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Biomedical subjects

R Klimek

Publications and source records attributed to R Klimek.

At least 19 recordsLinked to original sources
PubMed1992

Biological gestational age and its calendar assessment with ultrasound. Part 1: Physiological considerations.

Biological gestational age differs from calendar age, which is only its measurement. In spite of that in many countries all over the world, the rule for termination of pregnancy exclusively because its calendar duration is longer than 293 days (so-called postterm pregnancy) is widely applied. Constant increase in the blood oxytocinase level of pregnant women, just like the sonographic measurements of fetal bodies, proves the appropriate development of pregnancy with all the more accuracy, the more similar the subsequent values of the enzymatic and ultrasonographic determinations. From medical and ethical points of view the 'obstetrical' scale comprising sequential periods' pre-, at- and post-term' is an incorrect way of calculating the duration of pregnancy. Gynecologists have to use the word 'term' only to describe an individual's date of fetal maturity (birth-date) and the possible true pre- and post-term of an individual should be placed within as well as outside the normal range of deliveries.

Birth Weight↗
PubMed1992

Biological gestational age and its calendar assessment with ultrasound. Part 2: Biological-calendar scales for prediction of birth-date.

Evaluation of enzymatic and sonographic assessments has been done in terms of relativity of gestational length. The principle of relativity means that it is not the calendar time but the biological one that qualifies the results of both the diagnostic procedures and treatments. The described biological-calendar scale comprises and links both the enzymatic and ultrasonographic data. The shifting of the end of the biological scale to the end of the calendar scale enables the appropriate evaluation of both the child's maturation for labor, as well as the pregnancy duration from the last menstrual period until the end of normal births range. It is why almost all ultrasound scales heretofore useful only for 50% of deliveries (as usually encompassing range of 40 weeks) have to be lengthened.

Cystinyl Aminopeptidase↗
PubMed1992

[Role of gynecology in etiopathogenesis of cervical carcinoma].

Cancer as a natural stochastic phenomenon and disease can be promoted by many non-specific factors, including also such gynecological ones as: 1. faulty prediction and determination of birth date: 2. instrumental instead of possible natural labor; 3. reduction rather prolongation of lactation; 4. acceptation of early sexual life; 5. wrong hormonal therapy; 6. longlasting prescription of pills; 7. infrequent diagnosis and wrong therapy of hypothalamic conditioned abortions and premature deliveries; 8. clinical, colposcopic and cytologic false negative diagnosis of cervical cancer; 9. eradication of neoplastic lesion without normalization of environment, and 10, too radical and aggressive treatment of precancerous states. Medicine as no other field of human activity requires from the gynecologists the specific responsibility for conscientious constant acquisition of general knowledge to ensure the future of human species especially in conquering "cancer of mothers" and preventing "cancer of early sexual life".

Female↗
PubMed1990

Nuclear magnetic resonance in obstetrics and gynecology.

The modern gynecologist has access to real time nuclear magnetic resonance (NMR) images. This approach leads to an appreciation of the structure and function of an organ at the atomic level. The combination of NMR imaging and spectroscopy leads to images of female pelvic organs whose appearance is dependent not only on the reproductive and hormonal status of these structures, but also on the physical specifications of the scanner, the main magnetic field and the radiofrequency pulses as well as the time elapsed between them. The basis of gynecological diagnosis is at its optimum with NMR local coils in a time of only 20-25 ms with a resolution and penetration depth that has never before been achieved. Many obstetric and gynecologic investigations are best interpreted by a gynecologist's personal experience with USG, CT or angio-, veno- and lymphography. Such an individual can best evaluate NMR findings with three-dimensional pictures, in real-time, of fetal heart beat, on the one hand, to tumor staging on the other.

Female↗
PubMed1990

Cervical cancer as a natural phenomenon.

Recognizing cervical cancer as a natural stochastic phenomenon, that is in the first stage of its self-organization into a new biological dissipative structure (initiation) and sustaining its development in the second stage (promotion), is a basic requirement in conquering cancer and preventing neoplastic disease, i.e., the third stage of neogenesis (progression). A dissipathogenic state inside an organism is the only common primary cause of neoplasia. Thus, medical thermodynamics clarifies why so many non-specific factors enable the origin of cervical cancer, that is, can cause cervical dissipathogenic states. This thermodynamical theory abolishes opposition and unites the heretofore cellular neoplastic theories by bringing them to an atomic level. Diagnosis and treatment of dissipathogenic processes implies true causal prophylaxis of cancer, therapy of which always has to encompass its environment.

Female↗
PubMed1989

Effect of immunopotentialization on rate of vaginal smear normalization according to appearance of cervical intraepithelial neoplasia.

Sixty one women (age range 20-35 years) treated by Gynatren-immunopotentialization (three vaccinations every second week) were divided into two groups: group I with cervical intraepithelial neoplasia (CIN) and group II without CIN. Four weeks of therapy resulted in normalization of the vaginal flora and cervical milieu as well as in disappearance of CIN in 54% of cases stated cytologically. These findings confirmed our previous observations. Moreover, it was stated that process of regression of inflammation, metaplasia as well as normalization of vaginal flora is less apparent in women with CIN.

Adult↗
PubMed1989

Test of immunopotentialization in colposcopy--a clinical evaluation.

52 infertile women (age range 19-35 years) treated by Gynatren-immunopotentialization (three vaccinations every second week) were divided into two groups according to appearance of cervical intraepithelial neoplasia (CIN). 30 women had CIN cytologically diagnosed and proved by colposcopy (group II). Colposcopic examinations were performed on the first day of therapy (first vaccination), after two weeks (second vaccination) and after four weeks (the day of the third injection). Four weeks of the therapy resulted in normalization of cervical milieu (e.g., complete regression of infection in 68.2% of I group and 56% of II group) as well as in disappearance of CIN in 66% of cases and in remaining ones there was a 7-times decrease of CIN II. It was colposcopically stated that the process of statistical significant regression of inflammation as well as normalization of cervical pathology is less apparent in women with CIN. These findings confirmed our previous cytological observations.

Adjuvants, Immunologic↗
PubMed1989

[Therapy of neoplasms as self-organizing dissipative structures].

The lack of possibilities of forecasting the effectiveness of methods and procedures applied in particular cases of neoplasms and the effectiveness of different methods in similar stages of a disease progression, the latter not being understandable so far--can be easily explained thermodynamically. The results of there procedures is statistically conditioned and depends solely on the state of equilibrium between the host and the neoplasm. One can expect to be effective only such methods which strengthen or complement the adaptive-reconstructive-protective ability of a human organism, weakening at the same time or destroying the inner state of a neoplasm. Also in case of neoplasms, the most difficult to accept are the methods being ahead not as much of human knowledge as of the knowledge of medical practitioners.

Adaptation, Physiological↗
PubMed1989

[Diagnosis and therapy of neoplasms as seen by atomic pathology].

The structure and function of an organism are only the two aspects of the same reality. Totally identical tissue pictures which we find under a microscope can also be obtained directly from the inside of an organism by the use of magnetic resonance (nmr) of atoms making up these tissues. The histopathological picture shows the structure in vitro only whereas an nmr picture shows it in vivo, in addition to the function as the atoms making it up are in constant motion changing their behaviour depending on the state of the environment. Thus this technique can be used to examine both the structure of organs with the flow of fluids in them and the concentration of components of their metabolism. Medical thermodynamics generalizes and unifies at the same time the world of atoms with psychic and emotional life of a man. Based on cellular pathology, three (used independently or together) classical treatment procedures, surgery, irradiation and chemotherapy, are only symptomatic treatment, not casual treatment. Each of them may, however, modify the neural, hormonal and immunological activity of an organism. In the view of more and more evident identity on the molecular level of these morphologically isolated systems, hormonotherapy and immunotherapy have finally come into use. Since neoplasms are a natural phenomenon, this requires from people, and not only doctors--a radical change of opinion on their nature, thusit requires directing intellectual and material activity towards also natural protection against them. Historical experience shows that neoplasms cause a complete specific, different from all others, kind of diseases. That is why also therapy must be different, based on atomic pathology and consistent with laws of Nature.

Humans↗