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R L Gutberlet

Publications and source records attributed to R L Gutberlet.

9 recordsLinked to original sources
PubMed2001

Generalized frequency coding: a method of preparing polymorphic multistate characters for phylogenetic analysis.

A new method of coding polymorphic multiistate characters for phylogenetic analysis is presented. By dividing such characters into subcharacters, their frequency distributions can be represented with discrete states. Differential weighting is used to counter the effect of representing one character with multiple characters. The new method, generalized frequency coding (GFC), is potentially superior to previously used methods in that it incorporates more information and is applicable to both qualitative and quantitative characters. When applied to a previously published data set that includes both types of polymorphic multistate characters, the method performed well, as assessed with g1 and nonparametric bootstrap statistics and giving results congruent with those of other studies. The data set was also used to compare GFC with both gap-weighting and Manhattan distance step matrix coding. On these grounds and for philosophical reasons, we consider GFC to be a better estimator of phylogeny.

Animals↗
PubMed1986

Neonatal screening with auditory brainstem responses: results of follow-up audiometry and risk factor evaluation.

To determine the incidence and outcome of neurosensory hearing loss in infants, without selection bias, volunteers screened all infants from intensive care and well-baby nurseries of a tertiary care center for risk factors over 1 year; infants with sufficient risk factors were screened for auditory brainstem evoked response. Infants with abnormal findings received audiometric follow-up. Results of a 1-year follow-up study are reported. Risk factor evaluation revealed a 17% incidence of neurosensory hearing loss in a subgroup of infants with multiple risks such as birth weight less than 1500 gm, with perinatal asphyxia, subsequent hypoxemia, and hospital stay greater than 2 months. All infants with permanent hearing loss were assigned to this category. Our results suggest that this population is at greatest risk for early hearing impairment.

Audiometry↗
PubMed1978

Hypermethioninemia in an infant.

We discuss an infant with hepatitis and hypermethioninemia. An inborn error of metabolism, such as methionine adenosyltransferase deficiency or hereditary tyrosinemia, was originally thought to be the basis for these abnormalities. The infant's subsequent clinical course, however, was incompatible with such a diagnosis; the hypermethioninemia was instead due to the trilogy of prematurity, hepatitis, and a high-protein, high-methionine diet.

Amino Acid Metabolism, Inborn Errors↗
PubMed1977

Group B beta-hemolytic streptococcal colonization. Acquisition, persistence, and effect of umbilical cord treatment with triple dye.

Following an outbreak of group B beta-hemolytic streptococcal neonatal infection (GBS), a prevalence survey of GBS colonization was performed on 238 infants. No important differences were noted in the prevalence of colonization when the infants were grouped according to age. Follow-up of 24 colonized babies for three months disclosed that most had persistence of GBS at the rectum and pharynx. Local umbilical cord care with triple dye (TD) or hexachlorophene skin cleanser was compared with untreated controls with respect to rates of GBS colonization. At birth the colonization rates of the three groups were similar. The rate of acquisition of colonization with GBS was 1.0% in the TD group, 6.3% in the hexachlorophene group, and 8.3% in the control group. Triple dye was much more effective than no specific cord care or hexachlorophene in preventing acquisition of GBS colonization.

Acridines↗
PubMed1976

Neonatal pancreatic beta-cell hyperplasia: report of a case with failure of diazoxide and benefit of early subtotal pancreatectomy.

A newborn infant with pancreatic beta-cell hyperplasia had persistent hypoglycemia due to hyperinsulinism. After medical management, including the use of diazoxide and constant glucose infusions had proved ineffective, a subtotal pancreatectomy was curative. Cumulative experience seems to indicate that there should be little delay in performing a subtotal pancreatectomy when aggressive medical management cannot maintain normoglycemia in a neonate.

Diazoxide↗
PubMed1976

Neonatal hypoglycemia revisited, 1975.

Between 1971 and 1973, the frequency of neonatal hypoglycemia was 4.4/1,000 total inborn live births or 15.5/1,000 low-birthweight infants. During that same time, of 257 transferred infants, 13 or 5.1% were hypoglycemic. The hypoglycemic manifestations differed between the inborn and outborn infants as well as from those previously described for transient symptomatic hypoglycemia. This required a new classification for low blood glucose values in the neonate, based on intrauterine nutrition, stress, symptoms, and underlying pathology. Four categories were defined: category I: early transitional hypoglycemia; category II: secondary hypoglycemia; category III: classical transient hypoglycemia; and category IV: recurrent, severe hypoglycemia. One outborn infant was in the latter group due to beta-cell hyperplasia and was only cured after a 90% pancreatectomy. Data revealed that early treatment of perinatal asphyxia was associated with a decreased frequency of hypoglycemia. While not a prospective survey, the evidence suggested that current neonatal intensive care may decrease the frequency of transient symptomatic neonatal hypoglycemia.

Apgar Score↗