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Biomedical subjects

R K Narang

Publications and source records attributed to R K Narang.

At least 19 recordsLinked to original sources
PubMed1994

Effect of rifampicin on theophylline pharmacokinetics in human beings.

Theophylline pharmacokinetics before and after rifampicin administration was studied in 10 healthy volunteers. It was seen that Rifampicin significantly increased the volume of distribution of theophylline by 23.41% (p < 0.01) and its metabolic clearance by 47.65% (P < 0.05). This has got clinical significance in the treatment of patients of pulmonary tuberculosis with chronic obstructive airways disease where both the drugs may have to be given concurrently.

Adult↗
PubMed1989

Ventilatory functions in tropical pulmonary eosinophilia.

A study of ventilatory function in tropical pulmonary eosinophilia was carried out. Seventy five cases and 75 healthy controls were studied. Four types of ventilatory patterns were observed-restrictive (52%), mixed (33%), obstructive (4%) and normal (10.6%).

Female↗
PubMed1987

Circadian variations of the absolute eosinophil count and serum histaminase activity in tropical pulmonary eosinophilia.

Nine healthy volunteers and 25 tropical pulmonary eosinophilia (TPE) patients were used to study circadian variations of absolute eosinophil count (AEC) and serum histaminase activity (SHA). A marked circadian variation was found in AEC for healthy volunteers and TPE patients with the worst symptoms in the late evening and morning hours only; no rhythm could be detected in SHA for healthy subjects. However, TPE patients with worst symptoms in the late evening hours did exhibit a significant rhythm in SHA. Increased SHA in all TPE patients at all time-points of the 24 hour day-night cycle, irrespective of the worsening hours of symptoms in comparison to healthy controls, could be due to increased histamine production in such situations.

Amine Oxidase (Copper-Containing)↗
PubMed1987

Studies on circadian periodicity of plasma 17-hydroxycorticosteroids (17-OHCS) in tropical pulmonary eosinophilia.

Circadian periodicity of plasma 17-hydroxycorticosteroids (17-OHCS) was studied in ten healthy controls and 25 patients with tropical pulmonary eosinophilia (TPE). Subjects were synchronized for 1 week with diurnal activity from 0600 to 2200 hr and nocturnal rest; meals were taken at 0830, 1300, and 2030 hr. No medications were administered. TPE patients were divided into three subgroups of fourteen, seven, and four each according to the hour of the worsening of their symptoms. Blood samples were collected at 8-hr intervals at fixed clock hours for 24 hr, starting at 0800 in all four groups. We noted a marked rhythm in plasma 17-OHCS in controls, with significant amplitude and an acrophase at 1033 hr. Similarly, all TPE patients exhibited a definite rhythm in plasma 17-OHCS with significant amplitude irrespective of the time of worsening of symptoms, suggesting thereby no relationship between worsening of symptoms and the rhythm. Thus the circadian nature and normal concentration of plasma 17-OHCS were observed to be similar in healthy controls and TPE patients.

17-Hydroxycorticosteroids↗
PubMed1983

Hyperuricaemia induced by ethambutol.

Seventy patients with pulmonary tuberculosis and 12 healthy controls were included in a study to observe the effect of ethambutol on serum uric acid level. In ethambutol-treated cases a statistically significant increase in mean serum uric acid levels was observed in the second, third and fourth week of treatment. This increase was independent of dosage of ethambutol. However, 22 of the 52 (42%) ethambutol-treated cases showed no increase. Streptomycin was found not to potentiate the hyperuricaemic action of ethambutol. Hyperuricaemia due to ethambutol was reversed with probenicid but not by salicylates. No patient developed acute gouty arthritis although two developed arthralgia.

Adolescent↗
PubMed1977

Pharmacokinetic study of antipyrine in malnourished children.

Plasma half-life and metabolic clearance rate of antipyrine administered intravenously in a dose of 16 mg/kg body weight was studied in 10 children suffering from protein calorie malnutrition and five normal children matched in age and sex. Plasma half-life was increased and metabolic clearance rate was decreased in malnourished children (10.4 hr and 47.1 ml/hr per kg, respectively) in comparison to controls (6.3 hr and 70.1 ml/hr per kg, respectively). This observation indirectly reflects the lowered activity of microsomal oxidative enzyme of liver. Five children were restudied after nutritional rehabilitation of 17 to 25 days. Antipyrine plasma half-life decreased to 6.6 hr and metabolic clearance rate increased to 66.5 ml/hr per kg. These values were similar to those in normal children indicating biological recovery. The drug therapy in children with protein calorie malnutrition requires reconsideration in light of these observations.

Antipyrine↗