What causes non-monotonic tuning of fMRI response to noisy images?
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Animals↗
Biomedical subjects
R L Achtman
Publications and source records attributed to R L Achtman.
The cortical deficit in humans with strabismic amblyopia.
To further our understanding of the cortical deficit in strabismic amblyopia, we measured, compared and mapped functional magnetic resonance imaging (fMRI) activation between the fixing and fellow amblyopic eyes of ten strabismic amblyopes. Of specific concern was whether the function of any visual area was spared in strabismic amblyopia, as recently suggested by both positron emission tomography (PET) and fMRI studies, and whether there was a close relationship between the fMRI response and known psychophysical deficits. To answer these questions we measured the psychophysical deficit in each subject and used stimuli whose relationship to the psychophysical deficit was known. We observed that stimuli that were well within the amblyopic passband did produce reduced fMRI activation, even in visual area V1. This suggests that V1 is anomalous in amblyopia. A similar level of reduction was observed in V2. In two subjects, we found that stimuli outside the amblyopic passband produced activation in visual area V3A. We did not find a close relationship between the fMRI response reduction in amblyopia and either of the known psychophysical deficits even though the fMRI response reduction in amblyopia did covary with stimulus spatial frequency.
Adolescent↗
Detection of constrast-defined shape.
We assessed the accuracy of contrast-defined shape detection of stimuli of constant aspect ratio, namely, circular bandpass stimuli whose radii were sinusoidally varied about a mean radius. Performance for these contrast-defined shapes, which we show is determined by the global rather than the local attributes of the stimulus, is 2-8 times worse than that for their luminance-defined counterparts, suggesting separate processing limitations. By spatially and orientationally filtering the two-dimensional fractal-noise carriers of which these stimuli were composed, we determined whether there are specific rules concerning the spatial and orientational input to shape detectors from mechanisms sensitive to the carrier structure. The results suggest that second-order circularity detectors receive mixed input from spatial-frequency-tuned and orientationally tuned cells.
Contrast Sensitivity↗
Regional sensitivity for shape discrimination.
In a task where subjects had to detect smooth deviations from circularity, we assessed whether performance varied with eccentricity. Our stimuli were circular 4th derivatives of Gaussian contours (CD4s) whose radii were sinusoidally modulated. We used D4s of different peak spatial frequencies and overall diameters. Although performance declined with eccentricity for all radial frequencies tested, once scaling was taken into account, sensitivity was similar at all eccentricities. This was the basis of the scale-invariance also exhibited by this task. Thus, shape discrimination does not appear to be a specialized function limited to central vision.
Form Perception↗