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Biomedical subjects

R Kitagawa

Publications and source records attributed to R Kitagawa.

At least 55 records · Page 3Linked to original sources
PubMed1987

Effects of sodium citrate, potassium citrate, and citric acid in preventing experimental calcium oxalate urolithiasis in rats.

Male Wistar-strain rats which had been fed a glycolic-acid diet developed severe nephrocalcinosis with urinary calculi within 4 weeks. Rats fed the same diet with citrate salts added had, however, either slight or no nephrocalcinosis without any stones in the urinary system. Nephrocalcinosis intermediate between those in the citrate groups and the glycolic-acid group, with some urinary calculi, was observed in the citric-acid group. During the experiment, the urinary oxalate concentration increased markedly and was higher in the citrate and citric-acid than in the glycolic-acid group. The urinary citrate concentration was significantly higher in the citrate groups and lower in the citric acid and glycolic-acid groups. Therefore, citrate salts can be concluded to inhibit nephrocalcinosis and calculi formation as a result of decreased urinary saturation by means of increase in urinary citrate, in spite of a slight increase in the urinary oxalate.

Animals↗
PubMed1987

[Report of two cases of advanced renal cell carcinoma and our experience at Mito Saiseikai General Hospital].

A tumor thrombus in the vena cava (infrahepatic) was identified in a 70-year-old male with chronic obstructive lung disease, and right nephrectomy and thrombectomy were performed successfully. Therefore, he enjoyed good health for 6 months until he developed bone metastasis in the vertebrae and upper gastrointestinal bleeding. In another case of a 51-year-old male who presented with a mass in the posterior part of the chest; the biopsy specimen of the mass was reported to at least resemble renal-cell carcinoma. Subsequently, he underwent right nephrectomy and thoracotomy to remove the mass. He has since led an uneventful life without tumor recurrence. In our hospital from 1971 to 1980, 9 cases of renal-cell carcinoma have been experienced, including the above 2 cases. Their average age was 49.4 years, with ages ranging from 34 to 70 years. Seven patients presented with gross hematuria, and 2 patients, with flank pain. All 9 cases, all of whom underwent radical nephrectomy, were diagnosed pathologically as having renal cell carcinoma. The right side was involved in 3 cases, and the left, in 6 cases. The upper pole of the kidney was involved in 2 cases the middle in 1 case, and the lower in 5 cases. The mean 5-year survival rate was 69.2% and was closely associated with the tumor stage.

Adult↗
PubMed1987

[Evaluation of the enzymatic method using oxalate oxidase for urinary oxalate assay].

The principle of this kit method is that urinary oxalate is extracted and subsequently assayed by measuring the amount of hydrogen peroxide produced in an oxidation reaction catalyzed by oxalate oxidase. The reproducibility and accuracy of the method were tested: the within-run and day-to-day coefficients of variation were 5.4-20.0% and 16.1-18.0%, respectively, and the overall recovery rate of the added oxalate (5-25 mg/l) was 40-50%. These abnormally low recovery rates may be related to the presence of sulfate and phosphate in the extracted fluid. Therefore, the above method was modified by performing a recovery test by adding 25 mg/l oxalate to all urine samples. By the modified method, the correlation coefficient obtained between this method and the ion-chromatographic method was 0.851 (p less than 0.01). Urinary pretreatment with either acid ferric chloride or EDTA yields a higher recovery than with HCl. However, a good correlation of oxalate values is consistently observed for HCl-processed urine as measured by the above two methods. If the interference of ascorbic acid is negligible, no special urinary treatment except for HCl is necessary. The 24-hour urinary oxalate excretions were 24.4 +/- 9.1 mg (mean +/- SD) in 8 healthy males and 19.9 +/- 10.3 mg in 24 calcium-stone formers (21 males and 3 females).

Adult↗
PubMed1986

[A case of intrascrotal lipoma in a child].

A 3-year and 5-month old boy presented with the chief complaint of painless swelling in the scrotum, which had been noticed since birth. Under the diagnosis of intrascrotal tumor, an operation was performed. As the testis and epididymis were intact, the tumor was removed. The pathological diagnosis of the resected tumor was a well-encapsulated benign lipoma.

Age Factors↗
PubMed1986

[Prostatic carcinoma with metastasis to the testicle: a case report].

A 63-year-old man was admitted with the complaints of macrohematuria, sense of residual urine and urinary frequency. Physical examination revealed an enlarged hard prostate and left scrotal mass. The pathological diagnosis of the needle biopsy specimen of the prostate showed undifferentiated adenocarcinoma. The patient underwent bilateral orchiectomy for hormone therapy of prostatic carcinoma and treatment of suspected left testicular tumor. The histology of testicular tumor revealed metastasis from carcinoma of the prostate. Metastasis of the testis from prostatic carcinoma is rare in spite of the high incidence of the primary tumor. Clinical findings on testicular metastasis from carcinoma of the prostate obtained in 62 cases reported in available literature are reviewed and discussed in detail.

Adenocarcinoma↗
PubMed1986

[Follow-up cytology in the management of urotheliomas].

Ninety-one patients with operation history for urotheliomas were followed-up by urinary cytology for 17.5 months on the average. Cytologically, fresh urine was examined every month and vesical irrigation fluid every three months. Cystoscopy was also performed every three months, IVP every six months, and biopsy was performed when carcinoma or dysplasia was suspected. As a result, cases were classified into four groups. Group 1: All cytological examination were negative. Group 2: Cytology was positive for two or three months after TUR-Bt during which period vesical instillation therapy of anti-cancer drugs was performed, but was negative after this period. Group 3: Positive and negative cytology were diagnosed irregularly. Group 4: All cytological examinations were positive. The numbers of cases classified into these groups were 27 (29.7%), 7 (7.7%), 43 (47.3%) and 14 (15.4%), respectively. Tumor recurrence was seen in 1/27 (3.7%), 0/7, 12/43 (27.9%) and 4/14 (28.6%) cases, respectively. Metastasis was seen in only five cases of the group 4. Tumor recurrence and positive urinary cytology at the same time were seen in nine cases (20.9%) of group 3, and eight cases (57.1%) of group 4. Thirty four cases (79.1%) with discrepancy of cytological and endoscopic findings in group 3, in which cases 20 cases had only positive irrigation cytology and 11 cases had positive fresh urine and irrigation specimens, were more suspicious of temporary existence of in situ carcinomas or dysplastic urothelium. Of six cases with the discrepancy in group 4, three cases were in situ carcinoma diagnosed by random biopsies, and four cases had positive cytologies after TUR-Bt continuously.(ABSTRACT TRUNCATED AT 250 WORDS)

Carcinoma in Situ↗
PubMed1986

[Renocolonic fistula complicated by a renal stone: report of two cases].

A renocolonic fistula, complicated by a renal stone, was diagnosed in two women, 53 and 63 years old. The first patient had had a previous history of surgery when she underwent exploratory laparotomy for a right perinephric abscess, but the attempt to remove the right kidney was abandoned due to complications and a drainage tube was left. Six years after the first admission, an increased purulent discharge brought her in for further evaluation, fistulography then disclosed the presence of a renocolonic fistula. The second patient had a staghorn stone in the non-functioning left kidney. Retrograde pyelography revealed a fistulous tract between the renal collecting system and the colon. Subsequently, both patients underwent surgery in one stage to remove the infected kidney and the involved colon. The postoperative course was uneventful in each case, and they have since led comfortable lives without any febrile episodes. These two cases are the 17th and 18th cases of renocolonic fistulas reported in the Japanese literature.

Colonic Diseases↗
PubMed1986

[Report of cases of adenomatoid tumors of the epididymis].

This is a report of two cases of adenomatoid tumor on the epididymis. Both patients presented with the chief complaint of an intrascrotal mass. One patient, 56 years old, had a tumor on the left epididymis and underwent left epididymectomy. The other patient, 65 years old, had a tumor on the right epididymis and underwent resection of the tumor. Subsequently histological diagnosis confirmed an adenomatoid tumor. From the Japanese literature, 103 cases of adenomatoid tumor including the present cases were reviewed. The tumor was located on the epididymis in 83 cases with a mean age of 39.6 years and on the testicular tunica in 11 cases with a mean age of 27.5 years. These tumors originated from two sites, from the serosal lining of the genital tract and from the Müllerian remnant. The former type is called by Yasuma the Mesotherial type and the latter, the adenomatoid type. The present two cases are of the adenomatoid type, which is usually found on the tail of the epididymis in men from 30 to 50 years of age.

Aged↗
PubMed1986

[Clinical study of renal pelvic tumors].

A retrospective study was conducted on 22 patients with renal pelvic tumor treated at our University Hospital between 1970 and 1984. The patients included 18 males and 4 females, from 31 to 81 years of age. The left kidney was involved in 14 cases, and the right in 8. More than 60% of them also presented gross hematuria. IVP abnormalities included filling defects in 9 cases and non-visualizing kidney in 8 cases. Pretreatment urinary cytology was positive in 65.7%. Radical nephroureterectomy was performed in 18 cases, followed by adjuvant therapy in 10 cases; radiation in 5 cases, chemotherapy in 4 cases, and radiation/chemotherapy in one case. Histology revealed transitional cell carcinoma in all cases. On diagnosis, simultaneous urothelial tumors were identified in one case in the ureter and the bladder, and in one case in the bladder. Tumor development after surgery was observed in 9 cases, 8 in the bladder and one in the ipsilateral renal pelvis. The 5-year actual survival rate was 58.2% over all: that of the low-grade group was 100%; that of the high-grade group, 45.1%; that of the low-stage group, 100%; that of the high-stage group, 19%. In conclusion, the prognosis in our series was significantly influenced by the stage and grade of the tumor.

Adult↗
PubMed1986

[Transitional cell carcinoma developed in association with renal stone and ureter catheter: report of two cases].

Chronic irritation or infection may cause a neoplastic change in the uroepithelium. Our recent experience with two cases of transitional cell carcinoma associated with such stimuli is reported. A 58-year-old woman was found to have a staghorn stone in the left kidney and underwent nephrectomy because of an atrophic kidney. Transitional cell carcinoma was incidentally identified microscopically on the renal pelvis of the removed kidney. Subsequently surgery was elected to remove the residual ureter and the retroperitoneal lymph nodes, both of which turned out to be non-malignant. Then, she was treated by combination chemotherapy with CTX, ADR and CDDP. The second case was a 77-year-old woman who had had a 15-year history of an indwelling ureter catheter after gynecological surgery. Because of purulent discharge without any urine production, she underwent nephrectomy for a contracted kidney. Histology revealed transitional cell carcinoma on the pelviureteral junction. The postoperative courses were uneventful in both cases: they were followed up for 6 months and 9 months respectively without any recurrence of the disease. 90 cases of renal pelvic tumors associated with renal stones were collected from the Japanese literature and reviewed.

Adult↗
PubMed1986

[The clinical effects of Tsumura No. 111 Seishin-rensi-in on irregular complaints of the urinary tract].

We studied the effects of Tsumura No. 111. Seisin-rensi-in on irregular complaints accompanying urological and renal diseases. Of 105 patients who visited our medical facilities, 99 served as the subject of this study. In principle, Tsumura Seisin-rensi-in was administered at a dose of 2.5 g x 3 times/day before meals for 4 or more weeks. Of 99 cases, 8 showed excellent results (8.2%), and 42 showed positive effects (41.2%). Adverse effects were observed in 7 cases, and in 4 cases drug administration was discontinued. This drug was recognized to be effective against irregular complaints accompanying chronic cystitis and acute or chronic pyelonephritis.

Cystitis↗
PubMed1985

Large renal hemangioma necessitating nephrectomy.

An unusually large renal hemangioma with nonfunction on an excretory urogram is reported. Preoperative angiography revealed typical early draining veins in the kidney. Contrary to the previously reported cases preoperative angiography precluded renal salvage procedure. The resected kidney was nearly completely replaced with cavernous hemangioma. To the best of our knowledge this is the largest renal hemangioma on record.

Aged↗
PubMed1985

Primary hyperparathyroidism. Case report and management.

A 13-year-old girl presenting with abdominal pain, polyuria, polydipsia, and radiologically confirmed renal calculi was diagnosed as having primary hyperparathyroidism. Laboratory data revealed markedly elevated serum calcium, low phosphorus, and elevated parathyroid hormone. Other parathyroid function tests also confirmed the diagnosis of primary hyperparathyroidism. Ultrasound examination showed a small echogenic nodule in the parathyroid gland. Following a single gland resection, the extremely high serum calcium level promptly decreased to normal range, and it has remained normal.

Adolescent↗
PubMed1985

[Statistical study of outpatients with hematuria].

The records of 2,545 outpatients who visited our clinic from January, 1983 to September, 1984, were reviewed retrospectively. Gross hematuria was recognized during the clinical course in 341 patients, and microscopic hematuria, in 873 patients. The patients who experienced hematuria included 701 males and 513 females. The most common causes of hematuria were UTIs (53.0%), urinary tract calculi (15.6%), and malignant tumors (7.1%). Patients with malignancies tended to develop gross hematuria rather than microscopic hematuria; moreover gross hematuria caused by a malignancy was seen more commonly in the elderly population. In renal parenchymal diseases (e.g. glomerulonephritis and IgA nephropathy), continuous hematuria (93.7%) was the rule, although in calculous diseases (55.9%) and prostate hypertrophy (73.9%), intermittent hematuria was more frequent. Hematuria caused by G-U malignancy could not be specified as either microscopic or gross or as either continuous or intermittent. In conclusion, hematuria is a sign of malignancy in 7.1% of all outpatients with hematuria during the clinical course; therefore, a complete examination is indicated for any kind of hematuria.

Adolescent↗