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Biomedical subjects

R K Raina

Publications and source records attributed to R K Raina.

24 records · Page 2Linked to original sources
PubMedDate not supplied

Studies on morphine analgesia.

Several agents with specific action on biologically active substances in brain were investigated for their influence on morphine analgesia. It was observed that imipramine, chlorpheniramine, and haloperidol antagonized morphine analgesia. The probable mechanism of action has been discussed.

Analgesia↗
PubMedDate not supplied

Pharmacokinetics of sustained release and conventional tablets of theophylline plus hydroxyethyltheophylline and its comparison with tablet aminophylline.

Pharmacokinetics of a sustained release (SR) and conventional formulations of theophylline plus hydroxyethyltheophylline was compared with tablet aminophylline. Time concentration curve of serum theophylline with the three formulations after single and multiple dosage schedules revealed significantly retarded absorption with the SR preparation. SR tablet was also seen to produce uniform steady state levels with fluctuation of serum concentrations within the therapeutic range for a duration of over 12 hours. In comparison, aminophylline and conventional theophylline hydroxyethyltheophylline tablets produced sharp swings in steady state levels with trough levels dipping to subtherapeutic concentrations within 4-6 hours. SR formulation, therefore, is likely provide consistent serum levels and better therapeutic control in comparison to the other two conventional tablets.

Adult↗