Frictional lichenoid eruption in children. Recurrent pityriasis of the elbows and knees.
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Child↗
Biomedical subjects
R L Sutton
Publications and source records attributed to R L Sutton.
Corticorubral connections: ultrastructural evidence for homotypical synaptic reinnervation after developmental deafferentation.
Corticorubral (CR) connections are reorganized after the red nucleus is deafferented by neonatal hemispherectomy. Our objective was to determine if the new decussating CR axons establish synaptic junctions with their target neurons. The ultrastructure of CR axonal terminal arbors was identified by the anterograde transport and histochemical labeling of wheat germ agglutinin lectin-bound horseradish peroxidase injected unilaterally into the pericruciate neocortex of adult cats that received unilateral neonatal hemispherectomy (HEMI cases) and normal adult cats (control cases). The regional organization of undecussated and decussated CR arbors was nearly equivalent in the HEMI cases. The fine structure of both connections was uniform. Asymmetrical synaptic junctions were observed in frequent axodendritic and infrequent axosomatic boutons en passage and boutons terminaux. The undecussated arbors formed the principal connection in the control cases. However, the fine structures of the decussated and undecussated arbors were comparable and matched the arrangements in the HEMI cases. We conclude that developmental deafferentation redirects CR axons to provide stable synaptic afferents to new targets. The reinnervation is homotypical in terms of regional and fine structure organization. It is likely to be an important factor in chemically mediated neurotransmission that contributes to the sparing/recovery of function after brain damage.
Animals↗
Effects of fetal forebrain transplants in ibotenic-injured nucleus basalis: an anatomical investigation.
Survival of fetal basal forebrain transplant (TP) into ibotenic-injured nucleus basalis of rats was examined after a delay lesion and TP (1 or 2 weeks) and a delay between harvest and TP (1-4.5 hours). Optimal TP survival occurred for TP made 2 weeks postlesion and less than 2 hours after harvesting. In these cases large, healthy TP-neurons displayed robust cytochrome oxidase (CO) activity and sent cholinergic processes throughout the TP and occasionally into host tissue. A mild astrocytic reaction was observed within the TP and at the host-TP interface. Surviving TPs increased choline acetyltransferase innervation and CO activity within the ipsilateral frontoparietal cortex. Therefore data suggest that fetal cholinergic TPs into the damaged NBM reduced neuronal degeneration within the NBM and stimulated remaining neurons spared by the lesion.
Acetylcholinesterase↗
The effect of seizures on recovery of function following cortical contusion in the rat.
The effect of seizures on recovery of motor function was studied in rats following unilateral contusion of the sensorimotor cortex. Animals receiving two electroconvulsive seizures (ECSs) within the first 24 hours postcontusion showed accelerated recovery of beam-walking ability, reduced volume of necrosis and less spontaneous activity compared to animals receiving only contusions. Animals receiving seven ECSs after contusion had an even smaller volume of necrosis and also reduced spontaneous activity compared to the two ECS group and to controls receiving contusions alone. However, for recovery of beam-walking ability, the seven ECS group did not differ from control rats receiving only contusions. The results are discussed in terms of the effects of seizures on catcholamines, gamma-amino butyric acid, cerebral blood flow and possible effects on remote functional depression after brain injury.
Animals↗