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Biomedical subjects

R Kania

Publications and source records attributed to R Kania.

16 recordsLinked to original sources
PubMed2005

Enhanced sodium absorption in middle ear epithelial cells cultured at air-liquid interface.

CONCLUSION: As we demonstrated previously that transcription of alpha-ENaC was correlated with oxygen tension in the culture medium, this study suggests that the increase in alpha-ENaC expression observed under ALI conditions may result from greater oxygenation of ME cells. OBJECTIVE: The physiology of the middle ear (ME) is primarily concerned with keeping the cavities fluid-free, to allow transmission of sound vibrations from the eardrum to the inner ear. ME epithelial cells are thought to play a key role in this process as they actively absorb sodium and water in order to clear any excess fluid present in the cavities. MATERIAL AND METHODS: As an air-liquid interface (ALI) model has been shown to improve differentiation and enhance sodium absorption in other respiratory epithelia, we established an ALI model for ME cells. RESULTS: ME cells cultured under ALI conditions exhibited a fourfold increase in sodium absorption, which was not related to either a metabolic effect or to enhanced morphological differentiation, but instead to an increase in expression of the alpha-subunit of the epithelial sodium channel (alpha-ENaC).

Absorption↗
PubMed2004

Vertebrobasilar occlusive disorders presenting as sudden sensorineural hearing loss.

BACKGROUND: Isolated sudden sensorineural hearing loss (SSHL) has been rarely related to vertebrobasilar occlusive disorders (VBOD). This is an important issue for both neurologists and otolaryngologists, since the management and prognosis of this type of hearing loss widely differs from that of hearing loss from other causes. OBJECTIVES: To describe the clinical characteristics and report the incidence of SSHL related to VBOD. METHODS: Retrospective analysis of clinical charts from 333 patients admitted for SSHL in a large ear, nose, and throat emergency tertiary care center from 1999 to 2002. RESULTS: Four cases (1.2%) of VBOD as the unique cause of SSHL were diagnosed among 333 patients. The most typical features of these cases were the presence of one of the following characteristics: (1) bilateral SSHL, (2) associated occipital or posterior nuchal pain, and (3) the occurrence of delayed neurologic deficits. The underlying vascular disease affected the vertebral arteries: dissection in two cases and atherosclerosis in two other cases. The audiometric features of hearing loss were endocochlear in one case, of both types in one case, and unknown in two cases. Hearing recovered partially or completely. CONCLUSIONS: Our results confirm the low incidence of SSHL related to VBOD and show that the observation of endocochlear audiometric features cannot preclude a central cause in SSHL. The clinical presentation of our cases related to VBOD emphasize that a careful follow-up of any patient with SSHL is warranted and that the presence of nuchal pain suggestive of arterial dissection in younger subjects, a past history of atherosclerosis or embolism in older patients, or the occurrence of delayed associated neurologic symptoms should be considered with particular caution in this situation.

Adult↗
PubMed2003

[Vascular complications after acoustic neurinoma surgery].

OBJECTIVE: To report six cases of vascular complications occurring after acoustic neuroma surgery and to discuss the postoperative signs and symptoms that should alert the surgeon, in order to undertake the appropriate treatment as soon as possible. METHODS: Four hundred thirty-two cases of acoustic tumors operated by the same surgeons between January 1991 and December 2000 were reviewed. RESULTS: Six cases of vascular complications were identified: one case of cerebral vasospasm secondary to persistence of subarachnoid blood after injury to Dandy's vein; three cases of arterial infarction giving rise to a partial anterior inferior cerebellar artery (AICA) syndrome with an unusual nystagmus in two cases (ipsilateral in one patient and strong controlateral in one patient presenting preoperative vestibular areflexia); one case of hematoma of the cerebello-pontine angle (CPA) causing strong ipsilateral nystagmus; and one case of venous infarction of the cerebellar vermis secondary to accidental sinus thrombosis. CONCLUSIONS: Vascular complications after acoustic neuroma surgery are potentially devastating and should be identified as early as possible. Rapid extubation is recommended for systematic neurologic assessment. Among abnormal signs and symptoms that should alert the surgeon, marked nystagmus ipsilateral to the operated side or contralateral in patient presenting preoperative vestibular areflexia appears to be of great value.

Adult↗
PubMed1998

[En bloc resection of the carotid axis in epidermoid carcinoma of the head and neck. Retrospective analysis of 7 cases].

En bloc resection of carotid artery involved by squamous cell carcinoma was performed in 7 patients from 1993 to 1997. Cerebral tolerance was tested with qualitative evaluation of cerebral blood flow during preoperative balloon test occlusion of the internal carotid artery. Four patients later underwent permanent carotid occlusion prior to en bloc resection, 2 patients underwent carotid ligation without reconstruction and one patient underwent carotid resection associated with carotid reconstruction. The preliminary neurovascular and carcinologic results are presented. One patient had definitive stoke postoperatively. Follow-up ranged from 3 to 34 months. Two patients died by the 6th and 26th postoperative month respectively. Among the remaining 5 patients, tumoral recurrence occurred in two. Two patients have survived more than 2 years, but one of them had local recurrence and distant metastases. Considering these data and the review of the literature, selection of patients after carcinologic and cerebral tolerance evaluation is important in order to improve survival and quality of life of these patients.

Adult↗
PubMed1994

[Report on 3061 laparoscopic cholecystectomies].

The results of 3061 laparoscopic cholecystectomies made by 58 surgeons in nine departments--feasibility 88.9%, low morbidity rate (n = 2071) 11.8%, high morbidity rate 2.48%, mortality rate 0.22%, residual choledocholithiasis 1.36%, preoperative use of endoscopic methods 1.0%, revision in a total of 1.8%--are as a rule less favourable than summarized statistical data from abroad. Similarly as in data abroad the incidence of biliary lesions is not satisfactory--0.65%. The incidence of fistulas (0.13%) revisions on account of haemorrhage (0.29%) and surgical preoperative accidents (0.24%) was lower. Departments which use thermocoagulation have a significantly lower incidence of lesions (0.14% - p < 0.06) than teams working with electrocoagulation.

Cholecystectomy, Laparoscopic↗
PubMed1992

[Persistent ductus omphaloentericus as a cause of ileus in children].

The authors describe a case of ileus in a 16-month-old child caused by Meckel's diverticulum. The symptoms leading to diagnosis were vague, partly masked by concurrent respiratory disease. In the discussion the authors mention possible complications associated with this anomaly.

Humans↗
PubMed1991

[Surgery of inguinal hernia using a modification of McVay's method].

The authors demonstrate the procedure and results of a modified method of surgery of inguinal hernias. Mc Vay's method resolves, contrary to other methods used in this country, also problems of the posterior wall of the inguinal canal. The operation involves: 1. closure of the defect in the fascia transversalis, 2. relieving incision of the sheath of the m. rectus abdom., 3. dislocation of the outlet of the funiculus on the cranial side, 4. placement of the funiculus between the lamina of the aponeurosis of the m. obliquus abdom. The authors use this method for operation of inguinal hernias since 1971. They present a group of 455 patients operated during the last five years, incl. results.

Female↗
PubMed1990

[Surgical treatment of chronic pain in the area of the Achilles tendon].

In 109 patients with painful Achilles tendons 139 primary operations were made. Peritenonectomy and scarification of the tendon were performed. As a criterium of success the ability to pursue the original sports activities was used. Of 109 subjects addressed 91 responded. Of these 63 pursue sports activities without restrictions, 20 have slight difficulties but pursue sports activities as before, six undergo further treatment, four changed the sports discipline and two abandoned sports. Indication for operation is based on a group of symptoms: morning stiffness, a positive finding on palpation of the tendon and failure of conservative treatment. In the authors' opinion the cause of complaints are inflammatory degenerative changes of the tendon and peritenon which prevent free movement of the tendon as a result of chronic overburdening.

Achilles Tendon↗
PubMed1980

Gastroesophageal cardiac fistula due to perforation of an esophagogastric anastomotic ulcer into the left atrium.

A case of gastroesophageal cardiac fistula is presented. Resection of carcinoma of the gastroesophageal junction was followed by the development of a penetrating ulcer at the anastomosis site with perforation into the left atrium. Candida albicans was demonstrated growing along the tract. There was severe organizing fibrinous pericarditis and multiple microabscesses in the brain. No food emboli were found.

Brain↗