[Compartment analysis of Ca turnover in the isolated guinea pig heart].
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Animals↗
Biomedical subjects
R Krebs
Publications and source records attributed to R Krebs.
[Dissociation of function and metabolism of the isolated guinea pig heart under the influence of phosphodiesterase inhibitors].
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Animals↗
[Cellular bases of the positive inotropic effect of cardiac glycosides, catecholamines and methylxanthines].
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Calcium↗
[Clinical experiences with Theo-Caradrin in cardiac insufficiency].
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Adult↗
[Strophanthin action on myocardial oxygen consumption in dependence upon the functional capacity of the heart].
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Animals↗
[Effect of phosphodiesterase inhibitors on the heart].
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Animals↗
[In vitro studies on the effect of digitoxin on the uptake of calcium in lipoid extracts from heart muscle].
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Animals↗
Increase in suicidal thoughts and tendencies. Association with diazepam therapy.
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Adult↗
[Effect of digitoxigenin and ouabain on mechanical activity and oxygen consumption of isolated heart muscle preparations].
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Animals↗
[An improved method for simultaneous measurement of oxygen consumption and mechanical activity of isolated muscle preparations].
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Animals↗
[On the effect of strophanthin on myocardial O2 consumption as a function of the initial state].
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Animals↗
[The nurse anesthetist in the surgical team].
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Anesthesiology↗
Treatment of hepatic coma with exchange transfusion and peritoneal dialysis.
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Adolescent↗
Adverse reactions with calcium antagonists.
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Adrenergic beta-Antagonists↗
Clotrimazole as an inhibitor of benzo[a]pyrene metabolite-DNA adduct formation in vitro and of microsomal mono-oxygenase activity.
The fungistatic drug clotrimazole (1-[(o-chlorophenyl)diphenylmethyl]imidazole) in concentrations of 5 or 50 microM completely prevented the formation of benzo[a]pyrene metabolite-DNA adducts in vitro catalyzed by liver microsomes from phenobarbital-or 3-methylcholanthrene-treated rats, respectively. Microsomal 7-ethoxycoumarin de-ethylase and aryl hydrocarbon hydroxylase were effectively inhibited by clotrimazole and three clotrimazole derivatives in all induction states tested, with I50 values down to 7 x 10(-8) M. The mechanism of inhibition was noncompetitive in phenobarbital-stimulated microsomes. Microsomal epoxide hydratase in vitro was enhanced up to 450% by clotrimazole and one of the analogues in concentrations between 5 and 500 microM. Clotrimazole spectrally interacted with reduced cytochrome P-450, exhibiting a double-banded Soret region with peaks at 427 and 446 nm, and partially prevented cytochrome P-450-CO complex formation. When administered in vivo, clotrimazole effectively induced cytochrome P-450 content, mono-oxygenase activity and epoxide hydratase activity in rat liver microsomes. The induction pattern was similar to that obtained with phenobarbital. The analogues were less potent inducers.
Animals↗