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Biomedical subjects

R L Marcus

Publications and source records attributed to R L Marcus.

14 recordsLinked to original sources
PubMed1996

Comparison of anterior cruciate ligament reconstructions using patellar tendon autograft or allograft.

Seventy-eight of 113 consecutive patellar tendon anterior cruciate ligament reconstructions (autograft, 47 of 66; allograft, 31 of 47) were evaluated at an average of 34 months. Reconstructions were compared with Lysholm and Tegner knee-rating scales, physical examination findings, instrumented laxity values, single-leg hop distances, and isokinetic strength results. Lysholm scores > or = 90 were achieved by 69% of autograft patients versus 67% of allograft patients. Desired Tegner activity scores were achieved by 80% of autograft patients versus 74% of allograft patients. Patellofemoral signs and symptoms were absent in 40% of autograft patients versus 44% of allograft patients. Side-to-side laxity differences < or = 3 mm were achieved in 80% of autograft patients versus 70% of allograft patients. Single-leg hop scores > or = 90% of the nonoperated leg were obtained in 76% of autograft patients versus 81% of allograft patients. Isokinetic results between groups were also similar. Traumatic ruptures were sustained by four allograft patients at an average of 11 months postoperatively compared with no traumatic ruptures in the autograft group (P = .011). This was the only difference of statistical significance.

Adult↗
PubMed1996

A study of lung function and chest radiographs in men exposed to zirconium compounds.

Men working with zirconium compounds at one site in the North of England have been monitored since 1975 to evaluate effects on the lung of exposure (mainly < 10 mg/m3) over many years. Chest radiographs (in 1975, 1978, and 1982) and lung function measurements (from 1975-1988) were carried out on all men (178) known to have worked with the compounds and an estimate of cumulative exposure was computed from job title and likely exposures in each era. No evidence was found that zirconium exposure resulted in abnormal chest radiographs or impaired pulmonary function.

Adolescent↗
PubMed1973

Antibody to HSV-2 induced tumor specific antigens in serums from patients with cervical carcinoma.

Antibody distinct from that involved in neutralization and directed to an antigen (AG-4) induced in HEp-2 cells by infection with herpesvirus type 2 was identified in serums from patients with cervical carcinoma by means of a quantitative micro complement fixation test. The presence of antibody to AG-4 correlates well with the extent of the tumor; antibody is virtually absent in matched control women and in women with therapy and without recurrent neoplasia. Reactivity is not observed with control antigen consisting of a cell extract prepared from uninfected HEp-2 cells. The possible prognostic significance of this antibody and its implications are discussed.

Adult↗
PubMed1971

An alternate complement pathway: C-3 cleaving activity, not due to C4,2a, on endotoxic lipopolysaccharide after treatment with guinea pig serum; relation to properdin.

The reaction between endotoxic lipopolysaccharide (LPS) and the guinea pig complement system was shown to proceed by way of an intermediate complex, LPS-X, which contains at least six guinea pig serum proteins. LPS-X, like [unk] (sheep erythrocytes carrying antibody molecules and [unk] complexes), destroys the C3 molecule by cleavage. On incubation at 37 degrees C, LPS-X loses its capacity to destroy C3 at about the same rate as the decay of [unk], so that it has been assumed that LPS-X carries [unk] sites that are responsible for the destruction of C3. We have now shown that monospecific rabbit antiguinea pig C2, which effectively inhibits C3 cleavage by [unk], does not interfere with the destruction of C3 by LPS-X. Furthermore, not more than a trace of C2a(d) is released from LPS-X on incubation at 37 degrees C. These results indicate that LPS-X does not carry a significant quantity of [unk] and, hence, that its capacity to destroy C3 is due to another factor which is presumably a component of the properdin system.

Animals↗
PubMed1971

The occurrence of cryoproteins in synovial fluid; the association of a complement-fixing activity in rheumatoid synovial fluid with cold-precipitable protein.

A significant portion of a complement-fixing activity found in the synovial fluid of patients with rheumatoid arthritis, and previously implicated as a possible cause of the low synovial fluid complement levels in these patients behaves as a high solubility cryoprotein. Analysis of rheumatoid synovial fluid cryoproteins has revealed mixed immunoglobulins, bound complement components, fibrinogen, DNA, and rheumatoid factor. Sorbitol density gradient studies on whole synovial fluid before and after removal of this activity has shown that the complement-fixing activity migrates in the 19S and heavier regions and that portion is removed with cryoprecipitation. Cryoproteins found in nonrheumatoid synovial fluid are generally devoid of complement-fixing activity and predominantly contain fibrinogen. DNA and IgG are also present, with IgG occurring significantly less frequently than in rheumatoid cryoproteins. These findings are discussed in relationship to recent studies demonstrating the presence of complement-fixing antibody to denatured DNA in rheumatoid cryoproteins.

Arthritis, Rheumatoid↗
PubMedDate not supplied

A prospective evaluation of untreated acute grade III acromioclavicular separations.

We prospectively studied the natural history of untreated acute grade III acromioclavicular separations. Twenty-five patients were treated nonoperatively with a sling for comfort through progressive early range of motion as tolerated. Ten additional uninjured subjects underwent strength testing to evaluate the difference between the dominant and nondominant sides so that patient data could be standardized. The patients were examined at intervals of 6, 12, 24, 36, and 52 weeks after injury, at which time they completed a subjective questionnaire and underwent isometric dynamometer testing as well as military press and bench press strength testing. One patient underwent a surgical procedure at 2 weeks after injury because of cosmetic concerns. Twenty of the 25 patients completed the 1-year evaluation and strength-testing protocol. Subjectively, 4 of the 20 patients (20%) thought that their long-term outcome was suboptimal, although for 3 of them it was not enough to warrant surgery. Objective examination and strength testing of the 20 patients revealed no limitation of shoulder motion in the injured extremity and no difference between sides in rotational shoulder muscle strength. The bench press was the only strength test that showed a significant short-term difference, with the injured extremity being an average of 17% weaker. This study documents the natural history of patients with an untreated acute grade III acromioclavicular separation and provides a reference with which to judge all other proposed methods of treatment.

Acromioclavicular Joint↗