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Biomedical subjects

R Kuffer

Publications and source records attributed to R Kuffer.

At least 55 records · Page 3Linked to original sources
PubMed1979

[Cowden's disease. A report on two cases in Swiss families (author's transl)].

Described by Lloyd and Dennis in 1963, Cowden's disease is a familial affection in which are found associated lesions of the buccopharyngeal mucosa (papillomatosis, papules, scrotal tongue), various types of skin lesions (verruciform keratotic papules, papilloma, lipoma, angioma, etc...), visceral manifestations usually related to lesions in the thyroid, breasts, or digestive tract (hamartoma or malignant tumors), and skeletal dysmorphism. The two patients were from different families, were aged 65 and 28 years, and had presented for consultation because of buccal mucous membrane papillomatosis, and in one case, hemorrhagic gingivitis. Cowden's disease was diagnosed from the clinical examination, past history, and investigations after hospital admission. The main value of the mucosal and cutaneous lesions is their diagnostic significance, enabling a synthesis of the multiple dispersed manifestations to be made, and a possible visceral tumor to be discovered in the early stages.

Adult↗
PubMed1979

[Stomatodynias].

Stomatodynies are functional manifestations often observed in anxious and depressive individuals, in the form of glosso-, cheilo-, uranodynia. It may show itself in disturbances of the mucosa or of salivary secretion. It is necessary to reassure the patients, to explain the nature of the disease and to prevent them from autotherapy of local or psychic factors.

Diagnosis, Differential↗
PubMed1979

[Cowden disease: report of 8 cases in 2 families (author's transl)].

These 8 cases of multiple hamartoma syndrome are the first reported in Switzerland. Two men aged respectively of 65 and 28 years presented a cobblestone appearance of the gingiva and of the tongue ("pebbly tongue"), which suggested Cowden disease. This diagnosis was confirmed by the discovery of numberous skin lesions, a thyroid goiter, gastrointestinal polyposis, and a mild skelettal dysmorphosis. The older patient had a grade one carcinoma of the bladder; his son and his daughter presented the syndrome, which was also discovered in the family of the second patient (his father, his brother, his sister and one of her daughters). The ultrastructural study of two skin biopsies demonstrated anomalies of the fibroblasts and collagen fibers.

Adolescent↗
PubMed1977

[The contractile filament system of carcinoma cells. Immunofluorescent and electron microscopic study].

Recent research has shown that the cytoplasm of several varieties of non muscular cells contains contractile proteins similar to those of striated muscle (actin and myosin, with the control complex of troponin and tropomyosin). Using indirect immunofluorescent staining with specific antisera, the authors demonstrate that the cytoplasm of the cells of oral squamous cell carcinoma contains actin, myosin and actinin (tropomyosin seems to be lacking). They have found these contractile proteins inconstantly in various precarcinomatous states, but never in normal epithelium, except in a few basal cells. In electronic microscopy, these contractile proteins correspond to a network of microfilaments of 40-80 A, more rarely 100-120 A, Clearly different from tonofilaments, located mainly in the peripheral part of the cytoplasm, just under the plasmalemmal membrane. It is tempting to speculate that the occurence of a contractile filamentous apparatus in the cells of oral carcinomas--already described in skin and mammal gland carcinomas--allows to these cells amoeboid movements and active migration, which might to some extent explain their tendency to invade surrounding tissues and to produce metastasis.

Actinin↗
PubMed1976

[Dominant generalized cortical hyperostosis with multiple involvement of the cranial nerves].

The authors report an observation of dominant generalized cortical hyperostosis with multiple and unilateral involvement of a certain number of cranial nerves. In other members of the family, who present with the same bone disorder, involvement of the cranial nerves was limited to the facial nerve, either uni or bilaterally, with a partially or totally regressive evolution. This cranial nerve involvement, which is classic in the recessive form (first described) of generalized cortical hyperostosis, has until now, never been reported in the dominant form of this disorder.

Adult↗
PubMed1975

[Odontogenic keratocysts].

Keratocysts may develop from cellular multiplication, from recidivating growth of epithelial cells left after curettage, and they have an important potential growth, they can degenerate into malignancies. There are several etiological possibilities: tissues connected with crown formation, invagination of nucous epithelium, degeneration of follicular cysts producing keratin. The most important characteristic of these cysts is the frequent recidivation. Fron a clinical standpoint, they are classified as benign tumors. After enucleation, the walls of healthy tissue should be reduced, particularly in locations where the access of curettes is difficult. If necessary, apicetomy is performed in order to completely eliminate the cyst walls. Histological examination is mandatory. Finally, radiologic controls during at least six years should be made.

Adult↗