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Biomedical subjects

R L Corio

Publications and source records attributed to R L Corio.

18 recordsLinked to original sources
PubMed1992

Thalidomide for the treatment of chronic graft-versus-host disease.

BACKGROUND: Allogeneic bone marrow transplantation is an accepted therapy for hematologic cancer, aplastic anemia, and inherited immunodeficiencies. Chronic graft-versus-host disease (GVHD) is the principal complication in patients surviving more than 100 days. Thalidomide has been shown experimentally to be effective in treating GVHD. METHODS: We treated 23 patients with chronic GVHD refractory to conventional treatment and 21 patients with "high-risk" chronic GVHD (identified as having at least two of the following three risk factors: chronic GVHD that has evolved from acute GVHD, lichenoid skin or mucous-membrane changes, and hepatic dysfunction. Such patients have a high mortality rate.) with thalidomide in a dose that produced a plasma level of 5 micrograms per milliliter two hours after administration. Therapy was continued for three months after a complete response or for six months after a partial response. RESULTS: The overall actuarial survival of all enrolled patients was 64 percent. Survival was 76 percent among the patients receiving salvage therapy for refractory GVHD and 48 percent among those with high-risk GVHD. A complete response was observed in 14 patients, a partial response in 12 patients, and no response in 18. Side effects were minor, most notably sedation in almost all patients. CONCLUSIONS: In this preliminary trial, thalidomide appeared to be safe and effective for the treatment of chronic GVHD. A trial comparing thalidomide with prednisone in patients with newly diagnosed chronic GVHD will be required to demonstrate its relative efficacy.

Adolescent↗
PubMed1992

Ameloblastoma of the mandible with intracranial metastasis. A case study.

Ameloblastoma is an aggressive locally recurring neoplasm of odontogenic epithelium. We describe a case of a mandibular ameloblastoma with a 17-year history of local recurrences followed by two metachronous intracranial metastases. Central nervous system metastasis without pulmonary involvement is previously unreported in a living patient with ameloblastoma. The behavior of this tumor qualifies it as a malignant ameloblastoma.

Aged↗
PubMed1988

Oncocytic adenocarcinoma of salivary glands.

Oncocytic adenocarcinoma of salivary gland origin is an extremely rare neoplasm. The diagnosis is established on the basis of oncocytic cellular features in conjunction with dysplastic change. These dysplastic changes may occur in benign oncocytomas or arise de novo. The tumor occurs most commonly in the parotid glands of persons over 60 years of age. Tumors that measure less than 2 cm at the initial surgical procedure appear to have a better prognosis than larger tumors. Aggressive surgical intervention at the initial presentation of the neoplasm, compared to simple enucleation, seems to offer a more favorable prognosis. Recurrence is an ominous feature. Metastasis, when it occurs, is widespread.

Adult↗
PubMed1987

Ameloblastic carcinoma: a clinicopathologic study and assessment of eight cases.

The term ameloblastic carcinoma is differentiated from the term malignant ameloblastoma and is defined as an ameloblastoma in which there is histologic evidence of malignancy in the primary tumor or the recurrent tumor (or metastasis), regardless of whether it has metastasized. Eight cases of ameloblastic carcinoma from the Armed Forces Institute of Pathology (AFIP) are reported. The mean age of patients was 30.1 years, with no sex predilection noted. Seven cases involved the mandible and one involved the maxilla, with the posterior regions favored. The most common sign was swelling, although pain, rapid growth, trismus, and dysphonia also occurred. Lesions characteristically were evident as ill-defined destructive radiolucencies, with occasional radiopacities noted. Histologic features generally resembled those of conventional ameloblastoma but with cytologic features of epithelial malignant disease. The clinical course was uniformly aggressive with extensive local destruction and spread, frequent recurrences, and one case of neck node metastasis. The nomenclature and classification of odontogenic carcinomas are discussed, as well as entities that should be included in the differential diagnosis. Further reporting of ameloblastic carcinoma is encouraged.

Adolescent↗
PubMed1987

Histiocytosis X: report of an oral soft tissue lesion without bony involvement.

The case of a 65-year-old white man with painful oral soft tissue granulomatous lesions of histiocytosis X is reported. The clinical course and diagnostic and therapeutic measures are described. The manifestation of symptomatic oral soft lesions with no definable lesions of bone and the age of the patient are not consistent with the usual presentation of this disease, and thus emphasize its clinical variability. The rationale for the therapeutic regimen and the prognosis are reviewed.

Aged↗
PubMed1986

Sarcomas and sarcomatoid neoplasms of the major salivary gland regions. A clinicopathologic and immunohistochemical study of 67 cases and review of the literature.

Sixty-seven cases of sarcomas and sarcomatoid neoplasms of the major salivary gland regions were studied in order to determine the clinical and histomorphologic features and biologic behavior. Fifty-seven of these proved to be sarcomas and the two most common types were malignant schwannoma (11) and fibrosarcoma (9). Nine sarcomas could not be subclassified morphologically. Ten cases, originally believed to be sarcomas, proved by means of immunohistochemistry to be either carcinomas (five cases) or melanomas (five cases). Fifty-nine of the 67 cases occurred in the parotid gland regions, and the remaining eight occurred in the submandibular regions. Twenty of the 67 cases were thought to arise from within the gland, nine from paraglandular tissues, and insufficient data was present to anatomically categorize the other 38 cases. The mean age of occurrence was 42 years for men and 38 years for women. A swelling was the presenting symptom in 64 cases, with a mean duration of 4.3 months. Pain, tenderness, or paralysis were noted in 17 cases, but the swelling was painless in seven cases. Follow-up data of 42 sarcoma patients revealed that 17 experienced recurrences, 16 developed metastases, and 15 died of disease. These rates were lowest among patients with tumors arising from within the gland (Group I) and highest among those patients with tumors of paraglandular origin (Group III). Mean survival time for those dying of disease was 2.4 years, and a 5-year survival time appeared to be a significant indicator of cure. The most successful therapy was either parotidectomy (superficial or total) or a combination of surgery and radiation. The morphologic and the immunohistochemical evidence suggest that the majority of the tumors represent true sarcomas that may arise from undifferentiated pluripotential cells, but that the remainder (15%) represent epithelial malignancies.

Adolescent↗
PubMed1986

Small cell carcinoma of the major salivary glands.

Small cell carcinoma is primarily a pulmonary neoplasm that rarely arises in extrapulmonic sites including salivary glands of the head and neck. Twelve cases of small cell carcinoma of salivary gland origin were retrieved from the Armed Forces Institute of Pathology files. Six tumors occurred in the parotid gland and six in the submandibular gland. Tumors were classified into two categories: those with areas of histologically typical small cell carcinoma (7 cases) and those with areas of typical small cell carcinoma with foci of ductal differentiation (5 cases). Follow-up information was available in all 12 cases. Electron microscopy was done on eight tumors; only one demonstrated round electron dense intracytoplasmic neurosecretory granules. These observations further support evidence in the literature suggesting most of the small cell carcinomas of salivary gland origin are not true neuroendocrine ("oat cell") carcinomas, but actually are small cell ductal carcinomas. These tumors appear to have a better prognosis than small cell carcinoma of the lung or nonsalivary gland sites in the head and neck region, with an estimated 2- and 5-year survival of 70 and 46%, respectively.

Adult↗
PubMed1985

Lingual thyroid.

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Adult↗
PubMed1979

Squamous-cell carcinoma arising in a lateral periodontal cyst.

A rare case of well-differentiated squamous-cell carcinoma arising in the epithelial lining of a lateral periodontal cyst is reported. Submission of surgically removed tissues for histopathologic evaluation is emphasized. The surgical site has been reconstructed and functions well. Because of early diagnosis and treatment, the patient has no evidence of clinical disease 2 1/2 years postoperatively.

Adult↗
PubMed1979

Intraoral rhabdomyomas.

Review of the world literature revealed 16 cases of intraoral rhabdomyomas. Thirteen additional cases of intraoral rhabdomyomas from the files of the Armed Forces Institute of Pathology are reported. The neoplasm occurred principally in adults (mean age 56 years), and the male-female ratio was greater than 2:1. The majority of cases occurred in the floor of the mouth, followed by the soft palate, tongue, and buccal mucosa. Recurrences occurred in four (30 percent) cases, and there was one multiple recurrence. One residual tumor, the result of incomplete surgical removal was noted. Although these tumors have a characteristic microscopic appearance, they were frequently misinterpreted. The size, clinical presentation, and growth pattern of these tumors may reflect their ultimate behavior and prognosis.

Adolescent↗
PubMed1979

Oral pathology.

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Adenocarcinoma↗
PubMed1977

The oral melanotic macule.

A clinical and histologic study of eighty oral melanotic lesions which do not readily fit into recognized categories of melanotic lesions was conducted. These lesions tend to occur in the fifth decade of life and are most frequently seen on the gingiva, with the buccal mucosa and palate the next most frequent sites. The lesions are usually single, smaller than 1 cm., but they may also occur as multiple lesions. There is no sex bias, and there seems to be a number of etiologic factors. In a few cases long-term follow-up was possible. There is no indication of a tendency toward recurrence or development of malignant lesions. Histologically, none of the lesions shows atypia. Melanin pigmentation tends to be present in significant amounts in the basal-cell layer and less often in the lamina propria. There are no outstanding histologic differences among the eighty specimens. It is suggested that the term oral melanotic macule be used for these lesions, unless a specific cause can be confirmed by clinical data. Although these lesions should not be considered premalignant, it would be prudent to remove them for histologic confirmation of clinical impressions.

Adolescent↗
PubMed1976

The labial melanotic macule.

Fifty-five cases of a melanotic lesion of the lips which is well known, but not well described, are reported. The lesions characteristically occur on the lower lips of young adults. Males and females are equally affected. These lesions may be ephelides, postinflammatory melanoses, or unique lesions for which there is no exact cutaneous counterpart. We suggest the term labial melanotic macule as a descriptive one which would encompass the three different constituent entities. On the basis of follow-up information obtained and the histopathologic character of the lesions, this entity is benign and does not, in our opinion, have any malignant potential.

Adolescent↗
PubMed1976

Benign cementoblastoma.

An unusual case of cementoblastoma is presented. It is the second case to be published demonstrating involvement of the pulp, and it is the first instance of a cementoblastoma that appears to have evolved from an impacted tooth. A review of the literature substantiates the fact that this lesion may not be so uncommon as was previously thought, and that pain and facial asymmetry may be significant clinical features.

Adult↗
PubMed1975

Squamous odontogenic tumor. Report of six cases of a previously undescribed lesion.

Six cases of a previously unnamed oral lesion are described and the name squamous odontogenic tumor is applied. The lesion causes radiolucent areas of bone destruction adjacent to the roots of teeth. In one case there were multiple separate lesions. Light microscopy revealed numerous islands of benign squamous epithelium with focal areas of keratinization and calcification. Electron microscope examination in one case showed normal squamous epithelial cells with abundant glycogen granules, tonofilaments and myelin bodies. Complete surgical excision seems the best therapy, as only one lesion recurred following treatment.

Adult↗
PubMedDate not supplied

Delayed eruption associated with an odontoma.

The formation of ghost-like cells complicated the diagnosis of this case. Although treatment should have begun several months earlier, active orthodontic and surgical intervention led to a satisfactory result.

Adolescent↗