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Biomedical subjects

R L Cook

Publications and source records attributed to R L Cook.

35 records · Page 2Linked to original sources
PubMed1984

Childhood rhabdomyosarcoma xenografts: responses to DNA-interacting agents and agents used in current clinical therapy.

A laboratory model of childhood rhabdomyosarcoma (RMS) has been used to evaluate cytotoxic agents used in current clinical protocols, and DNA-reacting agents that have had either limited or no evaluation in this histiotype. Seven lines of RMS each derived from a different patient were grown as xenografts in immune-deprived mice, six of these being from specimens derived from previously untreated patients. Of the 'conventional' agents, vincristine was the most effective. Of the other agents evaluated [L-phenylalanine mustard (L-PAM), cis-dichlorodiammineplatinum (cis-DDP), mitomycin C and 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC)], L-PAM caused complete regressions in six of seven lines, including those resistant to cyclophosphamide. DTIC had marked activity in five tumors, and mitomycin C in three lines. Cyclophosphamide was active in five tumors, although efficacy was less marked in two lines in comparison to DTIC and mitomycin C.

Animals↗
PubMed1984

Small hospital support of unscheduled overnight air evacuation.

On January 13, 1982, the entire east coast of the United States experienced a severe snowstorm. Blizzard conditions caused closure of civilian airports and Air Force runways. In the midst of the storm, an MAC C-141 aircraft with 48 people on board was inbound from Germany. Diminishing fuel and crew rest requirements made the situation urgent. Loring AFB, ME, had an open runway; and a small 20-bed hospital which accepted the challenge of providing remain-overnight (RON) facilities for the 34 patients and 7 nonmedical attendants from the flight. Within 2 h of arrival, the people from the flight had been fed, were settling for the night, had their records reviewed, were visited by medical staff, and had trebled the inpatient population of the hospital.

Aerospace Medicine↗
PubMed1981

Nursing peer review: a survey of flight nurse section members.

Thirty Flight Nurse Section attendees at the 1980 AsMA meeting participated in a survey regarding nursing peer review. Respondents were middle-to-senior level nurses with a mean age of 39.8 +/- 8.13 years, and mean military grade of Major. While not representative of a broad spectrum of nurses, the responses have great value. Demographic and peer review data are presented, followed by a discussion of findings and recommendations.

Adult↗
PubMed1980

Nursing introspection: peer review.

Nursing peer review is presented as an important quality assurance method which is widely misunderstood and not yet extensively practiced. A survey of nurses working on inhouse units at a USAF medical center was conducted. Of 78 eligible nurses, 60 responded representing each in-house unit. Military grades of 2nd Lt. through Lt. Col. and educational preparations from 2, 3, and 4 year programs provided a heterogeneous sample. Only six respondents had ever participated in peer review and those had been in educational, rather than in practice, settings. The survey results are presented and an effort to initiate nursing peer review in the medical center is described.

Female↗
PubMed1979

Physician-nurse collaboration: a nurse's perspective.

An epidemiologic follow-up study of aircrewmen with asymptomatic exercise-induced ventricular tachycardia was recently conducted by a physician-nurse team at the USAF School of Aerospace Medicine. Using a general systems framework, this paper presents the nurse's perspective of the collaborative effort. Several system elements--such as input, throughout, output, cycles and feedback--are used to analyze the process of physician-nurse interaction during the course of the collaboration.

Aerospace Medicine↗
PubMedDate not supplied

Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora.

The vaginal microflora of healthy asymptomatic women consists of a wide variety (two to five isolates at any one time) of anaerobic and aerobic bacterial genera and species dominated by the facultative, microaerophilic, anaerobic genus Lactobacillus. That the vaginal flora forms part of a dynamically changing ecosystem is evident from the variable prevalence and population levels of each bacterial species detected with repetitive longitudinal sampling, with pregnancy, and with stage in the menstrual cycle. This review emphasizes the role that vaginal lactobacilli may play in control of the vaginal microflora and maintenance of the normal state. Lactobacilli possess many antagonistic properties and produce many metabolites that may be important in maintaining dominance in the vagina. Contradictory data from previous studies regarding the impact of factors such as contraception, catamenial products, and physiologic elements on the vaginal microflora are due in part to poor study design and differences in methodology. Well-designed and controlled investigations with large numbers of individuals in each group are needed, and the limitations of the methodology for such investigations must be considered. Studies of the normal flora, exploring the interaction of lactobacilli and other bacterial species, must be performed before the pathologic processes resulting in vaginitis or systemic sequelae are investigated.

Bacteria↗
PubMedDate not supplied

Abnormal hormone levels in men with coronary artery disease.

Plasma concentrations and urinary excretions of various hormones and hormone metabolites were measured in four groups. Group 1 was composed of 13 men with prior myocardial infarction; Group 2 contained 35 clinically normal men; Group 3 consisted of 44 men with normal coronary arteriograms; and Group 4 was composed of 25 men with severe coronary artery disease shown on arteriogram but no infarction. There were four major findings: Group 1 had significantly higher 24-hour mean plasma concentrations of estrone (E1), dehydroisoandrosterone (DHA), and dehydroisoandrosterone sulfate (DHAS) than Group 2, while Group 3 had the same levels as Group 4; Group 4 had significantly lower urinary excretion of androsterone glucuronide (AG) than Group 3, while Group 1 excreted normal amounts. There are three possible explanations for these findings: 1) myocardial infarction occurring in men with coronary artery disease may elevate the plasma levels of E1, DHA, and DHAS and eliminate the preinfarction depression of urinary AG levels; 2) higher than average levels of E1, DHA, DHAS, and AG may favor the development of infarction in men with coronary artery disease; 3) higher than average levels of E1, DHA, DHAS, and AG may favor survival from any infarction that occurs in men with coronary artery disease. Experimental and epidemiological evidence seems to favor the third possibility.

Adult↗
PubMedDate not supplied

Psychosocial responses to myocardial infarction.

This paper has presented some psychosocial factors believed to contribute to the incidence of coronary artery disease. In addition to the recognized risks, Type A behavior was identified as particularly predisposing to the incidence of CAD. A pattern of psychosocial responses to MI, as a symptomatic manifestation of CAD, was discussed in relation to a specific patient and to the nursing interventions employed. These responses are not peculiar to individuals who suffer an MI, but are common human responses to threat by illness or injury, and as such present a challenge to nurses for appropriate therapeutic intervention.

Anxiety↗