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R L Stone

Publications and source records attributed to R L Stone.

28 records · Page 2Linked to original sources
PubMed1987

Evidence for the involvement of endotoxin in toxic shock syndrome.

The toxicity of toxic shock syndrome (TSS) toxin-1 (TSST-1) was evaluated in female, specific pathogen-free rabbits and conventional rabbits. Results after intravenous injections of TSST-1 given to both types of rabbits indicated that specific pathogen-free rabbits were resistant to the lethal effects observed in conventional rabbits. Lethality could be prevented by simultaneous administration of polymyxin B, and analysis of serum before and after dosing confirmed that dosing with TSST-1 resulted in circulating endotoxin. Analysis of sera from humans with TSS showed that endotoxin was present in acute-phase sera but not in convalescent-phase sera. These observations suggest that endogenous endotoxin contributes to rabbit susceptibility to TSST-1 and may play a role in human TSS.

Animals↗
PubMed1977

Absence of eicosatrienoic acid in plasma of sheep parenterally infused with a high glucose fat-free solution.

Five yearling wether sheep were maintained on total intravenous, fat-free feeding for periods in excess of 4 weeks. Analysis of plasma total lipid, neutral lipid, and phospholipid fatty acid patterns showed a decrease in linoleic acid during the first week, after which levels tended to stabilize. Rate of decrease in linoleic acid content of plasma phospholipids of two sheep was different. Changes in nonessential fatty acids were variable. 5,8,11- and 8,11,14-Eicosatrienoic acids were not detected in any of the sheep.

8,11,14-Eicosatrienoic Acid↗
PubMed1970

Inhibition of nucleic acid and protein synthesis mouse spleen cells in vitro by azathioprine.

The effect of azathioprine on macromolecular biosynthesis was studied in mouse spleen cells cultured in vitro. The rate of incorporation of (3)H-thymidine, (3)H-uridine, and (14)C-leucine into acid-insoluble material was used to measure deoxyribonucleic acid, ribonucleic acid, and protein synthesis. Results indicate that azathioprine inhibited nucleic acid and protein synthesis at levels which did not decrease cell viability.

Animals↗