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Biomedical subjects

R Kiessig

Publications and source records attributed to R Kiessig.

17 recordsLinked to original sources

Levels of vasopressin and oxytocin in neurohypophysis and plasma of the postnatally developing rat and the influence of hypothyroidism on rat fetuses.

Arginine vasopressin (AVP) and oxytocin (OXT) were measured simultaneously by radioimmunoassay in neurohypophyses of rats immediately before birth (fetal day 22) onward to day 50 of life. The neurohypophysial content of AVP exceeded that of OXT by factor 17 at fetal day 22, by 20 immediately post natum, and by 2 at day 21 of life, respectively. As compared to day 0, the content at day 21 is considerably higher (AVP 24 fold, OXT 270 fold). The poor correlation between neurohypophysial AVP and OXT content suggests the possibility of a different onto-genetic development of both neuropeptide systems. Both AVP and OXT were detected in pooled rat plasma at various postnatal stages. Hypo- and hyperthyroidism induced experimentally during gestation did not result in a significant change in neuropeptide content of fetal neural lobes.

Age Factors↗

Experimental hypo/hyperthyroidism in rats and the perinatal development of the hypothalamo-neurohypophysial system in comparison with the thyroid gland state and external features.

Neurophysin was detected immunohistochemically in the hypothalamo-neurohypophysial system of Wistar rats not before fetal day 18. Formerly, neurophysin was identified on day 16 of intrauterine life using another breeding stock of Wistar rats, but the same immunohistochemical reagents. In pregnant rats, experimentally induced hypo/hyperthyroidism beginning with day 13 of gestation failed to show any evident influence on the first appearance of immunohistochemically detectable neurophysin during the fetal development. Otherwise, significant effects on fetal body growth and other external features as well as the fetal thyroid state and histochemically demonstrable thyroid peroxidase activity were shown. The influence of thiamazol on the fetal thyroid peroxidase points out a primary effect and indicates the permeability of the placenta to this antithyroid drug.

Animals↗

["Antibiotic hierarchy" oriented antibacterial chemotherapy in urinary tract infections].

The resistance of 708 germs isolated from 656 samples of ambulatory urological and gynecological origin was determined. The sensitivity of E. coli, proteus types and Pseudomonas aeruginosa to internationally used antibiotics was registered in detail as percentages. On the basis of the frequency of the germs and their resistence, an antibiotic "hierarchy" is drawn up, which can simplify the initial choice of therapy, especially in out-patient treatment.

Anti-Bacterial Agents↗

[A simple micro-procedure in virological and serological diagnosis].

The author reports on a micro-neutralization test which makes it possible to detect the antibodies against 7 different respiratory viruses (adeno and parainfluenza viruses) using only 0.080 ml of serum from patient. Swaged PVC foil used for packing pharmaceuticals, also known here as strip packing or press-through packing for pills and dragees was employed as plates for the cultures. This material is not toxic for the cell cultures, it is cheap and suitable also for other microbiological work in the field of serology.

Adenoviridae↗