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R L Rush

Publications and source records attributed to R L Rush.

4 recordsLinked to original sources

Addition of an error correction facility to a functioning data management system.

The National Institute of Neurological and Communicative Disorders and Stroke conducted the Stroke Data Bank, a prospectively collected database, in collaboration with investigators from four clinical centers. A distributed data entry system was originally designed to permit data entry and editing using microcomputers. As data collection progressed, it became evident that the editing system was inadequate. A central data editing component was added to the system, with responsibility for error correction remaining at the clinical centers. This report summarizes the design of the error correction facility and demonstrates the feasibility of its late implementation.

Computer Communication Networks

Creatine phosphokinase in long-term dialysis patients.

Of 90 patients undergoing regular dialysis, 42% had elevated levels of creatine phosphokinase (CPK). The BB isoenzyme was not detected, and only one patient had CPK MB. The elevation of CPK MM level did not correlate with values for calcium, phosphorus, calcium times phosphorus product, dry weight, or parathyroid hormone. Elevated levels of the enzyme correlated directly with muscle weakness in male patients and with hypothyroidism (depressed free thyroxin index) and inversely with treatment with vitamin D, supplements. We conclude that high CPK levels in uremia are secondary to skeletal muscle abnormalities and that hypothyroidism and vitamin D, deficiency may contribute to so-called uremic myopathy.

Adult