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Biomedical subjects

R L Zuehlke

Publications and source records attributed to R L Zuehlke.

At least 19 recordsLinked to original sources

Pachyonychia congenita: surgical management of the nail changes.

The fingernails of a woman with pachyonychia congenita were ablated by several different methods. The most effective, most rapidly performed, and most acceptable method was vigorous curettage and electrofulguration of the matrices and beds of the nails. The responses to treatment suggest that the matrix, rather than the bed, is the site from which the abnormality of the nails develops in pachyonychia congenita. Removal of the nail beds is not necessary to prevent recurrence of deformed nails, but it may reduce hyperkeratosis in their sites.

Adult↗

Pressure-potential alopecia areata.

In order to create awareness of a potential adverse effect of extraoral orthodontic appliances, we report the development of alopecia areata in two patients. Both patients experienced the onset of alopecia areata directly under sites of pressure from thier "headgear." In one patient the hair loss began 2 weeks after she began using her appliance. The other girl noticed patchy alopecia 2 to 3 weeks following an increase in the pressure and duration of use of an extraoral appliance. One of the patients also developed other areas of alopecia areata in sites unrelated to pressure. In both cases relief of the pressure was accompanied by regrowth of hair in about 5 months. One of the patients received corticosteroid injections into the patches of alopecia areata; the other had no medical therapy. We conclude that alopecia areata can be made manifest by local pressure, such as that from orthodontic appliances.

Adolescent↗

Solitary actinic porokeratosis.

An 83-year-old man experienced abrupt onset of a solitary lesion of porokeratosis on his bald, actinically damaged scalp. The features in this case are unusual and represent another point in the broad spectrum of lesions characterized by the cornoid lamella of porokeratosis.

Aged↗

Cutaneous metastatic carcinoma and elephantiasis symptomatica.

An elderly man had elephantiasis of a lower extremity that was partially covered with verrucose papules, but also had sharply delineated islands of normal-appearing skin. Biopsy showed cutaneous metastases to be responsible, at least in part, for the clinical appearance. Patients with elephantiasis with "skipped areas" should be suspected of having cutaneous metastatic malignant neoplasms.

Adenocarcinoma↗

Nodular grouped milia.

A young girl had a distinctive nodule with white spherules. Histologically, the lesion was composed of multiple small keratotic cysts.

Cysts↗

Antimalarial therapy for lupus erythematosus: an apparent advantage of quinacrine.

A retrospective study of 26 quinacrine-treated lupus erythematosus patients failed to show evidence of drug-induced ocular changes. Although quinacrine commonly produces minor side effects, such as yellow discoloration of the skin, and may rarely produce very serious side effects, such as aplastic anemia, it appears to produce much less oculotoxicity than does chloroquine.

Aged↗