INCREASED SENSITIVITY OF MICROSOMES FROM PHENOBARBITAL-TREATED RATS TO SYNTHETIC MESSENGER RNA (POLYURIDYLIC ACID): LACK OF EFFECT ON RIBOSOMES.
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Liver↗
Biomedical subjects
R KATO
Publications and source records attributed to R KATO.
ROUS SARCOMA IN CHINESE HAMSTERS.
A variant of the Rous sarcoma virus induced tumors in newborn Chinese hamsters within 2 to8 weeks. The tumors grew progressively and sometimes metastasized. They were successfully transplanted in series in Syrian hamsters. The chromosomes of the tumors in the Chinese hamstersas well as of those transplanted into the Syrian hamsters were Chinese hamster chromosomes. Virus was demonstrated in the Chinese hamster tumors by injecting material from the tumors into chickens, where Rous sarcomas subsequently appeared.
Animals↗
FURTHER STUDIES ON THE INHIBITION AND STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYMES OF RAT LIVER BY VARIOUS COMPOUNDS.
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Carisoprodol↗
VARIATION IN THE ACTIVITY OF LIVER MICROSOMAL DRUG-METABOLIZING ENZYMES IN RATS IN RELATION TO THE AGE.
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Aging↗
METABOLIC FACTORS DETERMINING A HIGHER RESISTANCE TO STRYCHNINE IN GUINEA PIGS.
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Guinea Pigs↗
Phenobarbital markedly increases liver weight in Walker carcinosarcoma bearing rats.
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Animals↗
Decreased activities of liver microsomal drug-metabolizing enzymes in the rats bearing Walker carcinosarcoma.
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Animals↗
Inhibition of some microsomal drug-metabolizing enzymes by inhibitors of cholesterol biosynthesis.
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Alcohols↗
Mechanism of potentiation of barbiturates and mepbrobamate actions by imipramine.
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Barbiturates↗
Enhanced phenobarbital induction of liver microsomal drug-metabolizing enzymes in mice infected with murine hepatitus virus.
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Animals↗
Inhibition of pentobarbital and meprobamate metabolism by some 'inducers' of drug-metabolizing enzymes.
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Aminopyrine↗
The in vitro inhibition of pentobarbital metabolism by chlorpromazine.
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Chlorpromazine↗
The effect of ethionine on the increased metabolism of some drugs and increased urinary excretion of vitamin C induced by pretreatment with chloretone or phenobarbital.
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Ascorbic Acid↗
Induction of increased meprobamate metabolism in rats pretreated with some neurotropic drugs.
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Animals↗
Factors influencing induction of hepatic microsomal drug-metabolizing enzymes.
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Enzymes↗
Influence of sex difference on the pharmacological action and metabolism of some drugs.
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Antineoplastic Agents↗
Increased activity of microsomal strychnine-metabolizing enzyme induced by phenobarbital and other drugs.
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Glutethimide↗
Increase of pentobarbitone metabolism induced in rats pretreated with some centrally acting compounds.
Rats treated with phenobarbitone, phenaglycodol, glutethimide, nikethamide, meprobamate, chlorbutol and chlorpromazine showed an increased metabolism of pentobarbitone and, at the same time, a diminished sleeping-time after pentobarbitone. This effect developed 24 hr after treatment, the maximum increase in metabolism occurring after about 48 hr. The increased pentobarbitone metabolism was inhibited by ethionine injected shortly before treatment. Using a liver slice preparation, increased pentobarbitone metabolism was also observed in vitro. These results are in accord with the view that the capacity of compounds to increase pentobarbitone metabolism may be related to their ability to act directly on microsomal enzyme systems.
Animals↗