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Biomedical subjects

R L Prager

Publications and source records attributed to R L Prager.

42 records · Page 3Linked to original sources
PubMed1975

Pharmacoangiographic evaluation of the hemodynamic significance of coronary artery stenoses.

Acute stenoses of varying degree were produced in the circumflex arteries of 5 calves, and chronic stenoses which reduced blood flow by about 50% were effected in the left anterior descending coronary arteries of 14 dogs. Selective vasodilators or amyl nitrite increased blood flow more than 100% in nonstenotic arteries, but less in stenotic ones. Increased transstenotic blood flow was associated with an increased pressure gradient and increased frequency of collateral circulation. Collateral circulation was sometimes recognizable when the pre- and postvasodilatory angiograms were compared but not when the angiograms were examined individually. The altered flow patterns demonstrated by comparative studies may be a very sensitive index of collateral circulation.

Adenosine↗
PubMedDate not supplied

Treatment of patients with neurological deficits associated with cerebral vasospasm by intravascular volume expansion.

Four patients, including one preoperative patient, developed neurological deficits associated with angiographically proven cerebral vasospasm and were treated with intravascular volume expansion. Indicator dilution techniques were employed to monitor intravascular volume and cardiac functions during treatment. All four patients improved promptly. None of the patients developed cardiac or pulmonary dysfunction despite marked increase in intravascular volume and despite several risk factors such as cardiac symptoms, electrocardiographic abnormalities, and advanced age. The techniques of monitoring and controlling intravascular volume are described. We believe that this is an important therapeutic adjunct for certain aneurysm patients.

Adult↗