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Biomedical subjects

R K Tompkins

Publications and source records attributed to R K Tompkins.

At least 55 records · Page 3Linked to original sources
PubMed1984

Floating tumor debris. A cause of intermittent biliary obstruction.

Tumor debris, free-floating in the major biliary ductal system, is a cause of intermittent biliary obstruction that has previously not been recognized. Six patients had hepatic neoplasms with episodic jaundice and/or cholangitis due to floating tumor debris. Diagnosis included metastatic adenocarcinoma of the colon (n = 3), cholangiocarcinoma (n = 1), hepatocellular carcinoma (n = 1), and cavernous hemangioma (n = 1). All patients underwent biliary exploration, with hepatic resection and transhepatic intubation in two and T-tube placement in four. One patient died in the early postoperative period, and the major complication rate in the five survivors was 0%. Four of the five survivors had no further episodes suggestive of major bile duct obstruction. Our experience emphasizes the importance of distinguishing extrahepatic obstruction secondary to tumor debris from the more common causes of jaundice in patients with tumors and suggests that safe and effective palliation can be achieved in these patients.

Adenocarcinoma↗
PubMed1984

Incidence of complications with operative choledochoscopy.

A 5 year retrospective study of the use of cholangioscopy in 153 difficult biliary cases including stones, strictures, tumors, and anomalies has been reported. In the 88 patients (58 percent) who underwent both operative cholangiography and cholangioscopy, the cholangioscope revealed 11 lesions (13 percent) missed by cholangiography. In this series, eight retained stones (5.2 percent) were detected on postoperative T-tube cholangiography; of this group, two patients had previous biliary surgery, two had an associated neoplasm, and four had incomplete cholangioscopy for various reasons. Postoperative complications included transient bile drainage (8 percent), pancreatitis (8 percent), persistent jaundice (7 percent), cholangitis (5 percent), and abscess (5 percent). Comparison of an operative cholangiography-only group with a cholangioscopy-only group revealed no significant difference in the incidence of postoperative complications. Cholangioscopy did not increase postoperative complications in this study. It frequently detected lesions missed by cholangiography and helped define the nature of the lesions. The incidence of retained stones may be reduced by use of the cholangioscope in difficult biliary cases. Its routine use in common bile duct exploration is recommended.

Adult↗
PubMed1984

Prediction of pneumonia in outpatients with acute cough--a statistical approach.

Cough is the fifth most common reason for physician visits, but data on acute cough have rarely been collected in a standardized manner and have not been analyzed in a multivariate fashion. We report data on 1819 patients presenting with cough, all of whom received a standardized history and physical, and a chest X-ray. Only 48 (2.6%) were found to have an acute radiographic infiltrate (pneumonia). The prevalence of common signs and symptoms is shown for the patients with and without pneumonia. Thirty-two of these findings were significant predictors of pneumonia (p less than 0.05, one-tailed). These 32 did not include some of the expected predictors of pneumonia and did include some predictors not previously described in the literature. A diagnostic rule is developed which identifies pneumonia patients with 91% sensitivity and 40% specificity, or 74% sensitivity and 70% specificity. The study results suggest that many pneumonias could be predicted based only on the patients histories. Physician visits to determine physical findings and chest X-rays might be avoided by telephone triage, with substantial cost savings.

Acute Disease↗
PubMed1984

Community health politics: transition of the Seattle USPHS Hospital.

To achieve transition of the Seattle US Public Health Service Hospital from federal to local control, the community overcame large obstacles; the most difficult was federal preference for closing the hospital rather than incurring additional costs essential for transition. The Washington State Congressional Delegation, local officials, hospital staff, patients and numerous community volunteers--individuals and private organizations--worked together to save the hospital and secure federal resources for its transition. Going through the transition influenced the hospital as it developed a new corporate structure, designed new administrative systems, and prepared to operate in a new environment while facing an uncertain future. The hospital has continued to cope with issues arising from transition, such as operating in a competitive context while reaffirming its community service heritage. Despite the difficulties of transition, Seattle preserved a valuable community health resource.

Community Participation↗
PubMed1983

Caroli's Disease: a premalignant condition?

This study reports four new cases of Caroli's disease complicated by the development of cholangiocarcinoma. Caroli's disease appears to be a premalignant condition, but early diagnosis of malignancy in the cyst wall is difficult because signs of ductal stenosis develop slowly and treatment is often based on erroneous diagnosis of recurrent cholangitis. When carcinoma is present, operative intervention makes no difference in survival. In patients with Caroli's disease, adequate intraductal and hepatic biopsies should be obtained at the first operation. These patients should be followed carefully, and malignant growth should be suspected when cholangitis occurs despite patent anastomoses. Earlier diagnosis will obviate repeated operations in patients with malignant Caroli's disease.

Adenoma, Bile Duct↗
PubMed1983

Major hepatic resection. A 25-year experience.

Major hepatic resections were performed on 138 patients for a variety of conditions. There was one intraoperative death. Including this patient, there were 15 deaths within 30 days of the operation (operative mortality 10.9%). Important postoperative complications were intra-abdominal sepsis (17%), biliary leak (11%), hepatic failure (8%), and hemorrhage (6%). The results of 30 resections for the benign lesions, liver cell adenoma, focal nodular hyperplasia, hemangioma, and cystadenoma showed no operative mortality and low morbidity. Of 26 patients with hepatocellular carcinoma, seven died within a month of operation. The cumulative survival of the 26 at five years was 38%, and of the 19 who survived the procedure, 51%. Poor survival followed resections for cholangiocarcinoma and "mixed tumors." The five-year cumulative survival of 22 patients who had colorectal metastases excised was 31%. Apart from a patient with carcinoid, prolonged survival was rare after resection of other secondaries and after en bloc resections for tumors directly invading the liver. Hepatic resection was of value in the management of some patients with hepatic trauma, Caroli's disease, liver cysts, and intrahepatic stones.

Abdomen, Acute↗
PubMed1983

The Seattle evaluation of computerized drug profiles: effect on provider activities.

We studied whether furnishing care providers with computer-generated summaries of patients' current and past medications would reduce the time they spent on various drug-related tasks during patient visits. An observer used time-sampling methods to measure the amount of provider time spent on each of 10 activities during 166 clinic visits, some with profiles and some without them. Additional data were taken from the medical record on factors that might affect the time spent on various tasks. The results suggest that record reading time was reduced for first encounters between patients and providers in the medical clinics, where prescribing volume was highest; in other situations, no effect of profiles on record reading time was evident. Providers continued to document drug data in their progress notes, whether or not a profile was available, saving no time. Prescription writing required about one third less time when a profile was used than when a traditional prescription blank was used. Both uses of profiles for prescribing and the time saved per prescription also increased sharply with the number of drugs prescribed per visit.

Computers↗
PubMed1983

The effect of chest radiographs on the management and clinical course of patients with acute cough.

The authors studied 2018 consecutive patients with a cough of less than 1 month's duration, presenting for medical care with this problem for the first time. Chest films were taken of all of the last 1819 of these patients. After physicians had specified diagnoses and patient management plans for the last 1531 of these 1819 patients, 98 per cent of the 1531 were randomized either to a group whose chest films were then used in their care, or to a group whose chest films were not available to the physician. The results show that chest radiographs ordered by physicians resulted in potentially beneficial change in the care of only 3 per cent of patients. Only use of chest radiographs not ordered by physicians led to the appropriate addition of antibiotics to the care of patients with infiltrates, and probably to improved illness outcome. Criteria for efficient, effective use of chest radiographs in the management of patients with acute cough are needed.

Acute Disease↗
PubMed1983

The Seattle evaluation of computerized drug profiles: effects on prescribing practices and resource use.

Since 1979, all outpatient pharmacy transactions at the US Public Health Service Hospital in Seattle have been captured in a computer system which generates a profile of each patient's active and previously used drugs. We conducted a controlled trial in which patients were allocated to profile or no-profile groups while the computer continued to collect data on everyone. In all, 41,572 clinic visits made by 6,186 patients were studied. The incidence of preventable drug-drug interactions and redundancies was very low and was unaffected by profiles. For unclear reasons, prescription of two interacting drugs on the same visit was significantly more common for patients with profiles. The duration of drug-drug interaction episodes was significantly shorter for profile group patients, perhaps due to earlier detection of the error on subsequent visits. Profiles had no effect on prescribing volume or coordination of drug refill and visit schedules, but profile group patients made about 5 per cent fewer clinic visits than those in the no-profile group. In this setting, it appears that the prescribing of interacting or redundant drugs is more often due to inadequate provider knowledge than to inaccessible patient-specific drug data. Prevention of such errors would thus require a more active educational or monitoring program.

Computers↗
PubMed1982

Inhibition of pepsin activity by unconjugated bile acids. Inverse relation to number of hydroxyl groups.

The unconjugated bile acids cholic, deoxycholic, chenodeoxycholic, and lithocholic acid were each found to inhibit pepsin activity in vitro against the refined substrate n-adenosyl-L-phenylalanyl-L-3,5-diiodotyrosine (n-APDT). The degree of inhibition was inversely proportional to the number of hydroxyl substituents on the bile acid molecule. The implications of these findings in relation to the occurrence of peptic ulceration in patients undergoing Roux-Y biliary diversion is discussed.

Animals↗
PubMed1982

Factors influencing outcome in patients with postoperative biliary strictures.

We reviewed our experience from 1955 to 1979 with benign postoperative biliary strictures to determine which factors were associated with a favorable outcome. Patients operated on from 1970 to 1979 were significantly more likely (p less than 0.01) to achieve a good result (86 percent) than were patients undergoing surgery between 1955 and 1969 (68 percent). An inverse correlation (r = -0.96, p less than 0.05) was present between the number of previous repairs and the percentage of good results. Patients referred without a previous repair were most likely to achieve a good result (86 percent). Roux-Y jejunal reconstructions were associated with the best results (p less than 0.01). In recent years Silastic transhepatic stents were used in 20 patients with hilar strictures; 18 (90 percent) achieved good results. Patients stented for the shortest period (less than 1 month) were less likely to achieve a good outcome than those stented for longer periods (p less than 0.025). Patients with difficult hilar strictures who were stented for more than 9 months were more likely to have a good result if a changeable Silastic transhepatic stent was employed (p less than 0.01). This analysis suggests that early referral, Roux-Y jejunal reconstruction, judicious use of Silastic transhepatic stents, and prolonged stenting of hilar strictures will improve the outlook in patients with postoperative biliary strictures.U

Adult↗
PubMed1982

On the relationships among headache symptoms.

Headache classification has evolved through clinical experience because there are no objective findings which define causation or headache type. The resulting groupings are inconsistently defined, and may not be optimal for the study or treatment of headache patients. To determine whether the same headache types would have resulted if today's sophisticated statistical methods had been applied to standard data collected on unselected patients, 21 symptoms collected from 726 patients with acute headaches were analyzed. Five "natural' groupings or syndromes of symptoms were found in the data. Three were similar to traditional groupings: tension, migraine and cluster. Approximately one fourth of the patients had both tension and migraine symptoms, which suggests that the division of headaches into "tension' vs "migraine' has a large overlap. An "OCULAR' and a "URI' syndrome were also detected. Contrary to expectations, vascular headaches were not usually unilateral and patients with cluster headache symptoms were not usually males. The discrepancy between these findings and current perceptions may have been caused by differences in the populations or from biased patient selection in previous studies.

Cluster Headache↗
PubMed1982

Cluster analysis to determine headache types.

Cluster analysis was used to separate 726 headache patients into clusters of patients with similar symptoms. This was done to answer two questions: what "naturally occurring' groups of patients can be found? And how do these groups correspond to traditional headache types? When only two clusters were required, the best two clusters were tension and migraine-like. However, eight clusters could also be distinguished, and the migraine group then became very small. The clusters were tested for clinical interpretability by having 12 physicians name and prescribe treatment for the clusters. The suggested treatment was similar to what patients had actually received in about 2/3 of the cases but was rather different for the remainder. Further, the outcomes associated with different treatments appeared to vary by cluster. This suggests that the current method for classifying and treating headaches may not be optimal.

Adult↗
PubMed1982

Factors in management of acute cholangitis.

Ninety episodes of acute cholangitis in 66 patients have been analyzed. In 71% of the episodes, an operation was performed. Eight deaths occurred, for a patient mortality rate of 12%. Sixty-seven per cent of the operations were performed after at least 72 hours of antibiotic therapy, whereas only 17% had to be done as life-threatening emergencies within 24 hours of admission to the hospital. Although 86% of the operative deaths occurred in the group operated on more than 72 hours after admission, this was not statistically significant. However, death did correlate with failure to respond to antibiotic therapy (p less than 0.001) irrespective of time of operation. Biliary cancer and congenital lesions were etiologic for 31% of the operative cases in this series, but were responsible for 71% of the postoperative deaths (p less than 0.05). We conclude that acute cholangitis has a wide spectrum of severity and that most cases will respond to antibiotic therapy, affording the surgeon the luxury of operating in an elective fashion. Moreover, acute cholangitis complicated by failure to respond to antibiotic therapy is more likely to occur in biliary cancer and congenital lesions, and subsequently will have a poorer prognosis.

Acute Disease↗
PubMed1982

Primary sclerosing cholangitis: a heterogenous disease.

The clinical, radiologic and pathologic features of 37 patients diagnosed as having primary sclerosing cholangitis (PSC) were reviewed. Sixty-two per cent were men, and 35% had ulcerative colitis. The patients demonstrated considerable variability in their natural history and pathology. It appeared that they could be divided into four fairly distant groups (1) sclerosing cholangitis affecting primarily the distal common bile duct; (2) sclerosing cholangitis occurring soon after an attack of acute necrotizing cholangitis; (3) chronic diffuse sclerosing cholangitis; and (4) chronic diffuse sclerosing cholangitis associated with inflammatory bowel disease. It is suggested that the patients in these groups may have different etiologies, may respond to different treatment regimes, and may have different prognoses.

Biliary Tract↗
PubMed1982

Primary sclerosing cholangitis: results of an aggressive surgical approach.

Traditional management of patients with primary sclerosing cholangitis (PSC) has included steroids and/or choledochotomy plus prolonged T-tube drainage. The authors have not been convinced, however, that either of these therapies significantly influence the course of the disease. Therefore, a more aggressive surgical approach was adopted that included performance of a choledochoenteric anastomosis in all patients with PSC who had either (1) a major area of extrahepatic blockage, or (2) primary involvement of the extrahepatic bile ducts. Using this approach, 17 of 22 patients (77%) managed surgically at the UCLA Medical Center from 1974 through 1980 have undergone a choledochoenteric anastomosis. Of these 17 patients, 13 (77%) have had an excellent or good result following surgery. Four patients whose disease was confined to the common bile duct have all had excellent results (mean follow-up 49.3 months since surgery). In addition, 18 of the entire group of 22 patients (82%) are still alive, a mean of 52.2 months after operation and 64.7 months following establishment of the diagnosis. These results in 22 patients encourage the authors to continue to pursue an aggressive surgical approach for patients with primary sclerosing cholangitis.

Adult↗
PubMed1982

Phased trial of a proven algorithm at a new primary care clinic.

A previous study showed that a clinical algorithm for respiratory illnesses, consisting of a checklist, a set of instructions (logic), and computer audit/feedback, could reduce costs significantly while maintaining a high quality of care. The results of this study show that the algorithm system, developed and validated at one primary care clinic, can be successfully imported to another primary care clinic. In the present study, the algorithm system significantly improved the completeness of the medical records, reduced the use of medical tests by 20 per cent-75 per cent, and reduced non-provider costs by 36 per cent per patient visit. This study also shows that all three components of the algorithm system appear to be necessary to achieve these improvements and maintain a high quality of medical care. These results suggest that a wider use of the algorithm system for minor acute medical problems is both feasible and useful in providing high-quality cost-effective care that is auditable.

Adult↗