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Biomedical subjects

R Klug

Publications and source records attributed to R Klug.

6 recordsLinked to original sources

The clinical utility of visual-evoked potential acuity testing.

We assessed the clinical utility of objectively measured acuity using visual-evoked potentials. The technique was first standardized in normal emmetropic subjects and then applied to uncorrected myopic subjects. We found that visual-evoked potential acuity could accurately indicate Snellen acuity in emmetropia and corrected myopia; however, the two measures were highly correlated only in those uncorrected myopic subjects with visual acuities of 20/100 or better. In subjects with poorer than 20/200 uncorrected visual acuity caused by myopia, estimates of visual-evoked potential acuity could not be obtained. The correlation between these two measures of visual acuity was also lower in patients with decreased Snellen acuity attributable to retinal or ocular disease. We found that patients with unexplainable claims of decreased visual acuity could be diagnosed as having functional visual loss based on objective visual-evoked potential acuities.

Adolescent

Pseudomyxoma peritonei.

In pseudomyxoma peritonei, mucinous implants develop on peritoneal surfaces and omentum, often resulting in gelatinous ascites. Definitive treatment has not been established. Adjunctive radiation therapy or chemotherapy following laparotomy has improved survival in some patients.

Adult

The effect of prostaglandin on iridial blood vessel permeability.

Light and electron microscopy is used to examine the effect of exogenous PGE1 on the permeability and reactivity of rat iridial blood vessels. Results show that topical PGE1 causes an increase in the permeability of iridial vessles to carbon particles (200 A diameter). The technique of carbon labelling is used to quantitate increases in permeability caused by varying concentrations of PGE1 (0.001-1.0 mg/ml). Regression analysis shows that there is a linear relationship (P less than 0.02) between carbon labelling and PGE1 concentration over the range of concentrations tested. In other experiments rats were treated with the systemic histamine liberator Compound 48/80, or with topical applications of histamine diphosphate in order to examine the effects of exogenous and endogenous histamine upon iridial blood vessel permeability. These procedures produce only minimal labelling of iridial vessels. It therefore seems likely that PGE1 has a direct effect on iridial vessels and does not act indirectly by bringing about the liberation of endogenous histamine.

Administration, Topical