PubMed HealthSearch

Biomedical subjects

R L Applegate

Publications and source records attributed to R L Applegate.

3 recordsLinked to original sources

Persistent sacral nerve root deficits after continuous spinal anaesthesia.

Neurological deficits following spinal anaesthesia are rare. We report two cases of persistent sacral nerve root deficits after continuous spinal anaesthesia (CSA) performed with hyperbaric lidocaine through a lumbar microcatheter. In both cases the dose of 5% lidocaine (5.7 and 4.3 ml) was greater than usual. In the immediate postoperative period the constellation of neurological deficits included perianal hypaesthesia, lower extremity paresis, urinary retention, and difficult defaecation. Both patients have residual perianal hypaesthesia and difficult defaecation. In these cases, the high-dose requirements of local anaesthetic via microcatheter CSA with focal sensory block suggests nonuniform distribution of the hyperbaric lidocaine. Microcatheter CSA may convey a unique risk of maldistribution of the local anaesthetic solution and local neurotoxicity.

Aged

Factor analysis of the substance abuse attitude survey with college undergraduates.

Few standardized instruments measure attitudes and beliefs towards substance abuse. The Substance Abuse Attitude Survey, developed for measuring drug attitudes in medical education, was administered to 598 college undergraduates, and a factor analysis was performed. Three coherent and stable factors were identified, e.g., Stereotypes and Moralism, Treatment, and Permissiveness. Internal consistency and 6-wk. test-retest measures indicated moderate to high reliability factor structure. Results are discussed in terms of sample differences between this effort and a previous validation.

Adult