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Biomedical subjects

R Korte

Publications and source records attributed to R Korte.

49 records · Page 3Linked to original sources
PubMed1975

Protein versus energy in Papua New Guinea.

Protein deficiency has in the past generally been considered the main nutritional problem in the world. This has unduly detracted attention from the need for an adequate energy intake. Using surveys from different areas in Papua New Guinea, it is shown that deteiled investigations are needed to determine actual nutritional needs. In the Sepik a severe energy deficiency was found to be the principal problem. In some Highland areas, on the other hand, a distinct protein deficiency was observed, compounded by a low energy intake in the under 5-years age group. These distinct dietary patterns require a vastly different approach to nutrition intervention. It is shown that nutritional needs in the Sepik could in principle be met by increasing the availability of staple foods. An emphasis on protein would be a misdirected effort for most areas there. In the Highlands emphasis should be placed on legumes particularly those with a high energy value. This could close the protein gap and help to meet the caloric needs of young children.

Adolescent↗
PubMedDate not supplied

Resistance in vivo of Plasmodium falciparum to co-trimoxazole in western Uganda.

In the context of the 'integrated management of childhood illnesses' (IMCI) programme the World Health Organization recommends treating children in malarious areas presenting with fever and respiratory symptoms with co-trimoxazole. In order to verify its effectiveness in uncomplicated Plasmodium falciparum malaria we carried out a study in vivo in western Uganda: 180 children under 5 years old were enrolled and treated with 40/8 mg/kg/d co-trimoxazole over 5 d, and 159 could be followed on days 3, 7 and 14. Effectiveness of treatment was found to be significantly different in various parts of the study area. In Bundibugyo District, bordering République Democratique du Congo (Zaire), 59.1% (39/66) of children were clinically cured after 14 d and 56.1% were parasitologically cured. In the east of Kabarole District (43 children), the figures were 76.7% and 65.1%, respectively. In western Kabarole (50 children) the rates were 96.0% and 90.0%, respectively. We conclude that, in view of the high level of clinical failures in parts of the study area, co-trimoxazole should not be used in the IMCI programme for combined treatment of malaria and pneumonia in the region. Assessment of therapeutic effectiveness of antimalarial drugs needs to consider the microepidemiology of resistance.

Antimalarials↗
PubMedDate not supplied

Pattern of sexually transmitted diseases in a Malagasy population.

BACKGROUND: Data concerning the spectrum and antimicrobial susceptibility of STDs in Madagascar are scarce. OBJECTIVES: Improvement of STD patient management in Madagascar. GOAL OF THE STUDY: Assessment of the spectrum of STDs and improvement of therapy. STUDY DESIGN: Etiologic study of 400 patients (169 men, 231 women) under consultation at the major STD service in Antananarivo for one or more of the STD syndromes, urethral discharge, cervicovaginal discharge, genital ulcers, or condylomata according to a fixed diagnostic schedule. RESULTS: Of genital ulcers, syphilis accounted for 46%, lymphogranuloma venereum for 24%, chancroid for 16%, and herpes for 1%. Of the syphilis cases, 51% presented as condyloma lata. Discharge was found in 124 men and 210 women. Counting concomitant infections separately, gonorrhea occurred in 69% of the men and 20% of the women with discharges, chlamydia infection in 42% and 52%, trichomoniasis in 9% and 31%, candidiasis in 12% and 30%. Bacterial vaginosis was found in 37% of the women with discharges. In 32% of male and 71% of female gonorrhea cases, there was concurrent chlamydia infection. Infection with HIV 1 or 2 was not detected. Determination of the antibiotic susceptibility of Neisseria gonorrhoea revealed high efficacy of ampicillin, ciprofloxacin, and spectinomycin; but frequent resistance to tetracycline and cotrimoxazole. CONCLUSIONS: High priority should be given to the management of infections with chlamydia and with Treponema pallidum as well as to educational measures to increase awareness of genital ulcer disease.

Adolescent↗