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R L Cabrini

Publications and source records attributed to R L Cabrini.

At least 73 records · Page 4Linked to original sources
PubMed1986

Alveolar wound healing after x-irradiation: a histologic, radiographic, and histometric study.

Healing of extraction wounds in rats following cephalic irradiation was studied by histologic, radiographic, and histometric methods 14 days after tooth extraction. Irradiation was given at 0, 3, and 7 days after surgery in doses of either 15, 20, or 30 Gy. No significant differences were seen with the different doses given seven days post-extraction. However, socket healing was delayed when irradiation was given immediately and three days after extraction. On the basis of these observations, it is recommended that radiation not begin until at least one week after the extraction of teeth.

Alveolar Process↗
PubMed1986

Effect of diphosphonate on the prevention of X-radiation-induced inhibition of bone formation in rats.

A histologic and histometric study of the effect of EHDP (ethane-1-hydroxy-1,1-diphosphonate) on the alveolar wound healing of irradiated animals is presented. This drug was selected based on its osteosclerotic effect when applied at low doses. The three left mandibular molars of 80 male Wistar rats were extracted. The rats were grouped into 4 sets of 20 rats each. Group I received no further treatment; Group II received daily intraperitoneal injections of EHDP (7.5 mg/Kg of body weight during 10 days); Group III: 15 Gy of X-radiation were applied to the head; and Group IV were irradiated and injected with EHDP as were animals of Groups III and II. Half of the animals were killed after 14 days and the other half 30 days post-extraction. Sections were made at the level of the mesial socket of the first molar in a bucco-lingual orientation, on which histometric determinations of bone activity were made. The results showed the attenuation of the inhibitory effect of radiation on bone formation when the animals were treated with EHDP.

Alveolar Process↗
PubMed1985

Alveolar wound healing and ridge remodeling after tooth extraction in the rat: a histologic, radiographic, and histometric study.

Healing of extraction wounds in rats was analyzed by histologic, radiographic and histometric methods at 0, 7, 14, 30, 60 days after tooth removal. Total alveolar volume, volume density of bone, percentage of bone formation, bone resorption areas, and height of both vestibular and lingual crests were analyzed. Total alveolar bone volume and bone density in the apical third increased from 0 to 60 days. Maximum bone formation was observed at 14 days, whereas the greatest bone resorption was observed seven days after extraction. The height of the lingual crest was lowest 14 days postextraction and then increased progressively to day 60.

Alveolar Process↗
PubMed1985

Alveolar wound healing alteration under uranyl nitrate intoxication.

The deposit of uranium compounds in calcifying zones has been demonstrated in bone. Nevertheless, no studies on the effect of uranium on osteogenesis have been performed. A histologic and histometric study of the effect of a single intraperitoneal injection of 2 mg/kg of body weight of uranyl nitrate on bone formation is presented. It was performed on rats' healing sockets, 14 days after tooth extraction. The alveolar bone volume (15 X 10(5) micron vs. 34 X 10(5) micron2), total bone formation areas (4.85% vs. 19.55%), and volume density of bone in the alveolar apical third (0.26 vs. 0.40) were significantly lower in intoxicated animals than in the controls. These results indicate the inhibitory effect of uranyl nitrate on bone formation.

Alveolar Process↗
PubMed1985

Scanning electron microscopy of human submandibular gland.

The fracture surface of human submandibular gland analyzed by scanning electron microscopy is studied here. Acini showed spherical granules of 0.7 +/- 0.28 micron diameter, their most distinctive feature. Some empty, septate cavities found contiguous to serous acini were considered to be mucous acini. Striated ducts had a circular lumen, with microvilli forming prominences. Blebs, some intact and others ruptured, were interpreted as apocrine secretion. The 'separating zone' of the striated cells was distinguishable from the rest of the cell because the structure of the cell was granular whereas the 'separating zone' was fibrillar.

Adult↗
PubMed1985

Changes in the vascular bed of submandibular glands after chronic autonomic denervation.

The effect of chronic sympathetic denervation (SCG) or parasympathetic decentralization (PSD) on the vascularization of the submaxillary gland (SM) of rat was studied in connection with morphological and functional changes. The resection of the superior cervical ganglion or the section of the chorda tympani was performed in adult male Wistar rats prior to the injection of Microfil MV Orange 3.25 cm3/kg. Once dissected, the glands were made transparent in increasing concentrations of methyl salicylate--alcohol. Three longitudinal sections were performed and the central one was projected in an automatic image analyzer (Kontron Zeiss), where vascular length and vascular volume were measured. Another group of animals was injected with Microfil after having received an injection of noradrenaline (10 g/kg) in SCG glands and methacholine in PSD glands. In SCG glands, vascular length underwent a 60% increase and the vascular volume increased from 0.26 +/- 0.15 cu mm/cu mm in controls to 0.54 +/- 0.15 cu mm/cu mm in SCG. The intravenous administration of noradrenaline prior to Microfil injection reverted the phenomenon. PSD caused a reduction of the vascular bed which resulted mainly in increased vascular volume. The administration of methacholine (10 g/kg) reverted the-response. It was concluded that SCG induced a loss of the existing vasoconstrictor tone, thus causing increase of vascular length and volume (passive vascular dilatation). Increased vascular volume after chronic PSD is compatible with vascular stasis and the absence of variations in vascular volume after the injection of methacholine would indicate that in the SM glands of rats there is no vascular dilatation tone.

Animals↗
PubMed1985

Virus-like intranuclear inclusions in giant cell tumor of bone.

An ultrastructural study of 13 cases of typical giant cell tumor of bone (GCT) revealed the presence of virus-like intranuclear inclusions (INI), morphologically identical to those reported in Paget's disease of bone. In two giant cells of two different patients, INI were found only after careful survey of a great number of cells. This finding, coupled with the scarcity of GCT with similar inclusions reported in the literature, reveals the extreme rarity of this finding and leaves open to discussion the specificity of these INI even in Paget's disease, as well as the possible etiological significance in giant cell tumor of bone.

Bone Neoplasms↗
PubMed1984

Effects of acute intoxication with uranyl nitrate on bone formation.

The alteration of bone formation by an acute intoxication with uranyl nitrate is demonstrated by histologic and histometric methods. When compared with the controls, intoxicated animals showed a markedly lower density in healing sockets, while bone formation was reduced in healing sockets as well as in metaphyseal bone.

Animals↗
PubMed1984

Salivary gland tumors induced by 32P.

The oncogenic power of 32P was demonstrated in salivary glands. An intraglandular injection of 0.25 mCi of chromic colloidal phosphate (32P) was administered to young adult Wistar rats. Seven months post-injection, tumors began to appear in the neck region in 64% of the rats. The tumors were sarcomas (50%), carcinomas (35.70%), and carcino-sarcomas (14.28%).

Animals↗
PubMed1983

Radioactive-induced tumors by phosphorus-32 as colloidal compound.

Chromic colloidal phosphate labeled with 32P, which has been proposed for the treatment of several articular diseases, was injected intra-articularly in the knee joint of adult Wistar rats. After a 270 days minimum latent period, tumors began to appear in the injected zone, to a 70% frequency. Ten lung metastases were detected. In five cases, squamous cell carcinomas were induced in the injected area. The relevance of a sound evaluation of the risk involved in treatments with radioactive isotopes, is discussed.

Animals↗
PubMed1983

Percutaneous absorption of uranium compounds.

Percutaneous absorption of soluble and insoluble uranium compounds has been induced in order to obtain information on penetration routes and the tissue injury produced by uranium salts. The high electron density of uranium provided a reliable way to visualize, by electron microscopy, the precise localization of the heavy compounds within the tissues. Few minutes after topical application of uranyl nitrate, dense deposits of uranium were observed at the epidermal barrier level. A few hours later, dense deposits were seen filling the intercellular spaces and were also scattered in the cytoplasm and nucleus. Mortality and body weight measurements indicated the high toxicity of uranyl nitrate and ammonium uranyl tricarbonate; uranyl acetate and ammonium diuranate were less toxic. As no penetration was achieved after uranium dioxide, no variations were detected on these parameters.

Animals↗
PubMed1983

Immunocytochemical detection of carcinoembryonic antigen in salivary gland tumors.

The immunoperoxidase method was applied for carcinoembryonic antigen (CEA) detection in biopsy specimens of salivary gland tumors. 9 out of 10 adenoidcystic carcinomas revealed a strong and abundant reaction in tumoral glands. 10 other specimens of pleomorphic adenomas showed weak staining in the areas of epithelial proliferation. Normal glands adjacent to the tumor mass revealed a weak but constant reaction on the luminal border. As in other types of gland tumor, the quantitative estimation of CEA production by salivary gland tumors may be useful in the monitoring of recurrencies.

Adenoma, Pleomorphic↗