboratory's normal values essential. Blood levels of cyclosporine vary with multiple drugs, including erythromycin, prednisone, and ketoconazole. The drug acts principally via its interference with the function of the helper T lymphocytes. Clofazimine (Lamprene) offers another weapon, especially for therapy of resistant pustulosis of the palms and soles.

Clofazimine↗
PubMed1988

Differential diagnosis and treatment of pigmented skin lesions.

As a result of our improved understanding of the biologic importance of the various forms of pigmented skin lesions, we now have the ability to distinguish troublesome spots from those having no medical importance. These circumstances parallel an astronomical rise in the incidence of malignant melanoma. When evaluating the skin, attention to the concepts presented here will allow a high degree of accuracy in classifying moles in the benign or malignant category. For the most part, consideration of the lesion's border, shape, color, and size provides sufficient information with which to decide when a biopsy is warranted. Moles should never be destroyed by burning or freezing. If they are important enough to be removed, histologic verification of their nature must be obtained.

Diagnosis, Differential↗
PubMed1983

Papillon-Lefèvre syndrome.

A patient, with Papillon-Lefèvre syndrome, presented with a premature loss of both deciduous and permanent teeth and hyperkeratosis palmaris et plantaris. Other abnormalities such as psoriasiform hyperkeratosis, calcification of the falx, and frequent infections can be seen. Although no etiologic factor is known for this aberration, an autosomal recessive inheritance is established. Treatment usually consists of dental hygiene only since dermatologic therapy is usually unrewarding. A new finding resulted when fibroblasts from involved gingiva were compared with either uninvolved gingiva or controlled gingiva. The protein and collagen synthesis of the involved tissue was about twice that of the latter two groups.

Cells, Cultured↗
PubMed1980

Cutaneous metastases. Report of two cases of prostatic cancer.

Less than 5 percent of internal malignant tumors metastasize to the skin. Prostatic carcinoma accounts for a small percentage of such tumors. The lesions are solid, rarely ulcerate, are few in number and are usually localized to the groin, the head, or the neck. The occurrence of cutaneous metastases from prostatic carcinoma frequently signifies well-advanced disease and portends a rapidly fatal course.

Adenocarcinoma↗