PubMed Health⌕ Search

Biomedical subjects

R Kammerer

Publications and source records attributed to R Kammerer.

30 records · Page 2Linked to original sources
PubMed1983

Immunofluorescence studies in progressive systemic sclerosis (scleroderma) and mixed connective tissue disease.

Immunofluorescence (IF) investigations of the skin were performed in thirty patients with progressive systemic sclerosis (scleroderma) and eight patients with mixed connective tissue disease (MCTD). The results show that speckled epidermal nuclear immunoglobulin deposition occurs not only in MCTD but also in true scleroderma. Granular IgM deposition at the dermo-epidermal junction of light-exposed skin was detected in both groups of patients, but six of eight MCTD patients also showed a granular IgM band in non-exposed skin. Antinuclear antibodies (ANA) were demonstrated in the sera of 96% and 100% of patients with scleroderma and MCTD respectively. The pattern of nuclear IF staining in scleroderma included dense fine speckles, large coarse speckles, threads, nucleolar and centromere staining. In MCTD, by contrast, the ANA staining pattern consisted of threads. The significance of ANA titres and immunological specificities for the in vivo reaction of serum ANA with epidermal nuclear antigens is discussed.

Adult↗
PubMed1980

[Staging of morbus Hodgkin by explorative laparotomy (author's transl)].

75 patients suffering from Hodgkin's disease underwent explorative laparotomy. This meant to correct the initial staging in a percentage of 34. There was an increase of postoperative complications in secondary laparotomies. In 4 our of 25 patients an unexpected involvement of the spleen could be demonstrated.

Adolescent↗
PubMed1979

[Experiences with primary and secondary laparotomy with splenectomy in Hodgkin's disease].

The explorative laparotomy with splenectomy belongs under adequately strong indication to the standard techniques of the dilated diagnostics and stage subdivision of lymphogranulomatosis. 61 patients of the Medical Academy Magdeburg were exploratively laparotomised from 1974--1978, of them 38 patients primarily before the beginning of the therapy and 23 patients secondarily 1--8 years after therapy. Changes of the stages before and after laparotomy, relations between affection of the spleen and histological type and primary histology, respectively, as well as weight of the spleen are discussed, postoperative complications are explained and adequate conclusions rendered.

Diagnostic Techniques, Surgical↗
PubMedDate not supplied

Comparison of the effects of immunosuppressive factors from newly established colon carcinoma cell cultures on human lymphocyte proliferation and cytokine secretion.

Tumor cells may influence the host's immune reactivity by the production of immunosuppressive factors (ISFs). In this study, the effects of ISFs derived from nine polyclonal colorectal carcinoma (CRC) cell lines on PHA-induced lymphocyte proliferation and cytokine secretion was investigated. We found that most of the culture supernatants (8/9) from CRC cell lines contained ISFs, which inhibited T cell proliferation to a variable degree in a dose-dependent manner. Comparison of T cell proliferation in the presence or absence of monocytes showed that monocytes can modulate the effects of tumor-derived ISFs on lymphocyte function. In addition, exposure of activated PBMC to the tumor cell supernatants resulted in an altered secretion of cytokines by these cells, i.e. the secretion of IFN-gamma was generally reduced while the secretion of IL-1beta, IL-2 and TNF-alpha was little affected. We further investigated the supernatants' inhibitory effects on PBMC in respect to the production of prostaglandin E(2) (PGE(2)). It was found that PGE(2) was secreted by all tumor cell cultures. Therefore this substance is probably involved in the immunosuppression in vivo. However, the secreted PGE(2) was shown not to be solely responsible for the observed suppression of lymphocyte proliferation in vitro. Our results suggest that the secretion of ISF is a common property of CRCs as demonstrated with newly established CRC cell cultures, and therefore this may also be an important immune escape mechanism of colonic carcinomas in vivo.

Cell Culture Techniques↗
PubMedDate not supplied

[The prognosis of Wilm's tumor in childhood].

From January 1974 to June 1990 33 children suffering from Wilms' tumor were treated at the Department of Pediatrics of the Magdeburg Medical Academy. The cumulative five year survival rate was 0.87. The treatment regimen depended on age of patient, stage and histological subclassification of tumor. In spite of an impressive reduction of therapy during the observation period the survival rate of patients remained high. Since 1989 the Nephroblastoma study No 9 of the European International Society of Pediatric Oncology has been applied to improve furthermore the treatment by a preoperative chemotherapy in all patients.

Antineoplastic Combined Chemotherapy Protocols↗