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Biomedical subjects

R Khattech

Publications and source records attributed to R Khattech.

17 recordsLinked to original sources
PubMed1996

[Primary leiomyosarcoma of the small intestine in a child].

BACKGROUND: Leiomyosarcomas of the digestive tract are very rare in children. They must be differentiated from benign tumors (leiomyoma, schwannoma...) and from other malignant tumors, sometimes with the aid of immuno-histochemical study. CASE REPORT: A five-year old girl suffered from an abdominal mass associated with fever and alteration of the general condition. An ileal tumor, 8 cm in diameter, was resected. Histological and immunohistochemical studies (anti-vimentin antibodies, anti-actin antibodies and PS100) confirmed the diagnosis of leiomyosarcoma. Uncomplete adjuvant chemotherapy failed to prevent relapse of the tumor. CONCLUSION: This case confirms the bad prognosis of such a tumor.

Child, Preschool↗
PubMed1995

Melanin production in medullary thyroid carcinoma.

A case of melanin-producing medullary thyroid carcinoma is reported in a 51-year-old man. Histologically, the tumour had a typical pattern of medullary thyroid carcinoma with numerous scattered pigmented cells which contained large amounts of melanin pigment as confirmed by bleached Fontana-Masson stain. Immunohistochemical staining revealed positivity of almost all tumour cells for calcitonin and chromogranin, whereas S-100 protein and HMB-45 staining was positive only in the pigmented tumour cells. This finding confirms the ability of medullary thyroid carcinoma cells to have multidirectional differentiation, although melanocytic differentiation remains an exceptional phenomenon.

Amyloid↗
PubMed1995

[Microcystic adenoma of the pancreas].

Microcyst adenomas of the pancreas are rare tumours with characteristic cysts lining the cubic and cylindric epithelia with a clear cytoplasm rich in glycogen. Unlike, mucinous cyst adenomas, there is no tendency toward malignancy. We report a case in a 58-year-old woman and emphasize the importance of precise pre- or per-operative diagnosis in order to avoid excessive exeresis for benign tumour. Certain authors propose abstention and follow up.

Cystadenoma, Serous↗
PubMed1995

[Breast myoepithelioma. Report of a case].

Myoepithelial cell tumors of the breast are rare. They present diagnostic difficulties not only on frozen sections but also after fixation and paraffin embedding. These tumors can give rise to a wide range of clinical evolution... Treatment vary from simple excision for myoepitheliosis to mastectomy with axillary node dissection for malignant myoepitheliomas. Large excision is necessary for adenomyoepitheliomas because of the risk of recurrence and, more uncommonly, their proclivity to metastasis. We report the case of breast myoepithelioma in a 42 years old woman. The tumor was clinically, radiologically and macroscopically well demarcated. Histologically the tumor was composed of myoepithelial cells with few cellular atypias and a low mitotic activity. Tumor cells expressed vimentin, actin, S100 protein and cytokeratin. This particular immunohistochemical phenotype allows the differential diagnosis with other breast tumors.

Adult↗
PubMed1995

[Ovarian hydatic cyst. 7 cases].

Seven cases with echinococcal infection of the ovary, including 3 on both sides, were collected at the Salah Azaiz Institute of Tunis during a period of 23 years. This localisation is rare, even in an endemic country. The aetiology and pathogenesis of this affection may give rise to many different clinical signs, problems with pre-operative diagnosis. It is important to follow up these cases after operation in order to sport recurrences. The objective of surgical treatment is to achieve cure of both the hydatic cyst of the ovary and the primitive cyst simultaneously. Following this treatment, two difficulties may arise: the first one is preoperative rupture of the cyst; the second concerns fertility in these young women after two-sided salpingo-oophorectomy. Finally, when a pelvic cyst is observed systematic hydatic serology must be performed.

Adult↗
PubMed1995

[Breast angiosarcoma. Five case reports].

The authors report 5 cases of breast angiosarcoma collected in the Salah Azaiz Institute of Tunis, the only oncology center in this country, between 1969 and 1990. They enumerated 4,000 malignant breast tumors during this period; i.e. an incidence of 1.25%, higher than that in the world literature (0.4%). The mean age of patients was 44. Three were post-menopausal, and two were of childbearing age, one of whom was pregnant. This rare tumor is virtually limited to women. Affection is scarce, it affect's almost exclusively women. It generally present as a painless, ill-defined mass, without regional lymphadenopathy. The diagnosis of angiosarcoma is difficult since the histologic appearance is sometimes identical to that of a hemangioma. Hence the value of very thorough histologic examination of the entire operative specimen. Treatment is based upon mastectomy. The usefulness of adjuvant chemotherapy and/or radiotherapy is uncertain. The prognosis remains gloomy despite early diagnosis and treatment. The authors attempt in this study to identify the various features of this serious and uncommon condition, based upon the rare published cases in the world literature.

Adult↗
PubMed1994

[Granular cell tumors of the breast. Apropos of two cases].

Granular cell tumors of the breast are rare. The clinical presentation, the poor macroscopical delimitation and the infiltrating appearance of the tumor cells between the mammary lobules and within the adipose tissue may lead to a diagnosis of carcinoma, especially on frozen section. The authors present two cases of granular cell tumor of the breast occurring in two women aged 19 and 59 respectively. Before surgery, the diagnosis was that of a malignant tumor. In both cases, frozen section suggested the diagnosis of a granular cell tumor, which was confirmed by immunohistochemical study in one patient.

Adult↗
PubMed1994

[Tumoral calcinosis: a clinical and pathological study of 8 cases reported in Tunisia].

Tumoral calcinosis is a distinct clinicopathological entity characterized by periarticular soft-tissue calcium deposits. It is a rare condition in Tunisia (8 cases during 23 years). Six patients were aged 14 years or younger. There was male predominance (SR: 7/1). Lesions were located about the hip in five patients and the elbow in three patients. Multiple localisations occurred in two patients. Histologically, all cases exhibited active phase of the disease. In our patients lesions were only surgically excised.

Calcinosis↗
PubMed1994

[Synovial sarcoma. Anatomoclinical aspects apropos of 8 cases].

Synovialosarcoma is a rare tumor, of difficult diagnosis. Authors report 8 cases diagnosed in the two pathology departments of Salah Azaïz Institute and the Universitary Hospital of Sfax, from 1985 to 1991. This tumor represents 2.96% of all soft tissues sarcomas treated in Salah Azaïz Institute. It occurs in young adults (the average age in our series: 28.8 years) with a male predominance (6 out of 8 cases), localized preferentially in the lower extremity. In the histological study, immunohistochemistry provides a great contribution in the diagnosis and classification of these tumors. The histoprognosis grading of Trojani applied to our cases shows the good correlation between the grade and the prognosis. Treatment is primarily surgical, consisting in wide excision to avoid recurrences that are unfortunately very frequent. Radiotherapy and chemotherapy give very inconstant results. Some authors recommend radiotherapy to sterilize the tumor field, and chemotherapy to prevent metastasis. The clinical course is characterized by a high frequency of local recurrences and pulmonary metastases.

Adolescent↗