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Biomedical subjects

R L Guttu

Publications and source records attributed to R L Guttu.

5 recordsLinked to original sources
PubMed1992

Gigantic osteoma of the mandible: report of a case.

A case of a very large solitary osteoma of the right posterior mandible in a 22-year-old man is presented. The tumor was asymptomatic despite its location and large size. It was removed via an extraoral Risdon approach without complication. The importance of differentiating a large solitary osteoma from a parosteal osteogenic sarcoma is emphasized. Any patient presenting with a solitary osteoma also should be evaluated for Gardner's syndrome.

Adult↗
PubMed1992

Bone formation over partially exposed implants using guided tissue generation.

This pilot study tested whether a semipermeable expanded polytetrafluoroethylene (e-PTFE) membrane could be used to induce new bone to cover the partially exposed surface of titanium and hydroxylapatite (HA)-coated endosseous implants. Twenty threaded titanium and 10 HA-coated implants were placed in the tibia of five mongrel dogs. The implants were placed in a manner that left the cervical 2 to 3 mm exposed. Fifteen implants were used as controls and the rest were covered with an e-PTFE membrane. Animals were killed at 6, 8, and 12 weeks. Those implants covered by the membrane showed a progressive formation of bone on the exposed portion. The threaded titanium control implants showed reactive periosteal bone formation in the adjacent area, but no new bone formation on the exposed threads. The HA-coated controls, however, showed progressive bone formation on the exposed portion. Membrane position appeared to have an effect on the quantity of bone that formed, as those test sites in which there was a collapse of the membrane against the implant showed less new bone than those in which a protected space was created. This study showed that guided tissue generation may be used to induce new bone to form over the exposed portion of an implant, that the amount of new bone is influenced by the width of the space between membrane and implant, and that new bone forms on an exposed HA-coated implant even in the absence of a guiding membrane.

Animals↗
PubMed1990

Delayed healing of muscle after injection of bupivicaine and steroid.

The purpose of this study was to evaluate the histologic changes that occur in an area of rat skeletal muscle injected with a local anesthetic and steroid combination. Thirty adult male laboratory rats were assigned to one of six groups. Group 1 received bupivicaine injected into the right gastrocnemius muscle; Group 2 received procaine; Group 3 received bupivicaine and triamcinolone; Group 4 received procaine and triamcinolone; Group 5 received triamcinolone; and Group 6 received normal saline. Animals were sacrificed at 24 hours and at 1, 2, 3, and 4 weeks. The saline, steroid, and procaine groups showed minimal tissue reaction. The procaine/steroid group had focal areas of inflammation at 24 hours but none on subsequent evaluations. The bupivicaine group showed moderate localized necrosis of muscle fibers and a mild inflammatory cell response at 24 hours. Regeneration of muscle fibers was seen at 1 week, and at 3 weeks the tissue had returned to normal. The bupivicaine/steroid group showed extensive localized necrosis of muscle fibers with a heavy inflammatory cell response at 24 hours. These areas of necrosis persisted throughout the 4-week post-injection period, although some muscle fiber regeneration and fibrosis were also noted. This study shows that bupivicaine produces more tissue reaction than procaine and that the addition of steroid to bupivicaine increases the initial tissue damage and prolongs the healing phase.

Animals↗