PubMed Health⌕ Search

Biomedical subjects

R L Nachman

Publications and source records attributed to R L Nachman.

137 records · Page 8Linked to original sources
PubMed1965

Drug purpura.

Explore the source record for details and available documents.

Drug Hypersensitivity↗
PubMedDate not supplied

Lipoprotein(a) in diet-induced atherosclerosis in nonhuman primates.

Lipoprotein(a) (Lp[a]) is a low density lipoprotein particle that contains plasminogen-like apolipoprotein(a). Recent studies suggest an association of Lp(a) with atherosclerotic vascular disease. We have studied the accumulation of Lp(a) in atherosclerotic arteries of monkeys with diet-induced atherosclerosis. Immunohistochemistry with monospecific Lp(a) antisera revealed striking accumulations of Lp(a) in atherosclerotic coronary artery lesions. There was no Lp(a) in the normal, nonatherosclerotic arteries. Analysis of paired tissue and serum samples from 17 male hyperlipoproteinemic monkeys revealed a significant correlation between aortic wall Lp(a) and serum Lp(a) levels. The serum cholesterol level failed to correlate with either aortic Lp(a) or serum Lp(a). These results add further evidence for the potential role of Lp(a) in the pathogenesis of atherosclerosis.

Animals↗