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Biomedical subjects

R L Simons

Publications and source records attributed to R L Simons.

At least 37 records · Page 2Linked to original sources
PubMed1980

The office surgical suite: pros and cons.

Today interest and enthusiasm regarding facial plastic surgery is burgeoning. Office surgery provides a new, more expedient, comfortable method of delivery of health care while directly responding to the growing concern among the public and government for improved cost containment of medical services. Awareness of improved surgical techniques and facilities will help to ensure tomorrow's continued growth and satisfaction for both the surgeon and his patient.

Ambulatory Surgical Procedures↗
PubMed1978

Interferon production in children with respiratory syncytial, influenza, and parainfluenza virus infections.

To better understand the recovery process of infants with lower respiratory tract disease due to respiratory syncytial virus, the production of interferon by 129 children (ages 10 days to 24 months) with RSV infection was compared to that of 20 children with influenza (ages 1 to 36 months), and 37 children with parainfluenza virus infection (ages 4 to 66 months). Interferon assays of 285 nasal washes from children with RSV revealed that interferon production occurred in only 5 (4%) of the children. Significantly more children infected with infleunza virus, 55% (P less than 0.001), and parainfluenza virus, 30% (P less than 0.001), produced interferon. In addition, the quantity of interferon produced by children with RSV (geometric mean titer = 2) was significantly less than that of children with influenza (GMT = 26.8, P less than 0.001) and parainfluenza virus (GMT = 23.5, P less than 0.001). In the children infected with RSV, in constrast to those with influenza, interferon detection was not associated with diminished shedding of virus.

Child, Preschool↗
PubMed1977

Effect of selective complement deficiency on the rate of neutralization of enveloped viruses by human sera.

The capacity of human sera genetically deficient in selective complement (C) components to enhance neutralization of enveloped viruses was examined by kinetic plaque reduction assays. Vaccinia virus, a DNA virus, and vesicular stomatitis virus (VSV), an RNA virus, were studied. Exogenous rabbit: or human antibody to vaccinia virus, and guinea pig or human antibody to VSV were provided in limiting, C-dependent concentrations. IgG antibodies predominated in most of the antisera employed. C5-deficient and C6-deficient human sera consistently supported normal rates of neutralization of either virus; this effect was heat-labile. C4-deficient human serum did hot exceed heat-inactivated serum in any neutralization assay. C1r-deficient serum displayed slight heat-labile neutralizing capacity against vaccinia but none against VSV. C2- and C3-deficient sera consistently exhibited measurable but clearly subnormal rates of neutralization. Two fresh agammaglobulinemic sera failed to inactivate either virus in the absence of added antibody. These results confirm and extend earlier evidence, based on neutralization of herpes simplex and Newcastle disease viruses in the presence of early (IgM) antibody and functionally pure guinea pig C components or C-deficient animal sera, that the late-acting components C5-C9 are not required for C-dependent neutralization. Data on four enveloped viruses now agree that this function is mediated by C1-C3, although C1 plus C4 appear to have some neutralizing capacity. This requirement for C1-C3 is overcome, however, in the presence of higher antibody cohcentrations, suggesting that the contribution of the C system to viral neutralization in vivo may be chiefly in the early phase of infection when antibody is limited.

Antibodies, Viral↗
PubMed1975

Chin reduction in profileplasty.

An intraoral method of reduction mentoplasty by subapical horizontal osteotomy of the mandibular symphysis is used in the profileplasty of patients with a protuberant chin who have a normal or functionally satisfactory occlusion. Dental and cephalometric evaluation are necessary to determine if resection of the mandible or orthodontic surgery is necessary for correction of the facial deformity. Because of the tendency toward postoperative osteoneogenesis and fibrosis, overcompensation in the amount of bone removed is important in gaining the maximum aesthetic improvement.

Adult↗
PubMed1975

Evaluation of a topical interferon inducer in experimental influenza infection in volunteers.

The prophylactic and/or therapeutic effect of a low-molecular-weight interferon inducer, CP-20,961, was tested in a double-blind placebo controlled study of experimental influenza A/England/42/72 (H(3)N(2)) infection in normal volunteers. Ten volunteers received CP-20,961 and 10 received placebo. Interferon was detected in nasal secretions of nine of the former and three of the latter group (P < 0.05). Seven in each group became ill, and severity of illness was not different. Also, quantitative virus shedding patterns and antibody response were not different between the two groups. The negative result may have been due to the relatively low quantities of interferon induced.

Administration, Topical↗
PubMed1975

Adjunctive measures in rhinoplasty.

Modern day rhinoplasty demands more than a plan for a new nose. It requires consideration of the individual in terms of a new facial image. Adjacent skeletal and soft tissue weaknesses must be evaluated along with the primary nasal deformity. Frequently facial disharmonies may be corrected with relatively simple operative procedures or with cosmetics. When the procedure does not measurably increase the operative time, postoperative morbidity, or financial cose of the rhinoplasty, it will be more readily accepted by the patient. These criteria are considered in the suggested methods of chin augmentation with alloplastic implants and reduction mentoplasty, utilizing the intraoral subapical horizontal osteotomy of the mandible. At times, simple methods of camouflage will be inadequate. Significant jaw disharmony with unacceptable occlusion requires the interdisciplinary teamwork of the orthodontist, the surgeon, and possibly the prosthodontist. In these cases rhinoplasty waits upon skeletal and dental realignment. Almost without exception, the rhinoplasty patient appreciates and profits from the surgeon's concern over her general appearance. Advice regarding skin care, makeup, hair styling, and facial rejuvenation frequently aids that person in attaining a happy and satisfying rhinoplastic experience.

Beauty Culture↗
PubMedDate not supplied

Nasal tip bossae in rhinoplasty. Etiology, predisposing factors, and management techniques.

OBJECTIVES: To identify preoperative risk factors and surgical techniques that influence the risk of developing postoperative nasal tip bossae in rhinoplasty. A secondary objective was to review the characteristics, management techniques, and outcomes of those study patients with postoperative bossae. DESIGN: Univariate and multivariate analysis carried out in a case series. SETTING: Private facial plastic surgery practice. PATIENTS: All patients who underwent aesthetic nasal surgery that included surgical modification of the nasal tip, and in whom documentation was complete and photographic follow-up was available, were considered eligible. The study group consisted of 875 patients of whom 37 (4.2%) developed bossae postoperatively. MAIN OUTCOME MEASURES: Potential risk factors for postoperative bossae included age, sex, previous nasal surgery, preoperative tip asymmetry, preoperative lobular bifidity, preoperative bossae, skin thickness, surgical tip technique, use of columellar struts, columellar battens, lobular crushed cartilage grafts, and tip shield grafts. RESULTS: In the univariate analysis, females, patients undergoing primary rhinoplasty, younger age groups (12- to 22-year-olds), thin skin, and widened interdomal distance (bifidity) were all noted to have moderate or strong associations with nasal tip bossae. In the multivariate analysis, the younger age group, thin skin, and bifidity were statistically significant and independently associated with nasal tip bossae, independent of the type of tip surgery. In addition, clinically relevant associations were noted in females and patients undergoing primary rhinoplasty. Recognition of risk factors, preventive measures, and treatment methods is recommended.

Adolescent↗
PubMedDate not supplied

Sisters, brothers, and delinquency: evaluating social influence during early and middle adolescence.

Although a number of studies have shown that brothers are highly correlated for delinquent behavior, much less research has been conducted on sisters. We propose that sisters, like brothers, show notable similarity for delinquent behavior, and also promote each other's delinquency through direct interaction. We examined these issues in 164 brother and sister pairs studied over a 4-year period (from early to middle adolescence) in a study of intact families in the rural Midwest. Sibling similarity for self-reports of delinquent behavior were highly correlated for both brothers and sisters. Conditional effects of high levels of hostile-coercive sibling relationships and older sibling delinquency predicted younger sibling delinquency in both brother and sister pairs. For brothers, conditional effects were also detected for high levels of warmth-support, in contrast to sisters. The conditional effects of older sibling delinquency and relationship quality were shown to predict change in younger sibling delinquency through adolescence. The results add to a growing literature on sibling effects as well as theoretical models that emphasize the role of social interaction between siblings as a risk factor for the development of delinquent activity in adolescence.

Adolescent↗
PubMedDate not supplied

The influence of neighborhood disadvantage, collective socialization, and parenting on African American children's affiliation with deviant peers.

This study focused on hypotheses about the contributions of neighborhood disadvantage, collective socialization, and parenting to African American children's affiliation with deviant peers. A total of 867 families living in Georgia and Iowa, each with a 10- to 12-year-old child, participated. Unique contributions to deviant peer affiliation were examined using a hierarchical linear model. Community disadvantage derived from census data had a significant positive effect on deviant peer affiliations. Nurturant/involved parenting and collective socialization processes were inversely associated, and harsh/inconsistent parenting was positively associated, with deviant peer affiliations. The effects of nurturant/involved parenting and collective socialization were most pronounced for children residing in the most disadvantaged neighborhoods.

Adolescent↗
PubMedDate not supplied

Specificity and substitution in the social networks of the elderly.

A set of hypotheses is developed with regard to the way that life cycle, cultural, and structural factors serve to delimit and specify the psychological desires satisfied through interaction with the various categories of others in an elderly person's social network. A second set of hypotheses focuses upon the extent to which the absence of the social category of persons most relevant for the satisfaction of a particular desire can be compensated for by persons from another category. Data are presented which largely support both sets of hypotheses. The findings point to the importance of diversity in the social networks of the aged. Although some substitution of relationships may take place, in the present study no one type of relationship, whether with a spouse, adult children, siblings, confident friends, or organizational acquaintances, was able to satisfy all three of the psychological desires considered.

Adaptation, Psychological↗